| UniProt ID | KCJ16_MOUSE | |
|---|---|---|
| UniProt AC | Q9Z307 | |
| Protein Name | Inward rectifier potassium channel 16 | |
| Gene Name | Kcnj16 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 419 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . Basolateral cell membrane . In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. |
|
| Protein Description | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.. | |
| Protein Sequence | MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSIFWLIAFHHGDLLSDPDITPCVDNVHSFTAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYIPREILWGHRFHDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLNNLEKTSPARGSCNSDTNTRRRSFSAVAVVSSCENPEETVLSPQDECKEMPYQKALLTLNRISMESQM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MSYYGSSYRIVNV --CCCCCCCEEEEEC | 20139300 | ||
| 15 | Phosphorylation | YRIVNVDSKYPGYPP EEEEECCCCCCCCCC | 22418434 | ||
| 16 | Ubiquitination | RIVNVDSKYPGYPPE EEEECCCCCCCCCCH | 27667366 | ||
| 347 | Ubiquitination | SAKQLDWKDQQLNNL CHHHCCCCHHHHHCC | 27667366 | ||
| 356 | Ubiquitination | QQLNNLEKTSPARGS HHHHCCCCCCCCCCC | - | ||
| 358 | Phosphorylation | LNNLEKTSPARGSCN HHCCCCCCCCCCCCC | 22817900 | ||
| 363 | Phosphorylation | KTSPARGSCNSDTNT CCCCCCCCCCCCCCC | 29899451 | ||
| 366 | Phosphorylation | PARGSCNSDTNTRRR CCCCCCCCCCCCCCC | 29899451 | ||
| 374 | Phosphorylation | DTNTRRRSFSAVAVV CCCCCCCCEEEEEEE | 25521595 | ||
| 376 | Phosphorylation | NTRRRSFSAVAVVSS CCCCCCEEEEEEEEC | 25521595 | ||
| 405 | Ubiquitination | CKEMPYQKALLTLNR HHCCHHHHHHHHHHH | - | ||
| 414 | Phosphorylation | LLTLNRISMESQM-- HHHHHHHHHHHCC-- | 21183079 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCJ16_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCJ16_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCJ16_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of KCJ16_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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