GRIK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRIK3_MOUSE
• UniProt AC: B1AS29
• Protein Name: Glutamate receptor ionotropic, kainate 3
• Gene Name: Grik3
• Organism: Mus musculus (Mouse).
• Sequence Length: 919
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity)..
• Protein Sequence: MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWAMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPVFP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	N-linked_Glycosylation	SANIINRNRTLLPNT HHHHHCCCCCCCCCC	36.48	-
76	N-linked_Glycosylation	RNRTLLPNTTLTYDI CCCCCCCCCEEEEEE	45.74	-
278	N-linked_Glycosylation	PYRYSGVNLTGFRIL CCCCCCCCCCCEEEE	35.10	-
367	Phosphoglycerylation	GRFMNFIKEAQWEGL CHHHHHHHHHHHCCC	42.74	-
381	N-linked_Glycosylation	LTGRIVFNKTSGLRT CCCEEEEECCCCCCC	35.48	-
415	N-linked_Glycosylation	WSPADGLNITEVAKG ECCCCCCCHHHHHCC	44.67	-
426	N-linked_Glycosylation	VAKGRGPNVTDSLTN HHCCCCCCCHHHCCC	52.74	-
433	N-linked_Glycosylation	NVTDSLTNRSLIVTT CCHHHCCCCCEEEEE	36.52	-
548	N-linked_Glycosylation	SILYRKPNGTNPSVF EEEEECCCCCCCHHH	73.32	-
551	N-linked_Glycosylation	YRKPNGTNPSVFSFL EECCCCCCCHHHHHC	28.40	-
702	Phosphorylation	FFKKSKISTFEKMWA EEEHHCCCHHHHHHH	30.68	28973931
752	N-linked_Glycosylation	YITQRNCNLTQIGGL HHHHCCCCCEEECCE	50.07	-
796	Sumoylation	EDKLHIMKEKWWRGS HHCCEECCHHHCCCC	56.38	28289178
859	S-palmitoylation	EREQRSFCSTVADEI HHHHHHHHHHHHHHH	3.34	28680068
869	Phosphorylation	VADEIRFSLTCQRRL HHHHHHHHHHHHHHH	16.96	-
872	S-palmitoylation	EIRFSLTCQRRLKHK HHHHHHHHHHHHCCC	3.43	28680068
907	O-linked_Glycosylation	RRLPGKDSMSCSTSL CCCCCCCCCCCCCCC	18.97	55412123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRIK3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRIK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRIK3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRIK2_MOUSE	Grik2	physical	15805114

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.