UB2V1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UB2V1_MOUSE
• UniProt AC: Q9CZY3
• Protein Name: Ubiquitin-conjugating enzyme E2 variant 1
• Gene Name: Ube2v1
• Organism: Mus musculus (Mouse).
• Sequence Length: 147
• Subcellular Localization: Nucleus. Excluded from the nucleolus..
• Protein Description: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation (By similarity). Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity)..
• Protein Sequence: MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPSVRFVTRVNMSGVSSSNGVVDPRATAVLAKWQNSHSIKVILQELRRLMMSKENMKLPQPPEGQCYSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATTGSGV ------CCCCCCCCC	17.32	-
4	Phosphorylation	----MAATTGSGVKV ----CCCCCCCCCCC	23.35	28066266
5	Phosphorylation	---MAATTGSGVKVP ---CCCCCCCCCCCC	25.32	28066266
7	Phosphorylation	-MAATTGSGVKVPRN -CCCCCCCCCCCCCC	38.02	30352176
10	Malonylation	ATTGSGVKVPRNFRL CCCCCCCCCCCCCHH	50.47	26320211
68	Ubiquitination	ENRIYSLKIECGPKY CCCEEEEEEECCCCC	30.44	-
68	Acetylation	ENRIYSLKIECGPKY CCCEEEEEEECCCCC	30.44	22826441
71	S-nitrosocysteine	IYSLKIECGPKYPEA EEEEEEECCCCCCCC	14.93	-
71	S-nitrosylation	IYSLKIECGPKYPEA EEEEEEECCCCCCCC	14.93	21278135
74	Ubiquitination	LKIECGPKYPEAPPS EEEECCCCCCCCCCC	59.74	-
74	Malonylation	LKIECGPKYPEAPPS EEEECCCCCCCCCCC	59.74	26320211
74	Acetylation	LKIECGPKYPEAPPS EEEECCCCCCCCCCC	59.74	23806337
110	Ubiquitination	RATAVLAKWQNSHSI HHHHHHHHHCCCHHH	45.19	-
118	Acetylation	WQNSHSIKVILQELR HCCCHHHHHHHHHHH	26.66	22826441
131	Ubiquitination	LRRLMMSKENMKLPQ HHHHHCCHHHCCCCC	34.90	-
131	Malonylation	LRRLMMSKENMKLPQ HHHHHCCHHHCCCCC	34.90	26320211
131	Acetylation	LRRLMMSKENMKLPQ HHHHHCCHHHCCCCC	34.90	22826441
135	Ubiquitination	MMSKENMKLPQPPEG HCCHHHCCCCCCCCC	69.47	-
144	S-nitrosocysteine	PQPPEGQCYSN---- CCCCCCCCCCC----	6.22	-
144	S-nitrosylation	PQPPEGQCYSN---- CCCCCCCCCCC----	6.22	21278135
145	Phosphorylation	QPPEGQCYSN----- CCCCCCCCCC-----	11.89	25619855
146	Phosphorylation	PPEGQCYSN------ CCCCCCCCC------	43.63	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UB2V1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UB2V1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UB2V1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE2N_MOUSE	Ube2n	physical	12039045
UBE2N_MOUSE	Ube2n	physical	11406273

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.