DCAF7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCAF7_MOUSE
• UniProt AC: P61963
• Protein Name: DDB1- and CUL4-associated factor 7
• Gene Name: Dcaf7
• Organism: Mus musculus (Mouse).
• Sequence Length: 342
• Subcellular Localization: Cytoplasm . Nucleus. Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
• Protein Description: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity)..
• Protein Sequence: MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVQLVGLDEESSEFICRNTFDHPYPTTKLMWIPDTKGVYPDLLATSGDYLRVWRVGETETRLECLLNNNKNSDFCAPLTSFDWNEVDPYLLGTSSIDTTCTIWGLETGQVLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYNNCLEILRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	KRKEIYKYEAPWTVY CCCEEEEEECCEEEE	10.60	-
18	Phosphorylation	YKYEAPWTVYAMNWS EEEECCEEEEEECEE	11.54	-
20	Phosphorylation	YEAPWTVYAMNWSVR EECCEEEEEECEECC	7.86	-
38	Phosphorylation	RFRLALGSFVEEYNN HHHHHHHHHHHHHCC	27.28	25338131
81	Ubiquitination	LMWIPDTKGVYPDLL EEECCCCCCCCHHHE	54.48	-
194	Phosphorylation	GGRDMFASVGADGSV CCCCCEEEECCCCCE	15.15	-
256	Glutathionylation	ILDVRVPCTPVARLN EEEEECCCCCCHHHC	6.50	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCAF7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCAF7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCAF7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DCAF7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.