dbPTM

PGAM5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PGAM5_MOUSE
UniProt AC	Q8BX10
Protein Name	Serine/threonine-protein phosphatase PGAM5, mitochondrial
Gene Name	Pgam5
Organism	Mus musculus (Mouse).
Sequence Length	288
Subcellular Localization	Mitochondrion outer membrane Single-pass membrane protein.
Protein Description	Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore..
Protein Sequence	MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRGGGDADTRATEPPAWTGARAGRGVWDTNWDRREPLSLINLKKRNVESGEDELTSRLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAVETTDIISKHLPGVSRVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	LKKRNVESGEDELTS EHHCCCCCCCCHHHH	43.11	26525534
86	Phosphorylation	SGEDELTSRLDHYKA CCCCHHHHHHHHHHH	43.39	-
92	Acetylation	TSRLDHYKAKATRHI HHHHHHHHHHCCEEE	39.74	23864654
92 (in isoform 2)	Acetylation	-	39.74	-
94	Acetylation	RLDHYKAKATRHIFL HHHHHHHHCCEEEEE	46.25	23864654
112	Phosphorylation	SQYHVDGSLEKDRTL CEEECCCCCCCCCCC	28.97	-
115	Acetylation	HVDGSLEKDRTLTPL ECCCCCCCCCCCCCC	58.78	-
140	Ubiquitination	RLASLGLKFNKIVHS HHHHHCCCHHHHHHH	45.13	22790023
143	Acetylation	SLGLKFNKIVHSSMT HHCCCHHHHHHHHHC	49.60	-
147	Phosphorylation	KFNKIVHSSMTRAVE CHHHHHHHHHCCHHH	15.77	25338131
148	Phosphorylation	FNKIVHSSMTRAVET HHHHHHHHHCCHHHH	14.86	25338131
187	Phosphorylation	IEPDPPVSHWKPEAV CCCCCCCCCCCHHHH	29.42	23684622
187 (in isoform 2)	Phosphorylation	-	29.42	23684622
190	Acetylation	DPPVSHWKPEAVQYY CCCCCCCCHHHHHHH	27.79	23864654
190 (in isoform 2)	Acetylation	-	27.79	-
252	Phosphorylation	PEGWLRLSLNNGSIT CCCEEEEEECCCCEE	23.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Keap1	Q9Z2X8	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PGAM5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PGAM5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PGAM5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PGAM5_MOUSE

Related Literatures of Post-Translational Modification