ABR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABR_MOUSE
• UniProt AC: Q5SSL4
• Protein Name: Active breakpoint cluster region-related protein
• Gene Name: Abr
• Organism: Mus musculus (Mouse).
• Sequence Length: 859
• Protein Description: GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them (By similarity)..
• Protein Sequence: MEPLSHRGLPRLSWIDTLYSNFSYGAEDYDAEGHEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDSVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKTKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33 (in isoform 4)	Phosphorylation	-	34.92	26824392
44	Phosphorylation	QKGPPEGSETMPYID CCCCCCCCCCCCCCC	28.38	24925903
46	Phosphorylation	GPPEGSETMPYIDES CCCCCCCCCCCCCCC	25.74	24925903
49	Phosphorylation	EGSETMPYIDESPTM CCCCCCCCCCCCCCC	15.35	24925903
53	Phosphorylation	TMPYIDESPTMSPQL CCCCCCCCCCCCCCH	23.17	25521595
55	Phosphorylation	PYIDESPTMSPQLSA CCCCCCCCCCCCHHC	39.29	25521595
57	Phosphorylation	IDESPTMSPQLSARS CCCCCCCCCCHHCCC	16.39	25521595
61	Phosphorylation	PTMSPQLSARSQGGG CCCCCCHHCCCCCCC	19.18	24925903
64	Phosphorylation	SPQLSARSQGGGDSV CCCHHCCCCCCCCCC	32.66	27087446
70	Phosphorylation	RSQGGGDSVSPTPPE CCCCCCCCCCCCCCC	27.98	25521595
72	Phosphorylation	QGGGDSVSPTPPEGL CCCCCCCCCCCCCCC	27.32	25521595
74	Phosphorylation	GGDSVSPTPPEGLAP CCCCCCCCCCCCCCC	43.92	25521595
84	Phosphorylation	EGLAPGVEAGKGLEM CCCCCCCCCCCCHHH	58.58	24719451
123	Phosphorylation	PMKPLKATATTSQPV CCCCCCCCCCCCCCE	23.97	29899451
127	Phosphorylation	LKATATTSQPVLTIQ CCCCCCCCCCEEEHH	28.29	29899451
147	Phosphorylation	FYKIQDIYEIHKEFY HHHHHHHHHHHHHHH	19.68	51457571
192	Ubiquitination	KAFVDNYKVALETAE HHHHCHHHHHHHHHH	27.56	22790023
192 (in isoform 2)	Ubiquitination	-	27.56	22790023
204 (in isoform 2)	Ubiquitination	-	22.81	-
293	Phosphorylation	DPRRTAVTTPKGETR CCCCCEECCCCCCHH	34.61	29899451
294	Phosphorylation	PRRTAVTTPKGETRQ CCCCEECCCCCCHHH	19.19	29899451
305	Phosphorylation	ETRQLVKDGFLVEMS CHHHHHCCCEEEEEC	45.67	24719451
306	Phosphorylation	TRQLVKDGFLVEMSE HHHHHCCCEEEEECH	16.45	24719451
385	Phosphorylation	EDMKTKISALKSEIQ HHHHHHHHHHHHHHH	29.16	24759943
389	Phosphorylation	TKISALKSEIQKEKA HHHHHHHHHHHHHHC	40.56	25338131
632	Phosphorylation	KFTSRDMSLKRTPSK EEECCCCCCCCCCCC	34.72	25159016
636	Phosphorylation	RDMSLKRTPSKKQTG CCCCCCCCCCCCCCC	30.26	72271853
638	Phosphorylation	MSLKRTPSKKQTGVF CCCCCCCCCCCCCCC	52.45	46157285
642	Phosphorylation	RTPSKKQTGVFGVKI CCCCCCCCCCCCEEE	44.16	25338131
644	Phosphorylation	PSKKQTGVFGVKISV CCCCCCCCCCEEEEE	4.24	24719451
648	Phosphorylation	QTGVFGVKISVVTKR CCCCCCEEEEEEECC	29.64	24719451
654	Phosphorylation	VKISVVTKRERSKVP EEEEEEECCHHCCCC	40.42	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAC1_MOUSE	Rac1	physical	17116687

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.