PLPP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPP3_MOUSE
• UniProt AC: Q99JY8
• Protein Name: Phospholipid phosphatase 3 {ECO:0000250|UniProtKB:O14495}
• Gene Name: Plpp3 {ECO:0000250|UniProtKB:O14495}
• Organism: Mus musculus (Mouse).
• Sequence Length: 312
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P) (By similarity). Essential to the formation of the chorioallantoic placenta and extraembryonic vasculature. Also mediates gastrulation and axis formation, probably by regulating the Wnt signaling pathway..
• Protein Sequence: MQSYKYDKAIVPESKNGGSPALNNNPRKGGSKRVLLICLDLFCLFMAALPFLIIETSTIKPYRRGFYCNDESIKYPLKVSETINDAVLCAVGIVIAILAIITGEFYRIYYLKEKSRSTTQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCDPDFSQINCSEGYIQNYRCRGEDSKVQEARKSFFSGHASFSMFTMLYLVLYLQARFTWRGARLLRPLLQFTLLMMAFYTGLSRVSDYKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTSLSLPAPAIRREILSPVDIIDRNNHHNMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MQSYKYDKAI -----CCCCCCCCCC		26643407
4	Phosphorylation	----MQSYKYDKAIV ----CCCCCCCCCCC		29514104
6	Phosphorylation	--MQSYKYDKAIVPE --CCCCCCCCCCCCC		29514104
8	Ubiquitination	MQSYKYDKAIVPESK CCCCCCCCCCCCCCC		27667366
14	Phosphorylation	DKAIVPESKNGGSPA CCCCCCCCCCCCCCC		29514104
15	Ubiquitination	KAIVPESKNGGSPAL CCCCCCCCCCCCCCC		27667366
19	Phosphorylation	PESKNGGSPALNNNP CCCCCCCCCCCCCCC		25521595
74	Acetylation	YCNDESIKYPLKVSE CCCCCCCCCCCCCCC		23806337
112	Ubiquitination	FYRIYYLKEKSRSTT HHHEEEEHHHCCCCC		27667366
171	N-linked_Glycosylation	DPDFSQINCSEGYIQ CCCHHHCCCCCCCCC		-
282	Ubiquitination	VSDLFKTKTSLSLPA HHHHHCCCCCCCCCH		27667366
286	Phosphorylation	FKTKTSLSLPAPAIR HCCCCCCCCCHHHHH		25338131
298	Phosphorylation	AIRREILSPVDIIDR HHHHHHCCCCCEECC		26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPP3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPP3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLPP3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.