THY1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THY1_MOUSE
• UniProt AC: P01831
• Protein Name: Thy-1 membrane glycoprotein
• Gene Name: Thy1
• Organism: Mus musculus (Mouse).
• Sequence Length: 162
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain..
• Protein Sequence: MNPAISVALLLSVLQVSRGQKVTSLTACLVNQNLRLDCRHENNTKDNSIQHEFSLTREKRKHVLSGTLGIPEHTYRSRVTLSNQPYIKVLTLANFTTKDEGDYFCELQVSGANPMSSNKSISVYRDKLVKCGGISLLVQNTSWMLLLLLSLSLLQALDFISL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Pyrrolidone_carboxylic_acid	VLQVSRGQKVTSLTA HHHHCCCCCEEEEEE	35.62	6177036
20	Pyrrolidone_carboxylic_acid	VLQVSRGQKVTSLTA HHHHCCCCCEEEEEE	35.62	6177036
20	Pyrrolidone_carboxylic_acid	VLQVSRGQKVTSLTA HHHHCCCCCEEEEEE	35.62	-
23	Phosphorylation	VSRGQKVTSLTACLV HCCCCCEEEEEEEHH	25.67	29899451
24	Phosphorylation	SRGQKVTSLTACLVN CCCCCEEEEEEEHHC	27.06	25521595
28	S-nitrosylation	KVTSLTACLVNQNLR CEEEEEEEHHCCCCC	3.52	22588120
42	N-linked_Glycosylation	RLDCRHENNTKDNSI CCEEECCCCCCCCCC	56.18	6177036
48	Phosphorylation	ENNTKDNSIQHEFSL CCCCCCCCCEEEEEC	33.49	29899451
74	Phosphorylation	TLGIPEHTYRSRVTL CCCCCCCCCCCEEEE	20.97	29899451
77	Phosphorylation	IPEHTYRSRVTLSNQ CCCCCCCCEEEECCC	22.23	29899451
82	Phosphorylation	YRSRVTLSNQPYIKV CCCEEEECCCCEEEE	24.85	22817900
86	Phosphorylation	VTLSNQPYIKVLTLA EEECCCCEEEEEEEC	12.01	29899451
94	N-linked_Glycosylation	IKVLTLANFTTKDEG EEEEEECCCCCCCCC	37.60	6177036
103	Phosphorylation	TTKDEGDYFCELQVS CCCCCCCEEEEEEEE	22.45	28576409
118	N-linked_Glycosylation	GANPMSSNKSISVYR CCCCCCCCCCEEEEH	34.48	6177036
122	Phosphorylation	MSSNKSISVYRDKLV CCCCCCEEEEHHHCE	21.86	29899451
124	Phosphorylation	SNKSISVYRDKLVKC CCCCEEEEHHHCEEC	13.30	29899451
131	GPI-anchor amidated cysteine	YRDKLVKCGGISLLV EHHHCEECCCCEEEE	4.74	-
131	GPI-anchor	YRDKLVKCGGISLLV EHHHCEECCCCEEEE	4.74	6177036

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THY1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THY1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THY1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of THY1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

GPI-anchor

"Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin.";
Williams A.F., Gagnon J.;
Science 216:696-703(1982).
Cited for: PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, ANDGPI-ANCHOR AT CYS-131.
PubMed: 6177036

N-linked Glycosylation

"Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin.";
Williams A.F., Gagnon J.;
Science 216:696-703(1982).
Cited for: PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, ANDGPI-ANCHOR AT CYS-131.
PubMed: 6177036

Pyrrolidone carboxylic acid

"Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin.";
Williams A.F., Gagnon J.;
Science 216:696-703(1982).
Cited for: PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, ANDGPI-ANCHOR AT CYS-131.
PubMed: 6177036