NCAM1_MOUSE - dbPTM
NCAM1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NCAM1_MOUSE
UniProt AC P13595
Protein Name Neural cell adhesion molecule 1
Gene Name Ncam1
Organism Mus musculus (Mouse).
Sequence Length 1115
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein.
Isoform 2: Cell membrane
Single-pass type I membrane protein.
Isoform 3: Cell membrane
Lipid-anchor, GPI-anchor.
Protein Description This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc..
Protein Sequence MLRTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEFQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDEPEATGGVPILKYKAEWKSLGEESWHFKWYDAKEANMEGIVTIMGLKPETRYSVRLAALNGKGLGEISAATEFKTQPVREPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKYRALASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFLNKCGLLMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPELPADTTATVEDMLPSVTTVTTNSDTITETFATAQNSPTSETTTLTSSIAPPATTVPDSNSVPAGQATPSKGVTASSSSPASAPKVAPLVDLSDTPTSAPSASNLSSTVLANQGAVLSPSTPASAGETSKAPPASKASPAPTPTPAGAASPLAAVAAPATDAPQAKQEAPSTKGPDPEPTQPGTVKNPPEAATAPASPKSKAATTNPSQGEDLKMDEGNFKTPDIDLAKDVFAALGSPRPATGASGQASELAPSPADSAVPPAPAKTEKGPVETKSEPPESEAKPAPTEVKTVPNDATQTKENESKA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41S-nitrosylationGESKFFLCQVAGDAK
CCCEEEEEEECCCCC		2.3024895380
139S-nitrosylationGEDAVIVCDVVSSLP
CCCEEEEEECHHCCC		1.9524895380
186PhosphorylationIKKTDEGTYRCEGRI
CCCCCCCEEEECCEE		13.0229899451
222N-linked_GlycosylationQARQSIVNATANLGQ
HHHHHHHHHHCCCCC		29.8814658030
267PhosphorylationDDEKHIFSDDSSELT
CCCCCCCCCCCCCEE		39.6526525534
270PhosphorylationKHIFSDDSSELTIRN
CCCCCCCCCCEEEEE		30.6122324799
271PhosphorylationHIFSDDSSELTIRNV
CCCCCCCCCEEEEEC		43.5525521595
274PhosphorylationSDDSSELTIRNVDKN
CCCCCCEEEEECCCC		17.5322324799
288S-nitrosylationNDEAEYVCIAENKAG
CCCEEEEEEEECCCC		2.0922588120
316N-linked_GlycosylationPKITYVENQTAMELE
CEEEEEECCEEEEEE		34.1614658030
348N-linked_GlycosylationTWRTSTRNISSEEKT
EEEEECCCCCCCCEE		38.2814658030
424N-linked_GlycosylationTWEGNQVNITCEVFA
EECCCEEEEEEEEEE		17.6814658030
450N-linked_GlycosylationGQLLPSSNYSNIKIY
CCCCCCCCCCCEEEE		48.9019656770
453N-linked_GlycosylationLPSSNYSNIKIYNTP
CCCCCCCCEEEECCC		29.2519656770
479N-linked_GlycosylationENDFGNYNCTAVNRI
CCCCCCCCCCCEEEC		22.2114658030
554UbiquitinationHFKWYDAKEANMEGI
EEEEEEHHHHCCEEE		55.23-
589PhosphorylationGKGLGEISAATEFKT
CCCCCCCCEECCCCC		13.93-
684AcetylationENQQGKSKAAHFVFR
ECCCCCCCEEEEEEE		53.7522826441
706 (in isoform 3)GPI-anchor-34.75-
734PhosphorylationVVMDITCYFLNKCGL
HHHHHHHHHHHHCCH		11.4920605779
758UbiquitinationGKAGPGAKGKDMEEG
CCCCCCCCCCCHHHH		72.85-
766UbiquitinationGKDMEEGKAAFSKDE
CCCHHHHHCCCCCCC		39.56-
770PhosphorylationEEGKAAFSKDESKEP
HHHHCCCCCCCCCCC		34.1724925903
771UbiquitinationEGKAAFSKDESKEPI
HHHCCCCCCCCCCCC		60.09-
774PhosphorylationAAFSKDESKEPIVEV
CCCCCCCCCCCCEEE		53.0725521595
775UbiquitinationAFSKDESKEPIVEVR
CCCCCCCCCCCEEEE		66.51-
783PhosphorylationEPIVEVRTEEERTPN
CCCEEEECCCCCCCC		53.5824899341
788PhosphorylationVRTEEERTPNHDGGK
EECCCCCCCCCCCCC		31.5525521595
788 (in isoform 2)Phosphorylation-31.5529899451
797 (in isoform 2)Phosphorylation-57.5329899451
802 (in isoform 2)Phosphorylation-40.1130372032
802PhosphorylationKHTEPNETTPLTEPE
CCCCCCCCCCCCCCC		40.11-
803 (in isoform 2)Phosphorylation-15.3225521595
803PhosphorylationHTEPNETTPLTEPEL
CCCCCCCCCCCCCCC		15.32-
806 (in isoform 2)Phosphorylation-51.1825521595
815 (in isoform 2)Phosphorylation-22.3720415495
817 (in isoform 2)Phosphorylation-23.4926824392
882PhosphorylationATPSKGVTASSSSPA
CCCCCCCCCCCCCCC		29.50-
882O-linked_GlycosylationATPSKGVTASSSSPA
CCCCCCCCCCCCCCC		29.5055412801
884PhosphorylationPSKGVTASSSSPASA
CCCCCCCCCCCCCCC		22.7624925903
885PhosphorylationSKGVTASSSSPASAP
CCCCCCCCCCCCCCC		32.1624925903
886PhosphorylationKGVTASSSSPASAPK
CCCCCCCCCCCCCCC		37.5325521595
887PhosphorylationGVTASSSSPASAPKV
CCCCCCCCCCCCCCC		26.8325521595
890PhosphorylationASSSSPASAPKVAPL
CCCCCCCCCCCCCCC		48.7925521595
901PhosphorylationVAPLVDLSDTPTSAP
CCCCEECCCCCCCCC		34.6724925903
903PhosphorylationPLVDLSDTPTSAPSA
CCEECCCCCCCCCCH		25.7029899451
905PhosphorylationVDLSDTPTSAPSASN
EECCCCCCCCCCHHH		39.3424925903
906PhosphorylationDLSDTPTSAPSASNL
ECCCCCCCCCCHHHC		39.1124925903
909PhosphorylationDTPTSAPSASNLSST
CCCCCCCCHHHCCCE		44.0129899451
911PhosphorylationPTSAPSASNLSSTVL
CCCCCCHHHCCCEEE		42.5124925903
914PhosphorylationAPSASNLSSTVLANQ
CCCHHHCCCEEEECC		28.3724925903
915PhosphorylationPSASNLSSTVLANQG
CCHHHCCCEEEECCC		26.2124925903
916PhosphorylationSASNLSSTVLANQGA
CHHHCCCEEEECCCC		19.0324925903
926PhosphorylationANQGAVLSPSTPASA
ECCCCEECCCCCCCC		15.3725521595
928PhosphorylationQGAVLSPSTPASAGE
CCCEECCCCCCCCCC		43.5829899451
929PhosphorylationGAVLSPSTPASAGET
CCEECCCCCCCCCCC		26.6824925903
932PhosphorylationLSPSTPASAGETSKA
ECCCCCCCCCCCCCC		37.7024925903
936PhosphorylationTPASAGETSKAPPAS
CCCCCCCCCCCCCCH		34.3124925903
937PhosphorylationPASAGETSKAPPASK
CCCCCCCCCCCCCHH		23.6324925903
943PhosphorylationTSKAPPASKASPAPT
CCCCCCCHHCCCCCC		34.2330372032
946PhosphorylationAPPASKASPAPTPTP
CCCCHHCCCCCCCCC		25.9025521595
950PhosphorylationSKASPAPTPTPAGAA
HHCCCCCCCCCCCCC		41.7325521595
952PhosphorylationASPAPTPTPAGAASP
CCCCCCCCCCCCCCC		28.4025521595
958PhosphorylationPTPAGAASPLAAVAA
CCCCCCCCCHHHHCC		21.6625521595
968PhosphorylationAAVAAPATDAPQAKQ
HHHCCCCCCCCHHHH		31.4724925903
992PhosphorylationPEPTQPGTVKNPPEA
CCCCCCCCCCCCCHH		34.6821454597
1001PhosphorylationKNPPEAATAPASPKS
CCCCHHCCCCCCCCC		39.9825521595
1005PhosphorylationEAATAPASPKSKAAT
HHCCCCCCCCCCCCC		31.6225521595
1008PhosphorylationTAPASPKSKAATTNP
CCCCCCCCCCCCCCH		30.8021454597
1009MethylationAPASPKSKAATTNPS
CCCCCCCCCCCCCHH		48.44-
1012PhosphorylationSPKSKAATTNPSQGE
CCCCCCCCCCHHCCC		31.7828066266
1013PhosphorylationPKSKAATTNPSQGED
CCCCCCCCCHHCCCC		40.1728066266
1016PhosphorylationKAATTNPSQGEDLKM
CCCCCCHHCCCCCCC		53.5428066266
1030PhosphorylationMDEGNFKTPDIDLAK
CCCCCCCCCCCHHHH		23.2725521595
1053PhosphorylationPRPATGASGQASELA
CCCCCCCCCCHHHCC		32.55-
1082PhosphorylationTEKGPVETKSEPPES
CCCCCCCCCCCCCCC		39.8523684622
1083UbiquitinationEKGPVETKSEPPESE
CCCCCCCCCCCCCCC		39.0422790023
1084PhosphorylationKGPVETKSEPPESEA
CCCCCCCCCCCCCCC		63.8626824392
1099UbiquitinationKPAPTEVKTVPNDAT
CCCCCCCEECCCCCC		37.26-
1113PhosphorylationTQTKENESKA-----
CCCHHHHCCC-----		45.5215953420
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
734YPhosphorylationKinaseNTRK2Q63604
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NCAM1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NCAM1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
1433B_MOUSEYwhabphysical
20598904
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NCAM1_MOUSE

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-450, AND MASSSPECTROMETRY.
"The mouse C2C12 myoblast cell surface N-linked glycoproteome:identification, glycosite occupancy, and membrane orientation.";
Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I.,Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E.,Wollscheid B.;
Mol. Cell. Proteomics 8:2555-2569(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-450 AND ASN-453, AND MASSSPECTROMETRY.
"Identification of N-glycosylation sites of the murine neural celladhesion molecule NCAM by MALDI-TOF and MALDI-FTICR massspectrometry.";
Albach C., Damoc E., Denzinger T., Schachner M., Przybylski M.,Schmitz B.;
Anal. Bioanal. Chem. 378:1129-1135(2004).
Cited for: GLYCOSYLATION AT ASN-222; ASN-316; ASN-348; ASN-424; ASN-450 ANDASN-479, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774; SER-887; SER-946;THR-950; THR-952; SER-958 AND SER-1005, AND MASS SPECTROMETRY.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774, AND MASSSPECTROMETRY.
"Proteomic analysis of in vivo phosphorylated synaptic proteins.";
Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.;
J. Biol. Chem. 280:5972-5982(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774, AND MASSSPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887; SER-946; THR-950;SER-958 AND SER-1005, AND MASS SPECTROMETRY.

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