LPPRC_MOUSE - dbPTM
LPPRC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LPPRC_MOUSE
UniProt AC Q6PB66
Protein Name Leucine-rich PPR motif-containing protein, mitochondrial
Gene Name Lrpprc
Organism Mus musculus (Mouse).
Sequence Length 1392
Subcellular Localization Mitochondrion. Nucleus . Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane.
Protein Description May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA..
Protein Sequence MAALLRPARWLLGAAAAPRLPLSLRLPAGVPGRLSSVVRVAAVGSRPAAGERLSQARLYAIVAEKRDLQEEPAPVRKNSSQFDWALMRLDNSVRRTGRITKGLLQRVFESTCSSGSPGSNQALLLLRSCGSLLPELSLAERTEFAHKIWDKLQQLGVVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEGANIQPNRVTYQRLIAAYCNVGDIEGASKILGFMKTKDLPITEAVFSALVTGHARAGDMENAENILTVMKQAGIEPGPDTYLALLNAHAERGDIGQVRQILEKVEKSDHYFMDRDFLQVIFSFSKAGYPQYVSEILEKITYERRSIPDAMNLILFLATEKLEDTAFQVLLALPLSKDESSDNFGSFFLRHCVTLDLPPEKLIDYCRRLRDAKLHSSSLQFTLHCALQANRTALAKAVMEALREEGFPIRPHYFWPLLAGHQKTKNVQGIIDILKIMNKVGVDPDQETYINYVFPCFDSAQSVRAALQENECLLASSTFAQAEVKNEAINGNLQNILSFLESNTLPFSFSSLRNSLILGFRRSMNIDLWSKITELLYKDERYCSKPPGPAEAVGYFLYNLIDSMSDSEVQAKEERLRQYFHQLQEMNVKVPENIYKGICNLLNTYHVPELIKDIKVLVDREKVDSQKTSQVTSSDLESTLEKLKAEGQPVGSALKQLLLLLCSEENMQKALEVKAKYESDMVIGGYAALINLCCRHDNAEDAWNLKQEVDRLDASAILDTAKYVALVKVLGKHSRLQDAINILKEMKEKDVVIKDATVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHLEKGDLPAALEASIACHKKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIASNQVEALEKLVELTEKLFECDRDQMYYNLLKLYKISSDWQRADAAWTKMQEENIIPRERTLRLLAEILKTSNQEVPFDVPELWFGDDRPSLSPSSRSAGEDVTEKTLLSNCKLKKSKDAYNIFLKAEKQNVVFSSETYSTLIGLLLSKDDFTQAMHVKDFAETHIKGFTLNDAANSLLIIRQVRRDYLKGALATLRAALDLKQVPSQIAVTRLIQALALKGDVESIEAIQRMVAGLDTIGLSKMVFINNIALAQMKNNKLDAAIENIEHLLASENQAIEPQYFGLSYLFRKVIEEQMEPALEKLSIMSERMANQFALYKPVTDLFLQLVDSGKVDEARALLERCGAIAEQSSLLSVFCLRTSQKPKKAPVLKTLLELIPELRDNDKVYSCSMKSYALDKDVASAKALYEYLTAKNLKLDDLFLKRYAALLKDVGEPVPFPEPPESFAFYIKQLKEARESPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationAAPRLPLSLRLPAGV
HCCCCCEEEECCCCC		14.9825890499
35PhosphorylationAGVPGRLSSVVRVAA
CCCCCCHHHEEEEEE		21.5221149613
36PhosphorylationGVPGRLSSVVRVAAV
CCCCCHHHEEEEEEC		29.2621149613
79PhosphorylationPAPVRKNSSQFDWAL
CCCCCCCCHHHCHHH		28.6622817900
80PhosphorylationAPVRKNSSQFDWALM
CCCCCCCHHHCHHHH		44.2319060867
112GlutathionylationQRVFESTCSSGSPGS
HHHHHHHCCCCCCCH		4.1924333276
112S-nitrosocysteineQRVFESTCSSGSPGS
HHHHHHHCCCCCCCH		4.19-
112S-palmitoylationQRVFESTCSSGSPGS
HHHHHHHCCCCCCCH		4.1928526873
112S-nitrosylationQRVFESTCSSGSPGS
HHHHHHHCCCCCCCH		4.1921278135
129S-nitrosocysteineALLLLRSCGSLLPEL
HHHHHHHHCHHHHHC		3.29-
129S-palmitoylationALLLLRSCGSLLPEL
HHHHHHHHCHHHHHC		3.2928526873
129S-nitrosylationALLLLRSCGSLLPEL
HHHHHHHHCHHHHHC		3.2921278135
147AcetylationERTEFAHKIWDKLQQ
HHHHHHHHHHHHHHH		41.9023201123
147SuccinylationERTEFAHKIWDKLQQ
HHHHHHHHHHHHHHH		41.9023954790
151AcetylationFAHKIWDKLQQLGVV
HHHHHHHHHHHHCCE		32.9523576753
177SuccinylationVYLQNEYKFSPTDFL
HHHCCCCCCCHHHHH		32.9423954790
186AcetylationSPTDFLAKMEGANIQ
CHHHHHHHHCCCCCC		39.3623576753
186SuccinylationSPTDFLAKMEGANIQ
CHHHHHHHHCCCCCC		39.3623954790
207GlutathionylationQRLIAAYCNVGDIEG
HHHHHHHCCCCCCCC		2.5924333276
207S-palmitoylationQRLIAAYCNVGDIEG
HHHHHHHCCCCCCCC		2.5928526873
207S-nitrosocysteineQRLIAAYCNVGDIEG
HHHHHHHCCCCCCCC		2.59-
207S-nitrosylationQRLIAAYCNVGDIEG
HHHHHHHCCCCCCCC		2.5921278135
223AcetylationSKILGFMKTKDLPIT
HHHHCCCCCCCCCCC		50.6023201123
225AcetylationILGFMKTKDLPITEA
HHCCCCCCCCCCCHH		52.3123576753
258AcetylationENILTVMKQAGIEPG
HHHHHHHHHCCCCCC		32.4323954790
291AcetylationQVRQILEKVEKSDHY
HHHHHHHHHHCCCCC		52.8523864654
462AcetylationQGIIDILKIMNKVGV
HHHHHHHHHHHHHCC		40.0023576753
483S-nitrosylationYINYVFPCFDSAQSV
CHHHHHHCCCCHHHH		3.9321278135
483S-nitrosocysteineYINYVFPCFDSAQSV
CHHHHHHCCCCHHHH		3.93-
483GlutathionylationYINYVFPCFDSAQSV
CHHHHHHCCCCHHHH		3.9324333276
557PhosphorylationSMNIDLWSKITELLY
HCCHHHHHHHHHHHH		22.83-
565AcetylationKITELLYKDERYCSK
HHHHHHHCCCCCCCC		53.7523201123
626S-palmitoylationENIYKGICNLLNTYH
CHHHHHHHHHHHHCC		3.9128526873
642AcetylationPELIKDIKVLVDREK
HHHHHHCEEEECHHH		39.3823864654
661PhosphorylationKTSQVTSSDLESTLE
CHHCCCHHHHHHHHH		36.5326525534
665PhosphorylationVTSSDLESTLEKLKA
CCHHHHHHHHHHHHH		45.6625338131
666PhosphorylationTSSDLESTLEKLKAE
CHHHHHHHHHHHHHC		29.5725338131
669AcetylationDLESTLEKLKAEGQP
HHHHHHHHHHHCCCC		59.4023864654
749AcetylationSAILDTAKYVALVKV
HHHHHHHHHHHHHHH		42.2123576753
755AcetylationAKYVALVKVLGKHSR
HHHHHHHHHHCCCHH		32.3722826441
771SuccinylationQDAINILKEMKEKDV
HHHHHHHHHHHHCCC		52.5523954790
847S-nitrosylationALEASIACHKKYKVL
HHHHHHHHHHHHCCC		4.6320925432
847S-nitrosocysteineALEASIACHKKYKVL
HHHHHHHHHHHHCCC		4.63-
849AcetylationEASIACHKKYKVLPR
HHHHHHHHHHCCCHH		58.6523576753
863AcetylationRIHDVLCKLVEKGET
HHHHHHHHHHHCCCH		51.9423201123
867AcetylationVLCKLVEKGETDLIQ
HHHHHHHCCCHHHHH		55.3523864654
929S-nitrosocysteineLQWFCDRCIASNQVE
HHHHHHHHHHHCHHH		1.62-
929S-nitrosylationLQWFCDRCIASNQVE
HHHHHHHHHHHCHHH		1.6221278135
965AcetylationYNLLKLYKISSDWQR
HHHHHHHHCCCCHHH		46.6923806337
965SuccinylationYNLLKLYKISSDWQR
HHHHHHHHCCCCHHH		46.6923806337
1001PhosphorylationLLAEILKTSNQEVPF
HHHHHHHHCCCCCCC		29.4823984901
1002PhosphorylationLAEILKTSNQEVPFD
HHHHHHHCCCCCCCC		34.6223984901
1021PhosphorylationWFGDDRPSLSPSSRS
CCCCCCCCCCCCCCC		42.2329895711
1023PhosphorylationGDDRPSLSPSSRSAG
CCCCCCCCCCCCCCC		27.3726745281
1025PhosphorylationDRPSLSPSSRSAGED
CCCCCCCCCCCCCCC		34.7023984901
1026PhosphorylationRPSLSPSSRSAGEDV
CCCCCCCCCCCCCCC		33.3726643407
1028PhosphorylationSLSPSSRSAGEDVTE
CCCCCCCCCCCCCCH		42.4423984901
1034PhosphorylationRSAGEDVTEKTLLSN
CCCCCCCCHHHHHHC		44.0523984901
1036AcetylationAGEDVTEKTLLSNCK
CCCCCCHHHHHHCCC		34.8023864654
1048AcetylationNCKLKKSKDAYNIFL
CCCCCCCHHHHHHHH		56.0823201123
1056SuccinylationDAYNIFLKAEKQNVV
HHHHHHHHHHHHCEE		43.6923954790
1056AcetylationDAYNIFLKAEKQNVV
HHHHHHHHHHHHCEE		43.6923864654
1065PhosphorylationEKQNVVFSSETYSTL
HHHCEEECCCCHHHH		18.6920531401
1089AcetylationFTQAMHVKDFAETHI
CCCCHHHHHHHHHHC		32.2423954790
1094PhosphorylationHVKDFAETHIKGFTL
HHHHHHHHHCCCEEH		26.0220531401
1120AcetylationQVRRDYLKGALATLR
HHHHHHHHHHHHHHH		35.5923806337
1120SuccinylationQVRRDYLKGALATLR
HHHHHHHHHHHHHHH		35.5923806337
1133AcetylationLRAALDLKQVPSQIA
HHHHCCCCCCCHHHH		49.2523864654
1137PhosphorylationLDLKQVPSQIAVTRL
CCCCCCCHHHHHHHH		35.05-
1317AcetylationPELRDNDKVYSCSMK
HHHCCCCCEEECCCH		49.6922826441
1321S-nitrosylationDNDKVYSCSMKSYAL
CCCCEEECCCHHHCC		2.2321278135
1321S-nitrosocysteineDNDKVYSCSMKSYAL
CCCCEEECCCHHHCC		2.23-
1330AcetylationMKSYALDKDVASAKA
CHHHCCCCCHHHHHH		55.7623201123
1390PhosphorylationQLKEARESPS-----
HHHHHHHCCC-----		25.5325338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LPPRC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LPPRC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LPPRC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FOXO1_MOUSEFoxo1physical
17050673
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LPPRC_MOUSE

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Related Literatures of Post-Translational Modification

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