KCNA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNA3_MOUSE
• UniProt AC: P16390
• Protein Name: Potassium voltage-gated channel subfamily A member 3
• Gene Name: Kcna3
• Organism: Mus musculus (Mouse).
• Sequence Length: 528
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient..
• Protein Sequence: MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	PPQGGCGSGGGGGGC CCCCCCCCCCCCCCC	38.04	-
232	N-linked_Glycosylation	DVFEAANNSTSGAPS HHHHHHHCCCCCCCC	41.77	-
270	S-palmitoylation	LLVRFFACPSKATFS HHHHHHCCCCCCHHC	3.10	-
438	Phosphorylation	VIVSNFNYFYHRETE EEEECCCEEEECCCC	11.02	-
444	Phosphorylation	NYFYHRETEGEEQAQ CEEEECCCCCHHHHH	49.61	17114649
452	Phosphorylation	EGEEQAQYMHVGSCQ CCHHHHHEEEHHHHH	7.69	19060867
457	Phosphorylation	AQYMHVGSCQHLSSS HHEEEHHHHHHHCCC	14.98	22817900
462	Phosphorylation	VGSCQHLSSSAEELR HHHHHHHCCCHHHHH	21.81	21183079
463	Phosphorylation	GSCQHLSSSAEELRK HHHHHHCCCHHHHHH	39.67	29899451
464	Phosphorylation	SCQHLSSSAEELRKA HHHHHCCCHHHHHHH	36.00	22817900
473	Phosphorylation	EELRKARSNSTLSKS HHHHHHHCCCCCCHH	39.74	29899451
480	Phosphorylation	SNSTLSKSEYMVIEE CCCCCCHHHEEEEEC	30.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
473	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNA3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KCNA3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.