NCAN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCAN_MOUSE
• UniProt AC: P55066
• Protein Name: Neurocan core protein
• Gene Name: Ncan
• Organism: Mus musculus (Mouse).
• Sequence Length: 1268
• Subcellular Localization: Secreted.
• Protein Description: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid..
• Protein Sequence: MGAGSVWASGLLLLWLLLLVAGDQDTQDTTATEKGLRMLKSGSGPVRAALAELVALPCFFTLQPRLSSLRDIPRIKWTKVQTASGQRQDLPILVAKDNVVRVAKGWQGRVSLPAYPRHRANATLLLGPLRASDSGLYRCQVVKGIEDEQDLVTLEVTGVVFHYRAARDRYALTFAEAQEACRLSSATIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRDPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCQRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPAPGARFDAYCFRAHHHTAQHGDSEIPSSGDEGEIVSAEGPPGRELKPSLGEQEVIAPDFQEPLMSSGEGEPPDLTWTQAPEETLGSTPGGPTLASWPSSEKWLFTGAPSSMGVSSPSDMGVDMEATTPLGTQVAPTPTMRRGRFKGLNGRHFQQQGPEDQLPEVAEPSAQPPTLGATANHMRPSAATEASESDQSHSPWAILTNEVDEPGAGSLGSRSLPESLMWSPSLISPSVPSTESTPSPKPGAAEAPSVKSAIPHLPRLPSEPPAPSPGPSEALSAVSLQASSADGSPDFPIVAMLRAPKLWLLPRSTLVPNMTPVPLSPASPLPSWVPEEQAVRPVSLGAEDLETPFQTTIAAPVEASHRSPDADSIEIEGTSSMRATKHPISGPWASLDSSNVTMNPVPSDAGILGTESGVLDLPGSPTSGGQATVEKVLATWLPLPGQGLDPGSQSTPMEAHGVAVSMEPTVALEGGATEGPMEATREVVPSTADATWESESRSAISSTHIAVTMARAQGMPTLTSTSSEGHPEPKGQMVAQESLEPLNTLPSHPWSSLVVPMDEVASVSSGEPTGLWDIPSTLIPVSLGLDESVLNVVAESPSVEGFWEEVASGQEDPTDPCENNPCLHGGTCHTNGTVYGCSCDQGYAGENCEIDIDDCLCSPCENGGTCIDEVNGFICLCLPSYGGSLCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAERDCRRRAGHLTSVHSPEEHKFINSFGHENSWIGLNDRTVERDFQWTDNTGLQYENWREKQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLVGVRKIKYNVHATVRYQCDEGFSQHRVATIRCRNNGKWDRPQIMCIKPRRSHRMRRHHHHPHRHHKPRKEHRKHKRHPAEDWEKDEGDFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	FTLQPRLSSLRDIPR HHCCCCHHCCCCCCC	28.71	28725479
68	Phosphorylation	TLQPRLSSLRDIPRI HCCCCHHCCCCCCCC	31.83	28725479
121	N-linked_Glycosylation	AYPRHRANATLLLGP CCCCCCCCCEEEECC	33.15	-
335	Phosphorylation	APGVRTVYRFANRTG CCCCHHHHHHHCCCC	10.21	23335269
339	N-linked_Glycosylation	RTVYRFANRTGFPAP HHHHHHHCCCCCCCC	39.06	-
742	N-linked_Glycosylation	WASLDSSNVTMNPVP CCCCCCCCCCCCCCC	36.91	-
978	N-linked_Glycosylation	HGGTCHTNGTVYGCS CCCEECCCCEEEECC	22.07	-
1175	N-linked_Glycosylation	GPPPAVENASLVGVR CCCCCCCCCEEEEEE	28.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCAN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCAN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCAN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NCAN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.