ARPC4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARPC4_MOUSE
• UniProt AC: P59999
• Protein Name: Actin-related protein 2/3 complex subunit 4
• Gene Name: Arpc4
• Organism: Mus musculus (Mouse).
• Sequence Length: 168
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection.
• Protein Description: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity)..
• Protein Sequence: MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTATLRPYL ------CCCCHHHHH	28.48	-
2	Phosphorylation	------MTATLRPYL ------CCCCHHHHH	28.48	29514104
4	Phosphorylation	----MTATLRPYLSA ----CCCCHHHHHHH	17.71	26824392
10	Phosphorylation	ATLRPYLSAVRATLQ CCHHHHHHHHHHHHH	20.90	20415495
42	Phosphorylation	KPEVEVRSSKELLLQ CCCEEECCCHHEEEE	51.44	21082442
43	Phosphorylation	PEVEVRSSKELLLQP CCEEECCCHHEEEEE	21.42	19060867
44	Ubiquitination	EVEVRSSKELLLQPV CEEECCCHHEEEEEE	54.34	-
44	Acetylation	EVEVRSSKELLLQPV CEEECCCHHEEEEEE	54.34	22826441
44	Malonylation	EVEVRSSKELLLQPV CEEECCCHHEEEEEE	54.34	26320211
84	Acetylation	KQADEIEKILCHKFM ECHHHHHHHHHHHHH	46.79	22826441
89	Acetylation	IEKILCHKFMRFMMM HHHHHHHHHHHHHHH	39.60	22826441
166	Ubiquitination	IVAEEFLKNF----- HHHHHHHHCC-----	62.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARPC4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARPC4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARPC4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARPC4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.