GRIK5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRIK5_MOUSE
• UniProt AC: Q61626
• Protein Name: Glutamate receptor ionotropic, kainate 5
• Gene Name: Grik5
• Organism: Mus musculus (Mouse).
• Sequence Length: 979
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA..
• Protein Sequence: MPAELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGTPAEATSPPRPRPGPTGPRELTEHE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	IVAFANPSCQVLSSL HHHHHCCHHHHHHHH	19.59	29514104
22	Phosphorylation	NPSCQVLSSLRMAAI CCHHHHHHHHHHHHH	28.59	29514104
23	Phosphorylation	PSCQVLSSLRMAAIL CHHHHHHHHHHHHHC	18.81	29514104
155	Phosphorylation	AVSRILKSFNYPSAS HHHHHHHHCCCCCHH	18.45	24719451
162	Phosphorylation	SFNYPSASLICAKAE HCCCCCHHHHHHHHH	23.70	24719451
219	N-linked_Glycosylation	STIIIDANASISHLV CEEEEECCCCHHHHH	30.39	-
271	N-linked_Glycosylation	ILGFSMFNTSHPFYP CCCEECCCCCCCCCH	31.84	-
285	N-linked_Glycosylation	PEFVRSLNMSWRENC HHHHHHCCCHHHHCC	24.56	-
316	Phosphorylation	DAVHVVVSAVRELNR HHHHHHHHHHHHHCC	14.94	-
322	N-linked_Glycosylation	VSAVRELNRSQEIGV HHHHHHHCCCCCCCC	36.48	-
372	N-linked_Glycosylation	NSKGQRTNYTLRILE CCCCCCCEEEEEEHH	29.95	-
394	N-linked_Glycosylation	EIGVWYSNRTLAMNA EEEEEECCCEEEECC	25.84	-
400	N-linked_Glycosylation	SNRTLAMNATTLDIN CCCEEEECCEEECEE	28.64	-
407	N-linked_Glycosylation	NATTLDINLSQTLAN CCEEECEEHHHHHCC	33.05	-
414	N-linked_Glycosylation	NLSQTLANKTLVVTT EHHHHHCCCEEEEEE	40.74	-
478	N-linked_Glycosylation	LYGAPEPNGSWTGMV CCCCCCCCCCCCHHH	56.31	-
501	Phosphorylation	DLAVAAFTITAEREK CEEEEEEEEEECHHH	16.82	28285833
503	Phosphorylation	AVAAFTITAEREKVI EEEEEEEEECHHHHC	21.29	28285833
705	Phosphorylation	PSVFVKSTEEGIARV CCEEEECCHHHHHHH	32.13	28059163
735	N-linked_Glycosylation	YHRRLNCNLTQIGGL HHHHHCCCCCCCCCC	45.08	-
842	S-palmitoylation	ESEEVSVCQEMLQEL CCHHHHHHHHHHHHH	1.90	28680068
876	Phosphorylation	GPSRALLSLRAVREM CHHHHHHHHHHHHHH	19.36	24719451
891	Phosphorylation	RLSNGKLYSAGAGGD HHHCCCEEECCCCCC	10.44	-
960	Phosphorylation	LGTPAEATSPPRPRP CCCCCCCCCCCCCCC	33.02	29899451
961	Phosphorylation	GTPAEATSPPRPRPG CCCCCCCCCCCCCCC	39.70	29899451
970	Phosphorylation	PRPRPGPTGPRELTE CCCCCCCCCCCCCCC	66.78	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRIK5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRIK5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRIK5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GRIK5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.