UniProt ID | BEGIN_MOUSE | |
---|---|---|
UniProt AC | Q68EF6 | |
Protein Name | Brain-enriched guanylate kinase-associated protein | |
Gene Name | Begain | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 600 | |
Subcellular Localization |
Cytoplasm. Membrane Peripheral membrane protein. |
|
Protein Description | May sustain the structure of the postsynaptic density (PSD).. | |
Protein Sequence | MEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELDKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRAMSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQQRVSLHMEKHGCSLPSALCHPAYADSVPTCVIAKVLEKPDPGSLSSRMSDASARDLGYRDGVEKSGPRPPYKGDIYCSDPALYCPDEREHARRPSVDTPVTDVGFLRAQNSTDSAAEEEEEAEAAAFPEAYRREAYQGYAASLPTSSSYSSFSATSEEKEHAQAGTLTASQQAIYLSSRDEFFNRKPSATYGSGPRFAKAASTLGSPLEAQVAPGFARTVSPYPAEPYRYPASPGPQQALMPPNLWSLRAKPSGNRLAGEDIRGQWRPVSVEDVGAYSYQAGAAAGRAASPCNYSERYYGGGGGGGAAGGGSPGDKAEGRASPLYATYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPSRSADALAGYAASDGDGDRLRVQLCGAGSSPEPEHGSRESLEPSSMEASPEMHPPTRLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
1 | Acetylation | -------MEKLSALQ -------CHHHHHHH | 10.39 | - | |
16 | Phosphorylation | EQKGELRKRLSYTTH HHHHHHHHHHHHHHH | 71.02 | - | |
19 | Phosphorylation | GELRKRLSYTTHKLE HHHHHHHHHHHHHHH | 25.19 | 29899451 | |
21 | Phosphorylation | LRKRLSYTTHKLEKL HHHHHHHHHHHHHHH | 21.03 | 25338131 | |
62 | Phosphorylation | EKLRRIQSNYMALQR HHHHHHHHHHHHHHH | 27.79 | 30635358 | |
64 | Phosphorylation | LRRIQSNYMALQRIN HHHHHHHHHHHHHHH | 6.76 | 30635358 | |
77 | Ubiquitination | INQELEDKLYRMGQH HHHHHHHHHHHCHHH | 37.73 | - | |
136 | Phosphorylation | QLLQCSQTYGRVHKV HHHHHHHHHCCCEEH | 16.20 | 29899451 | |
137 | Phosphorylation | LLQCSQTYGRVHKVS HHHHHHHHCCCEEHH | 8.69 | 29899451 | |
194 | Phosphorylation | LEKPDPGSLSSRMSD HCCCCCCCHHHHCCH | 30.39 | 20415495 | |
196 | Phosphorylation | KPDPGSLSSRMSDAS CCCCCCHHHHCCHHH | 20.00 | 21183079 | |
197 | Phosphorylation | PDPGSLSSRMSDASA CCCCCHHHHCCHHHH | 36.98 | 21183079 | |
200 | Phosphorylation | GSLSSRMSDASARDL CCHHHHCCHHHHHHH | 28.99 | 21183079 | |
227 | Phosphorylation | PPYKGDIYCSDPALY CCCCCCEEECCCCCC | 7.22 | 19060867 | |
229 | Phosphorylation | YKGDIYCSDPALYCP CCCCEEECCCCCCCC | 29.65 | 25521595 | |
234 | Phosphorylation | YCSDPALYCPDEREH EECCCCCCCCCHHHH | 12.21 | 29899451 | |
246 | Phosphorylation | REHARRPSVDTPVTD HHHCCCCCCCCCCCH | 30.71 | 25521595 | |
249 | Phosphorylation | ARRPSVDTPVTDVGF CCCCCCCCCCCHHHH | 19.94 | 18056256 | |
252 | Phosphorylation | PSVDTPVTDVGFLRA CCCCCCCCHHHHHHC | 26.60 | 21183079 | |
262 | Phosphorylation | GFLRAQNSTDSAAEE HHHHCCCCCCCHHHH | 22.85 | 25521595 | |
263 | Phosphorylation | FLRAQNSTDSAAEEE HHHCCCCCCCHHHHH | 41.33 | 19060867 | |
265 | Phosphorylation | RAQNSTDSAAEEEEE HCCCCCCCHHHHHHH | 29.48 | 25521595 | |
302 | Phosphorylation | PTSSSYSSFSATSEE CCCCCCCCCCCCHHH | 18.26 | 29899451 | |
317 | Phosphorylation | KEHAQAGTLTASQQA HHHHHHCCCCHHHHH | 24.77 | 29899451 | |
319 | Phosphorylation | HAQAGTLTASQQAIY HHHHCCCCHHHHHHH | 24.89 | 29899451 | |
321 | Phosphorylation | QAGTLTASQQAIYLS HHCCCCHHHHHHHHH | 20.00 | 25521595 | |
326 | Phosphorylation | TASQQAIYLSSRDEF CHHHHHHHHHCHHHH | 11.98 | 30635358 | |
328 | Phosphorylation | SQQAIYLSSRDEFFN HHHHHHHHCHHHHHC | 13.32 | 30635358 | |
329 | Phosphorylation | QQAIYLSSRDEFFNR HHHHHHHCHHHHHCC | 40.95 | 30635358 | |
341 | Phosphorylation | FNRKPSATYGSGPRF HCCCCCCCCCCCHHH | 32.52 | - | |
344 | Phosphorylation | KPSATYGSGPRFAKA CCCCCCCCCHHHHHH | 34.90 | - | |
353 | Phosphorylation | PRFAKAASTLGSPLE HHHHHHHHHHCCCHH | 29.08 | 25521595 | |
354 | Phosphorylation | RFAKAASTLGSPLEA HHHHHHHHHCCCHHH | 30.34 | 29899451 | |
357 | Phosphorylation | KAASTLGSPLEAQVA HHHHHHCCCHHHHCC | 29.44 | 18056256 | |
372 | Phosphorylation | PGFARTVSPYPAEPY CCCCCCCCCCCCCCC | 20.36 | - | |
380 | Asymmetric dimethylarginine | PYPAEPYRYPASPGP CCCCCCCCCCCCCCC | 41.49 | - | |
380 | Methylation | PYPAEPYRYPASPGP CCCCCCCCCCCCCCC | 41.49 | 24129315 | |
384 | Phosphorylation | EPYRYPASPGPQQAL CCCCCCCCCCCCCCC | 26.36 | - | |
421 | Phosphorylation | RGQWRPVSVEDVGAY CCCEECCCHHHHCCE | 23.59 | 30635358 | |
428 | Phosphorylation | SVEDVGAYSYQAGAA CHHHHCCEEEHHHCC | 11.28 | 21183079 | |
429 | Phosphorylation | VEDVGAYSYQAGAAA HHHHCCEEEHHHCCC | 15.38 | 30635358 | |
430 | Phosphorylation | EDVGAYSYQAGAAAG HHHCCEEEHHHCCCC | 6.95 | 30635358 | |
441 | Phosphorylation | AAAGRAASPCNYSER CCCCCCCCCCCCCCC | 29.06 | 25521595 | |
445 | Phosphorylation | RAASPCNYSERYYGG CCCCCCCCCCCCCCC | 20.73 | 30635358 | |
446 | Phosphorylation | AASPCNYSERYYGGG CCCCCCCCCCCCCCC | 11.12 | 30635358 | |
450 | Phosphorylation | CNYSERYYGGGGGGG CCCCCCCCCCCCCCC | 18.60 | 29899451 | |
463 | Phosphorylation | GGAAGGGSPGDKAEG CCCCCCCCCCCCCCC | 29.05 | 22324799 | |
473 | Phosphorylation | DKAEGRASPLYATYK CCCCCCCCCCEEEEE | 17.68 | 25521595 | |
476 | Phosphorylation | EGRASPLYATYKADS CCCCCCCEEEEECCC | 10.57 | 25521595 | |
478 | Phosphorylation | RASPLYATYKADSFS CCCCCEEEEECCCCC | 16.40 | 22324799 | |
479 | Phosphorylation | ASPLYATYKADSFSE CCCCEEEEECCCCCC | 8.94 | 22324799 | |
483 | Phosphorylation | YATYKADSFSEGDDL EEEEECCCCCCCCCC | 35.22 | 22324799 | |
485 | Phosphorylation | TYKADSFSEGDDLSQ EEECCCCCCCCCCCC | 44.62 | 25521595 | |
491 | Phosphorylation | FSEGDDLSQGHLAEP CCCCCCCCCCCCCCC | 40.90 | 25521595 | |
508 | Phosphorylation | LRAGGDLSLSPSRSA EECCCCCCCCCCCCH | 31.38 | 21743459 | |
510 | Phosphorylation | AGGDLSLSPSRSADA CCCCCCCCCCCCHHH | 19.90 | 22324799 | |
512 | Phosphorylation | GDLSLSPSRSADALA CCCCCCCCCCHHHHC | 35.18 | 20415495 | |
514 | Phosphorylation | LSLSPSRSADALAGY CCCCCCCCHHHHCCC | 34.53 | - | |
521 | Phosphorylation | SADALAGYAASDGDG CHHHHCCCCCCCCCC | 8.06 | 29899451 | |
524 | Phosphorylation | ALAGYAASDGDGDRL HHCCCCCCCCCCCEE | 33.67 | 25521595 | |
540 | Phosphorylation | VQLCGAGSSPEPEHG EEECCCCCCCCCCCC | 42.03 | 22324799 | |
541 | Phosphorylation | QLCGAGSSPEPEHGS EECCCCCCCCCCCCC | 32.15 | 22324799 | |
548 | Phosphorylation | SPEPEHGSRESLEPS CCCCCCCCCCCCCCC | 34.48 | 25367039 | |
551 | Phosphorylation | PEHGSRESLEPSSME CCCCCCCCCCCCCCC | 36.60 | 25367039 | |
555 | Phosphorylation | SRESLEPSSMEASPE CCCCCCCCCCCCCCC | 32.70 | 25367039 | |
556 | Phosphorylation | RESLEPSSMEASPEM CCCCCCCCCCCCCCC | 31.21 | 25367039 | |
560 | Phosphorylation | EPSSMEASPEMHPPT CCCCCCCCCCCCCCC | 14.21 | 25367039 | |
567 | Phosphorylation | SPEMHPPTRLSPQQA CCCCCCCCCCCHHHC | 49.01 | 25367039 | |
570 | Phosphorylation | MHPPTRLSPQQAFPR CCCCCCCCHHHCCCC | 19.85 | 20415495 | |
588 | Phosphorylation | SGLSRKDSLTKAQLY CCCCCHHHCCHHHHH | 40.76 | 29514104 | |
595 | Phosphorylation | SLTKAQLYGTLLN-- HCCHHHHHHHHCC-- | 8.93 | 25521595 | |
597 | Phosphorylation | TKAQLYGTLLN---- CHHHHHHHHCC---- | 17.95 | 20415495 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BEGIN_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BEGIN_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BEGIN_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of BEGIN_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265; SER-357 ANDSER-473, AND MASS SPECTROMETRY. | |
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194 AND SER-246, ANDMASS SPECTROMETRY. | |
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-137, AND MASSSPECTROMETRY. |