KCAB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCAB1_MOUSE
• UniProt AC: P63143
• Protein Name: Voltage-gated potassium channel subunit beta-1
• Gene Name: Kcnab1
• Organism: Mus musculus (Mouse).
• Sequence Length: 401
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel al
• Protein Description: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. [PubMed: 10454353 Modulates action potentials via its effect on the pore-forming alpha subunits]
• Protein Sequence: MQVSIACTEHNLKSRNGEDRLLSKQSSNAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	GEDRLLSKQSSNAPN HHHHHHCCCCCCCCC	54.92	22790023
26	Phosphorylation	DRLLSKQSSNAPNVV HHHHCCCCCCCCCHH	29.33	29899451
27	Phosphorylation	RLLSKQSSNAPNVVN HHHCCCCCCCCCHHH	34.22	29899451
60	Phosphorylation	FTPQHHISLKESTAK CCCCCCEECCHHHHH	29.09	29899451
64	Phosphorylation	HHISLKESTAKQTGM CCEECCHHHHHHHCC	31.88	-
69	Phosphorylation	KESTAKQTGMKYRNL CHHHHHHHCCCCHHC	38.24	-
90	Phosphorylation	VSCLGLGTWVTFGGQ EEEECCCCEEEECCC	23.08	-
93	Phosphorylation	LGLGTWVTFGGQISD ECCCCEEEECCCCCH	14.23	-
108	Phosphorylation	EVAERLMTIAYESGV HHHHHHHHHHHHHCC	13.67	25168779
111	Phosphorylation	ERLMTIAYESGVNLF HHHHHHHHHHCCCCC	13.53	25168779
113	Phosphorylation	LMTIAYESGVNLFDT HHHHHHHHCCCCCCH	35.05	25168779
120	Phosphorylation	SGVNLFDTAEVYAAG HCCCCCCHHHHHHCC	19.86	25168779
124	Phosphorylation	LFDTAEVYAAGKAEV CCCHHHHHHCCCCEE	5.13	25168779
145	Phosphorylation	KKKGWRRSSLVITTK HHCCCCCCEEEEEEE	21.32	28833060
146	Phosphorylation	KKGWRRSSLVITTKL HCCCCCCEEEEEEEE	25.50	22942356
158	Ubiquitination	TKLYWGGKAETERGL EEEECCCCCCCCCCC	38.83	22790023
302	Ubiquitination	ESSRASLKCYQWLKE HHHHHHHHHHHHHHH	28.53	22790023
324	Ubiquitination	RKQQNKLKDLSPIAE HHHHHHHHCCHHHHH	59.23	22790023
395	Phosphorylation	ILRNKPYSKKDYRS- HHHCCCCCHHHCCC-	41.58	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCAB1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCAB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCAB1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KCAB1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.