NMDE3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMDE3_MOUSE
• UniProt AC: Q01098
• Protein Name: Glutamate receptor ionotropic, NMDA 2C
• Gene Name: Grin2c
• Organism: Mus musculus (Mouse).
• Sequence Length: 1239
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). [PubMed: 1377365 Sensitivity to glutamate and channel kinetics depend on the subunit composition]
• Protein Sequence: MGGALGPALLLTSLLGAWAGLGAGQGEQAVTVAVVFGSSGPLQAQARTRLTPQNFLDLPLEIQPLTIGVNNTNPSSILTQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKSGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICHNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLTAGSAQANVLKMLQAARDMVSTADVSGSLDRATRTIENWGNNRRAPAPTTSGPRSCTPGPPGQPSPSGWRPPGGGRTPLARRAPQPPARPATCAGSPQPDVSRASCRHAWDARWPVRVGHQGSHLSASERRALPERSLLHAHCHYSSFPRAERSGRPFLPLFPEPPEPDDLPLLGPEQLARREALLRAAWARGPRPRHASLPSSVAEAFTRSNPLPARCTGHACACPCPQSRPSCRHVAQTQSLRLPSYREACVEGVPAGVAATWQPRQHVCLHTHTHLPFCWGTVCRHPPPCSSHSPWLIGTWEPPSHRGRTLGLGTGYRDSGVLEEVSREACGTQGFPRSCTWRRISSLESEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	N-linked_Glycosylation	QPLTIGVNNTNPSSI EEEEEECCCCCHHHH	44.38	-
73	N-linked_Glycosylation	TIGVNNTNPSSILTQ EEECCCCCHHHHHHH	36.26	-
212	Phosphorylation	PGGPRARTQRLLRQV CCCHHHHHHHHHHHC	19.63	30635358
227	Phosphorylation	DAPVLVAYCSREEAE CCCEEEEECCHHHHH	5.40	30635358
229	Phosphorylation	PVLVAYCSREEAEVL CEEEEECCHHHHHHH	30.01	30635358
284	Phosphorylation	VTESWRLSLRQKVRD ECHHHHHHHHHHHHH	16.97	24704852
337	N-linked_Glycosylation	AFYRHLLNVTWEGRD HHHHHHHCCEECCCC	35.22	-
438	N-linked_Glycosylation	VPCRRQSNHTFSSGD CCCCCCCCCCCCCCC	29.85	-
440	Phosphorylation	CRRQSNHTFSSGDIT CCCCCCCCCCCCCCC	29.48	18034455
442	Phosphorylation	RQSNHTFSSGDITPY CCCCCCCCCCCCCHH	34.27	18034455
449	Phosphorylation	SSGDITPYTKLCCKG CCCCCCHHHHHHHHH	14.09	18034455
539	N-linked_Glycosylation	SVMVARSNGTVSPSA EEEEEECCCCCCHHH	44.60	-
685	N-linked_Glycosylation	FRFGTVPNGSTERNI CCCCCCCCCCCCCCH	53.35	-
716	Phosphorylation	RSVEDALTSLKMGKL HCHHHHHHHHHCCCC	33.46	28576409
875	Phosphorylation	NGVQSLPSPARPPSP CCHHHCCCCCCCCCC	36.16	22817900
881	Phosphorylation	PSPARPPSPDLTAGS CCCCCCCCCCCCCCH	33.46	22817900
905	Phosphorylation	QAARDMVSTADVSGS HHHHHHHHHCCCCCC	15.96	29899451
906	Phosphorylation	AARDMVSTADVSGSL HHHHHHHHCCCCCCH	18.57	29899451
910	Phosphorylation	MVSTADVSGSLDRAT HHHHCCCCCCHHHHH	24.18	25521595
912	Phosphorylation	STADVSGSLDRATRT HHCCCCCCHHHHHHH	21.42	25521595
976	Phosphorylation	QPPARPATCAGSPQP CCCCCCCCCCCCCCC	12.93	25521595
980	Phosphorylation	RPATCAGSPQPDVSR CCCCCCCCCCCCCCH	11.22	22817900
986	Phosphorylation	GSPQPDVSRASCRHA CCCCCCCCHHHHHHH	29.52	29899451
1012	Phosphorylation	QGSHLSASERRALPE CCCCCCHHHHCCCCH	28.41	-
1030	Phosphorylation	LHAHCHYSSFPRAER HHHHCCHHCCCCHHH	11.22	22807455
1031	Phosphorylation	HAHCHYSSFPRAERS HHHCCHHCCCCHHHC	31.91	22807455
1084	Phosphorylation	GPRPRHASLPSSVAE CCCCCCCCCCHHHHH	34.39	29899451
1132	Phosphorylation	TQSLRLPSYREACVE CCCCCCCCHHHHHHC	41.22	24719451
1233	Phosphorylation	SCTWRRISSLESEV- CCCCHHHHHHHCCC-	27.36	29899451
1234	Phosphorylation	CTWRRISSLESEV-- CCCHHHHHHHCCC--	33.51	25521595
1237	Phosphorylation	RRISSLESEV----- HHHHHHHCCC-----	49.29	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1084	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMDE3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMDE3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NMDE3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.