ANS1A_MOUSE - dbPTM
ANS1A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ANS1A_MOUSE
UniProt AC P59672
Protein Name Ankyrin repeat and SAM domain-containing protein 1A
Gene Name Anks1a
Organism Mus musculus (Mouse).
Sequence Length 1150
Subcellular Localization Cytoplasm. Cell projection . Cytoplasmic before and after growth factor treatment..
Protein Description Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction..
Protein Sequence MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGSGSGGGSGGGGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHRDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIQQGPSHTRVNEQNALEIRELKKYGPFDPYINAKNNDNETALHCAAQYGHTEVVKALLEELTDPTMRNNKFETPLDLAALYGRLEVVKLLLGAHPNLLSCSTRKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGIDVNIKDNRGLTALDTVRDLPSQKSQQIAALIEDHMTGKRSVKEVDRTSTAQLPLLSNTDAIAPMSQGSMEKTVTELILHFDTHADEEGPYEALYNAVSCHSLDSTASGRSSDRDSMNKEAEATGTRAAGVRPRERPPPPAKPPPDEEEEERVDKKYFPLAASEGLAVRPRIQSSAPQEEEEHPYELLLTAETKKLGTTDGRTEDHRQSGSGRSQDSVEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLTAPSQSHPESSQQDACHEASMQLEEPGVQGTEPPQPGVPDQSKRVGLPAGLTALASRTYLDALTHTVPLRPAGAEEEDQSGPRSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDEIEKIMSSIGEGIDFSQEQQKISGSRTLEQSVGEWLESIGLQQYESKLLLNGFDDVRFLGSNVMEEQDLREIGISDPQHRRKLLQAARSLPKVKALGYDGVSPTSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVHLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLISQTSSPLSQNDSCTGRSADLLLPSADTSRRRHDSLPDPGTASRADRFRVQEEPSETKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRTMAASAASMIETKSSKPVPKPRVGMRKSALEPPDSDQEAPSHASVSWIVDPKPDSKRSLSTN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MGKEQELLE
------CCHHHHHHH		54.21-
198UbiquitinationDPTMRNNKFETPLDL
CHHHCCCCCCCHHHH		48.39-
234PhosphorylationSCSTRKHTPLHLAAR
CCCCCCCCHHHHHHH		30.49-
312PhosphorylationRDLPSQKSQQIAALI
HCCCCHHHHHHHHHH		21.4923608596
328PhosphorylationDHMTGKRSVKEVDRT
HHHCCCCCCCCCCCC		40.8125266776
335PhosphorylationSVKEVDRTSTAQLPL
CCCCCCCCCCCCCCC		26.4329472430
336PhosphorylationVKEVDRTSTAQLPLL
CCCCCCCCCCCCCCC		23.7329472430
337PhosphorylationKEVDRTSTAQLPLLS
CCCCCCCCCCCCCCC		20.1529472430
356PhosphorylationIAPMSQGSMEKTVTE
CCCCCCCCHHHHHHH		19.0128285833
378PhosphorylationHADEEGPYEALYNAV
CCCCCCHHHHHHHHH		25.378502419
403PhosphorylationGRSSDRDSMNKEAEA
CCCCCHHHHCHHHHH		25.7525266776
444PhosphorylationEERVDKKYFPLAASE
HHHCCHHHHCCHHCC		19.0329514104
461PhosphorylationAVRPRIQSSAPQEEE
CCCCCCCCCCCCCCC		26.5425521595
462PhosphorylationVRPRIQSSAPQEEEE
CCCCCCCCCCCCCCC		27.8225521595
472PhosphorylationQEEEEHPYELLLTAE
CCCCCCCCHHHEEEE		22.5518515860
477PhosphorylationHPYELLLTAETKKLG
CCCHHHEEEECCCCC		23.5522499769
480PhosphorylationELLLTAETKKLGTTD
HHHEEEECCCCCCCC		30.8922499769
496PhosphorylationRTEDHRQSGSGRSQD
CCCCCCCCCCCCCCC		34.589847861
498PhosphorylationEDHRQSGSGRSQDSV
CCCCCCCCCCCCCCC		35.9611703635
501PhosphorylationRQSGSGRSQDSVEGQ
CCCCCCCCCCCCCCC		41.6962000363
504PhosphorylationGSGRSQDSVEGQDGQ
CCCCCCCCCCCCCCC		17.909840541
517PhosphorylationGQVPEQFSGLLHGSS
CCCCHHHHHHHCCCC		28.3862000369
523PhosphorylationFSGLLHGSSPVCEVG
HHHHHCCCCCCEECC		22.2622802335
524PhosphorylationSGLLHGSSPVCEVGQ
HHHHCCCCCCEECCC		26.4122802335
538PhosphorylationQDPFQLLTAPSQSHP
CCHHHHHCCCCCCCC		45.1522802335
541PhosphorylationFQLLTAPSQSHPESS
HHHHCCCCCCCCCCH		41.6822802335
543PhosphorylationLLTAPSQSHPESSQQ
HHCCCCCCCCCCHHH		45.4022802335
547PhosphorylationPSQSHPESSQQDACH
CCCCCCCCHHHHHHH		37.5922802335
548PhosphorylationSQSHPESSQQDACHE
CCCCCCCHHHHHHHH		30.1422802335
557PhosphorylationQDACHEASMQLEEPG
HHHHHHHHHCCCCCC		12.2222802335
589PhosphorylationVGLPAGLTALASRTY
CCCCHHHHHHHHHHH		20.7829472430
593PhosphorylationAGLTALASRTYLDAL
HHHHHHHHHHHHHHH		26.4627180971
621PhosphorylationEDQSGPRSRAPPTSK
CCCCCCCCCCCCCCC		35.6122807455
636PhosphorylationPKAELKLSRSLSKSD
CHHHHHHHHHCCCCH		20.4526824392
638PhosphorylationAELKLSRSLSKSDSD
HHHHHHHHCCCCHHH		33.3527087446
640PhosphorylationLKLSRSLSKSDSDLL
HHHHHHCCCCHHHCC		31.2126824392
642PhosphorylationLSRSLSKSDSDLLTC
HHHHCCCCHHHCCEE		38.6825521595
644PhosphorylationRSLSKSDSDLLTCSP
HHCCCCHHHCCEECC		36.9325521595
648PhosphorylationKSDSDLLTCSPTEDA
CCHHHCCEECCCCCC		20.4525619855
650PhosphorylationDSDLLTCSPTEDATM
HHHCCEECCCCCCCC		29.6225619855
652PhosphorylationDLLTCSPTEDATMGS
HCCEECCCCCCCCCC		30.1525619855
656PhosphorylationCSPTEDATMGSRSES
ECCCCCCCCCCCCHH		34.0925619855
659PhosphorylationTEDATMGSRSESLSN
CCCCCCCCCCHHHCC		23.0825619855
661PhosphorylationDATMGSRSESLSNCS
CCCCCCCCHHHCCCC		32.9827087446
663PhosphorylationTMGSRSESLSNCSIG
CCCCCCHHHCCCCCC		38.0425521595
665PhosphorylationGSRSESLSNCSIGKK
CCCCHHHCCCCCCHH		45.1023984901
668PhosphorylationSESLSNCSIGKKRLE
CHHHCCCCCCHHHHH		38.3325521595
677PhosphorylationGKKRLEKSPSFASEW
CHHHHHCCCCHHHCH		19.1924925903
679PhosphorylationKRLEKSPSFASEWDE
HHHHCCCCHHHCHHH		40.3024925903
682PhosphorylationEKSPSFASEWDEIEK
HCCCCHHHCHHHHHH		36.8924925903
692PhosphorylationDEIEKIMSSIGEGID
HHHHHHHHHHCCCCC		23.4427087446
693PhosphorylationEIEKIMSSIGEGIDF
HHHHHHHHHCCCCCC		19.7525521595
708PhosphorylationSQEQQKISGSRTLEQ
CHHHHHHCCCCHHHH		37.4423984901
710PhosphorylationEQQKISGSRTLEQSV
HHHHHCCCCHHHHHH		18.4624719451
712PhosphorylationQKISGSRTLEQSVGE
HHHCCCCHHHHHHHH		36.0223984901
716PhosphorylationGSRTLEQSVGEWLES
CCCHHHHHHHHHHHH		23.7823984901
746PhosphorylationDDVRFLGSNVMEEQD
CCCEECCCCCCCHHH		28.5325159016
850PhosphorylationASLADRPYEEPPQKP
HHHCCCCCCCCCCCC		33.5412745
886PhosphorylationNDSCTGRSADLLLPS
CCCCCCCCCCCCCCC		27.7227180971
903PhosphorylationTSRRRHDSLPDPGTA
CCCCCCCCCCCCCCC		35.3626824392
909PhosphorylationDSLPDPGTASRADRF
CCCCCCCCCCHHHHC		27.1825266776
911PhosphorylationLPDPGTASRADRFRV
CCCCCCCCHHHHCEE		28.0425266776
928PhosphorylationEPSETKLTLRPPSLA
CCCCCCCEECCCCCC		23.44101546347
933PhosphorylationKLTLRPPSLAAPYAP
CCEECCCCCCCCCCC		33.0781018459
938PhosphorylationPPSLAAPYAPVQSWQ
CCCCCCCCCCCCCCC		20.8629514104
996PhosphorylationEHMKKIPTIILSITY
HHHHCCCEEEEEEEE		24.9129895711
1002PhosphorylationPTIILSITYKGVKFI
CEEEEEEEECCCEEE		18.7929895711
1003PhosphorylationTIILSITYKGVKFID
EEEEEEEECCCEEEC		12.2229895711
1093PhosphorylationKSRTMAASAASMIET
HHHHHHHHHHHHHHC		18.1555444025
1100PhosphorylationSAASMIETKSSKPVP
HHHHHHHCCCCCCCC		25.8755446885
1116PhosphorylationPRVGMRKSALEPPDS
CCCCCCCCCCCCCCC		27.9381018475
1123PhosphorylationSALEPPDSDQEAPSH
CCCCCCCCCCCCCCC		47.1421743459
1129PhosphorylationDSDQEAPSHASVSWI
CCCCCCCCCCCEEEE		38.4421743459
1162 (in isoform 2)Ubiquitination--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ANS1A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ANS1A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ANS1A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ANS1A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ANS1A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682 AND SER-903, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640; SER-642; SER-644AND SER-663, AND MASS SPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-679, AND MASSSPECTROMETRY.

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