AGRB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRB3_MOUSE
• UniProt AC: Q80ZF8
• Protein Name: Adhesion G protein-coupled receptor B3
• Gene Name: Adgrb3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1522
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. [PubMed: 23628982 Promotes myoblast fusion through ELMO/DOCK1 (By similarity]
• Protein Sequence: MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSVSEMFPKNFTNCTWTLENPDPTKYSIYLKFSKKDLSCSNFSLLAYQFDHFSHEKIKDLLRKNHSIMQLCSSKNAFVFLQYDKNFIQIRRVFPTDFPGLQKKVEEDQKSFFEFLVLNKVSPSQFGCHVLCTWLESCLKSENGRTESCGIMYTKCTCPQHLGEWGIDDQSLVLLNNVVLPLNEQTEGCLTQELQTTQVCNLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESGVEEWSQWSACSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALCPVDGQWQEWSSWSHCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSKSCDGGWERRMRTCQGAAVTGQQCEGTGEEVRRCSEQRCPAPYEICPEDYLISMVWKRTPAGDLAFNQCPLNATGTTSRRCSLSLHGVASWEQPSFARCISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTKTLLDLTQRKNFYAGDLLVSVEILRNVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEKWEDAQQIYPGSIELMQVIEDFIHIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINFPMKGRKGMVDWARNSEDRVVIPKSIFTPVSSKELDESSVFVLGAVLYKNLDLILPTLRNYTVVNSKVIVVTIRPEPKTTDSFLEIELAHLANGTLNPYCVLWDDSKSNESLGTWSTQGCKTVLTDASHTKCLCDRLSTFAILAQQPREIVMESSGTPSVTLIVGSGLSCLALITLAVVYAALWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVLTEAWQSYMAVTGKIRTRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVLHKDIGPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPMSMNELSNPCLKKENTELRRTVYLCTDDNLRGADMDIVHPQERMMESDYIVMPRSSVSTQPSMKEESKMNIGMETLPHERLLHYKVNPEFNMNPPVMDQFNMNLDQHLAPQEHMQNLPFEPRTAVKNFMASELDDNVGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHMELFQELNQKFQTLDRFRDIPNTSSMENPAPNKNPWDTFKPPSEYQHYTTINVLDTEAKDTLELRPAEWEKCLNLPLDVQEGDFQTEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	VSEMFPKNFTNCTWT HHHHCCCCCCCCEEE		-
54	N-linked_Glycosylation	MFPKNFTNCTWTLEN HCCCCCCCCEEEECC		-
82	N-linked_Glycosylation	KKDLSCSNFSLLAYQ CCCCCCCCCHHHHHH		-
105	N-linked_Glycosylation	IKDLLRKNHSIMQLC HHHHHHHCCCHHHHH		-
241	N-linked_Glycosylation	LQTTQVCNLTREAKR HHHHHHHHCCCCCCC		-
337	N-linked_Glycosylation	LRESRVCNNTALCPV CCCCCCCCCCCCCCC		-
418	N-linked_Glycosylation	HCSVTCSNGTQQRSR CCEEECCCCCCHHEE		-
540	N-linked_Glycosylation	AFNQCPLNATGTTSR ECCCCCCCCCCCCCC		-
619	Phosphorylation	YAGDLLVSVEILRNV CCCCCEEEHHHHHHC		-
625	N-linked_Glycosylation	VSVEILRNVTDTFKR EEHHHHHHCCHHHHH		-
726	Acetylation	NFPMKGRKGMVDWAR CCCCCCCCCCCHHHC		6569287
750	Phosphorylation	KSIFTPVSSKELDES HHHCCCCCCCCCCCC		22324799
751	Phosphorylation	SIFTPVSSKELDESS HHCCCCCCCCCCCCH		25521595
779	N-linked_Glycosylation	LILPTLRNYTVVNSK CHHHHCCCCEEECCE		-
781	Phosphorylation	LPTLRNYTVVNSKVI HHHCCCCEEECCEEE		21454597
785	Phosphorylation	RNYTVVNSKVIVVTI CCCEEECCEEEEEEE		21454597
791	Phosphorylation	NSKVIVVTIRPEPKT CCEEEEEEEECCCCC		21454597
812	N-linked_Glycosylation	IELAHLANGTLNPYC HHHHHHHCCCCCCCE		-
828	N-linked_Glycosylation	LWDDSKSNESLGTWS EECCCCCCCCCCCCC		-
937	N-linked_Glycosylation	VGQTQTHNKSICTTT ECCCCCCCCCCCHHH		-
1115	Phosphorylation	LLALTWMSAVLAMTD HHHHHHHHHHHHHCC		26026062
1121	Phosphorylation	MSAVLAMTDKRSILF HHHHHHHCCHHHHHH		26026062
1213	Phosphorylation	PCRAATITGTLSRIS CCCCCEEEEEEEEEE		29899451
1217	Phosphorylation	ATITGTLSRISLNDD CEEEEEEEEEECCCC		29899451
1220	Phosphorylation	TGTLSRISLNDDEEE EEEEEEEECCCCCCC		25521595
1230	Phosphorylation	DDEEEKGTNPEGLSY CCCCCCCCCCCCCCC		22807455
1236	Phosphorylation	GTNPEGLSYSTLPGN CCCCCCCCCCCCCCC		29899451
1239	Phosphorylation	PEGLSYSTLPGNVIS CCCCCCCCCCCCEEE		29899451
1308	Phosphorylation	ERMMESDYIVMPRSS HHHHCCCEEEECCCC		29899451
1315	Phosphorylation	YIVMPRSSVSTQPSM EEEECCCCCCCCCCC		29899451
1385	Ubiquitination	FEPRTAVKNFMASEL CCCHHHHHHHHHHHC		22790023
1385	Ubiquitination	FEPRTAVKNFMASEL CCCHHHHHHHHHHHC		22790023
1399	Phosphorylation	LDDNVGLSRSETGST CCCCCCCCCCCCCCC		29899451
1399	O-linked_Glycosylation	LDDNVGLSRSETGST CCCCCCCCCCCCCCC		55411097
1401	Phosphorylation	DNVGLSRSETGSTIS CCCCCCCCCCCCCCC		24925903
1403	Phosphorylation	VGLSRSETGSTISMS CCCCCCCCCCCCCHH		24925903
1405	Phosphorylation	LSRSETGSTISMSSL CCCCCCCCCCCHHHH		24925903
1406	Phosphorylation	SRSETGSTISMSSLE CCCCCCCCCCHHHHH		22324799
1408	Phosphorylation	SETGSTISMSSLERR CCCCCCCCHHHHHHH		22324799
1410	Phosphorylation	TGSTISMSSLERRKS CCCCCCHHHHHHHHH		22324799
1411	Phosphorylation	GSTISMSSLERRKSR CCCCCHHHHHHHHHH		25521595
1419	Phosphorylation	LERRKSRYSDLDFEK HHHHHHHCCCCCHHH		29899451
1420	Phosphorylation	ERRKSRYSDLDFEKV HHHHHHCCCCCHHHH		29899451
1459	Phosphorylation	RDIPNTSSMENPAPN CCCCCCCCCCCCCCC		29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRB3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRB3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRB3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AGRB3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.