GRIK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRIK2_MOUSE
• UniProt AC: P39087
• Protein Name: Glutamate receptor ionotropic, kainate 2
• Gene Name: Grik2
• Organism: Mus musculus (Mouse).
• Sequence Length: 908
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2..
• Protein Sequence: MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Acetylation	LVFSRSIKVLLCLLW HHHHHHHHHHHHHHH	28.24	15612419
67	N-linked_Glycosylation	AVNTINRNRTLLPNT HHHHCCCCCCCCCCC	36.48	-
73	N-linked_Glycosylation	RNRTLLPNTTLTYDT CCCCCCCCCEEEECC	45.74	-
193	Phosphorylation	QELIKAPSRYNLRLK HHHHHCCCCCCCEEE	52.86	-
195	Phosphorylation	LIKAPSRYNLRLKIR HHHCCCCCCCEEEEE	23.92	-
212	Acetylation	PADTKDAKPLLKEMK CCCCCCCHHHHHHHH	46.46	7632025
222	Acetylation	LKEMKRGKEFHVIFD HHHHHCCCCEEEEEE	62.33	7632037
275	N-linked_Glycosylation	PYRYSGVNMTGFRIL CCCCCCCCCCCEEEE	26.31	-
358	Methylation	KPWRFGTRFMSLIKE CCCCCHHHHHHHHHH	26.16	-
378	N-linked_Glycosylation	LTGRITFNKTNGLRT CCCEEEEECCCCCCC	41.41	-
385	Phosphorylation	NKTNGLRTDFDLDVI ECCCCCCCCCEEEEE	46.17	29899451
412	N-linked_Glycosylation	WDPSSGLNMTESQKG CCCCCCCCCCHHHCC	38.56	-
423	N-linked_Glycosylation	SQKGKPANITDSLSN HHCCCCCCCCHHCCC	46.34	-
430	N-linked_Glycosylation	NITDSLSNRSLIVTT CCCHHCCCCCEEEEE	42.74	-
546	N-linked_Glycosylation	SILYRKPNGTNPGVF EEEEECCCCCCCCHH	73.32	-
751	N-linked_Glycosylation	FVTQRNCNLTQIGGL EECCCCCCEEEECCE	50.07	-
846	Phosphorylation	VGEFLYKSKKNAQLE HHHHHHHCCCCHHHH	34.99	22817900
856	Phosphorylation	NAQLEKRSFCSAMVE CHHHHHHHHHHHHHH	41.49	29550500
858	S-palmitoylation	QLEKRSFCSAMVEEL HHHHHHHHHHHHHHH	2.40	28680068
859	Phosphorylation	LEKRSFCSAMVEELR HHHHHHHHHHHHHHH	19.86	29550500
868	Phosphorylation	MVEELRMSLKCQRRL HHHHHHHHHHHHHHH	20.45	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
846	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
846	S	Phosphorylation	Kinase	PKC	-	Uniprot
868	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
868	S	Phosphorylation	Kinase	PKC	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Klhl17	Q6TDP3	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
868	S	Phosphorylation	Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation.	-
868	S	Sumoylation	Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRIK2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRIK3_MOUSE	Grik3	physical	15805114

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.