WASF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WASF2_MOUSE
• UniProt AC: Q8BH43
• Protein Name: Wiskott-Aldrich syndrome protein family member 2
• Gene Name: Wasf2 {ECO:0000312|MGI:MGI:1098641}
• Organism: Mus musculus (Mouse).
• Sequence Length: 497
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. At the interface between the lamellipodial actin meshwork and the membrane..
• Protein Description: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity)..
• Protein Sequence: MPLVTRNIEPRHLCRQTLPSDTSELECRTNITLANVIRQLGSLSKYAEDIFGEICTQASAFASRVNSLAERVDRVQVKVTQLDPKEEEVSLQGINTRKAFRSSTTQDQKLFDRNSLPVPVLETYNSCDAPPPLNNLSPYRDDGKEALKFYTNPSYFFDLWKEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKERLGPSGYSSTLVYQNGSIGSVENVDAASYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPADNQRGSVLAGPKRTSMVSPSHPPPAPPLSSPPGPKPGFAPPPAPPPPPPMSVPPPLPSMGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPMPPPPLSQPSGGAPPPPPPPPPPGPPPLPFSGADGQPAAPPPPPPSEATKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	PRHLCRQTLPSDTSE HHHHHCCCCCCCCCC	22.68	30635358
20	Phosphorylation	LCRQTLPSDTSELEC HHCCCCCCCCCCHHH	57.54	30635358
22	Phosphorylation	RQTLPSDTSELECRT CCCCCCCCCCHHHHC	28.56	30635358
23	Phosphorylation	QTLPSDTSELECRTN CCCCCCCCCHHHHCC	45.21	30635358
29	Phosphorylation	TSELECRTNITLANV CCCHHHHCCHHHHHH	42.50	22817900
32	Phosphorylation	LECRTNITLANVIRQ HHHHCCHHHHHHHHH	23.14	22817900
85	Ubiquitination	KVTQLDPKEEEVSLQ EEEECCCCCCEECCC	76.93	-
90	Phosphorylation	DPKEEEVSLQGINTR CCCCCEECCCCCCHH	20.46	29472430
96	Phosphorylation	VSLQGINTRKAFRSS ECCCCCCHHHHHHCC	31.46	-
102	Phosphorylation	NTRKAFRSSTTQDQK CHHHHHHCCCCHHHH	26.11	25338131
103	Phosphorylation	TRKAFRSSTTQDQKL HHHHHHCCCCHHHHC	31.08	26824392
126	Phosphorylation	PVLETYNSCDAPPPL CEEECCCCCCCCCCC	11.71	26643407
137	Phosphorylation	PPPLNNLSPYRDDGK CCCCCCCCCCCCCCH	23.24	26745281
139	Phosphorylation	PLNNLSPYRDDGKEA CCCCCCCCCCCCHHH	24.25	26643407
150	Phosphorylation	GKEALKFYTNPSYFF CHHHHHHHCCHHHHH	12.20	22817900
155	Phosphorylation	KFYTNPSYFFDLWKE HHHCCHHHHHHHHHH	14.99	-
161	Ubiquitination	SYFFDLWKEKMLQDT HHHHHHHHHHHHHHH	55.54	-
215	Phosphorylation	MGQEFVESKERLGPS HHHHHHHHHHHHCCC	34.22	29472430
216	Ubiquitination	GQEFVESKERLGPSG HHHHHHHHHHHCCCC	33.09	27667366
284	Phosphorylation	PADNQRGSVLAGPKR CCCCCCCCEEECCCC	19.02	28833060
292	Phosphorylation	VLAGPKRTSMVSPSH EEECCCCCCCCCCCC	27.57	26643407
293	Phosphorylation	LAGPKRTSMVSPSHP EECCCCCCCCCCCCC	22.63	25266776
296	Phosphorylation	PKRTSMVSPSHPPPA CCCCCCCCCCCCCCC	16.43	29233185
298	Phosphorylation	RTSMVSPSHPPPAPP CCCCCCCCCCCCCCC	40.91	26643407
307	Phosphorylation	PPPAPPLSSPPGPKP CCCCCCCCCCCCCCC	46.72	25266776
308	Phosphorylation	PPAPPLSSPPGPKPG CCCCCCCCCCCCCCC	42.68	25266776
428	Phosphorylation	EATKPKSSLPAVSDA CCCCCCCCCCCCHHH	44.49	28833060
441	Phosphorylation	DARSDLLSAIRQGFQ HHHHHHHHHHHHHHH	29.01	29514104
470	Phosphorylation	VVGNDVATILSRRIA CCCHHHHHHHHCEEE	23.46	28066266
473	Phosphorylation	NDVATILSRRIAVEY HHHHHHHHCEEEEEC	18.70	25266776
481	Phosphorylation	RRIAVEYSDSEDDSS CEEEEECCCCCCCCC	22.58	22817900
483	Phosphorylation	IAVEYSDSEDDSSEF EEEECCCCCCCCCCC	36.66	22817900
487	Phosphorylation	YSDSEDDSSEFDEDD CCCCCCCCCCCCCCC	44.05	22817900
488	Phosphorylation	SDSEDDSSEFDEDDW CCCCCCCCCCCCCCC	49.64	22817900
496	Phosphorylation	EFDEDDWSD------ CCCCCCCCC------	40.20	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
96	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
137	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
150	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
150	Y	Phosphorylation	Kinase	ABL	P00520	PSP
470	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WASF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WASF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WASF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.