ADA22_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADA22_MOUSE
• UniProt AC: Q9R1V6
• Protein Name: Disintegrin and metalloproteinase domain-containing protein 22
• Gene Name: Adam22
• Organism: Mus musculus (Mouse).
• Sequence Length: 904
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Cell projection, axon .
• Protein Description: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1..
• Protein Sequence: MQAAAAASFWLLCVLGTCPLARCGRAGVASLKGLERGKENRFLERQSIIPLRLIYRLGGEDETQHNQLDTRVRGDPGGPQLTHVDKASFRVDAFGTSFVLDVLLNHELLSSGYVERQIEHGGKVVENKGGEHCYYQGQIRGNPVSFVALSTCHGLHGMFYDGNHTYLIEPEENEKSQESSHCHSVYKSRQFEFPLDDLPSEFQRVNITPPQFILKPRLKRRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKDQLKTRIVLVAMETWAADNKFAISENPLITLREFMKYRRDFIKEKADAVHLFSGSQFESSRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNVGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNVEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCDIREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGAHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCSSSKAGTVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDFPPGGSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNMGGNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	S-nitrosylation	GTCPLARCGRAGVAS CCCCHHHCCCCHHHH	3.44	21278135
23	S-nitrosocysteine	GTCPLARCGRAGVAS CCCCHHHCCCCHHHH	3.44	-
163	N-linked_Glycosylation	HGMFYDGNHTYLIEP EEEEECCCEEEEECC	22.79	-
367	Phosphorylation	KTDLMAVTLAQSLAH CCHHHHHHHHHHHHH	13.56	20047950
387	Phosphorylation	SDKRKLASGECKCED CCCCHHHCCCCCCCC	45.63	20415495
517	N-linked_Glycosylation	IREICSGNSSQCAPN HHHHCCCCCCCCCCC	23.38	-
632	N-linked_Glycosylation	VQQGRTLNCSGAHVK EECCCEEECCCCEEE	19.80	-
673	N-linked_Glycosylation	CLPVASFNFSTCSSS EEEEEEEECCCCCCC	27.71	-
772	Phosphorylation	RQLPQGDYVKKPGDG HCCCCCCCCCCCCCC	22.46	29514104
781	Phosphorylation	KKPGDGDSFYSDFPP CCCCCCCCCCCCCCC	31.45	25521595
783	Phosphorylation	PGDGDSFYSDFPPGG CCCCCCCCCCCCCCC	15.98	25521595
784	Phosphorylation	GDGDSFYSDFPPGGS CCCCCCCCCCCCCCC	30.66	22807455
798	Phosphorylation	STNSASSSKKRSNGL CCCCCCCCCCCCCCC	39.44	51458265
802	Phosphorylation	ASSSKKRSNGLSHSW CCCCCCCCCCCCCCH	44.09	21183079
806	Phosphorylation	KKRSNGLSHSWSERI CCCCCCCCCCHHHCC	19.51	22324799
808	Phosphorylation	RSNGLSHSWSERIPD CCCCCCCCHHHCCCC	28.99	22324799
810	Phosphorylation	NGLSHSWSERIPDTK CCCCCCHHHCCCCCC	21.73	22324799
814 (in isoform 6)	Phosphorylation	-	49.82	20047950
816	Phosphorylation	WSERIPDTKHISDIC HHHCCCCCCCHHHHH	21.11	22324799
817 (in isoform 10)	Phosphorylation	-	46.45	25521595
817 (in isoform 17)	Phosphorylation	-	46.45	29899451
817 (in isoform 11)	Ubiquitination	-	46.45	22790023
817	Ubiquitination	SERIPDTKHISDICE HHCCCCCCCHHHHHH	46.45	22790023
819 (in isoform 17)	Phosphorylation	-	4.16	29899451
819 (in isoform 10)	Phosphorylation	-	4.16	25521595
820 (in isoform 17)	Phosphorylation	-	22.20	29899451
820 (in isoform 7)	Phosphorylation	-	22.20	20047950
820 (in isoform 10)	Phosphorylation	-	22.20	25521595
820	Phosphorylation	IPDTKHISDICENGR CCCCCCHHHHHHCCC	22.20	22324799
822 (in isoform 10)	Phosphorylation	-	2.24	20415495
830	Phosphorylation	CENGRPRSNSWQGNM HHCCCCCCCCCCCCC	37.59	25521595
832	Phosphorylation	NGRPRSNSWQGNMGG CCCCCCCCCCCCCCC	23.25	25521595
853	Phosphorylation	GKRFRPRSNSTETLS CCCCCCCCCCCCCCC	37.50	22324799
855	Phosphorylation	RFRPRSNSTETLSPA CCCCCCCCCCCCCCC	28.94	25521595
856	Phosphorylation	FRPRSNSTETLSPAK CCCCCCCCCCCCCCC	36.92	25521595
856 (in isoform 8)	Phosphorylation	-	36.92	20047950
858	Phosphorylation	PRSNSTETLSPAKSP CCCCCCCCCCCCCCC	32.40	22324799
860	Phosphorylation	SNSTETLSPAKSPSS CCCCCCCCCCCCCCC	30.17	25521595
864	Phosphorylation	ETLSPAKSPSSSTGS CCCCCCCCCCCCCCC	31.92	25521595
866	Phosphorylation	LSPAKSPSSSTGSIA CCCCCCCCCCCCCCC	43.97	25521595
867	Phosphorylation	SPAKSPSSSTGSIAS CCCCCCCCCCCCCCC	34.99	22324799
868	Phosphorylation	PAKSPSSSTGSIASS CCCCCCCCCCCCCCC	40.92	25521595
869	Phosphorylation	AKSPSSSTGSIASSR CCCCCCCCCCCCCCC	36.58	22324799
871	Phosphorylation	SPSSSTGSIASSRKY CCCCCCCCCCCCCCC	18.31	25521595
874	Phosphorylation	SSTGSIASSRKYPYP CCCCCCCCCCCCCCC	29.07	22324799
875	Phosphorylation	STGSIASSRKYPYPM CCCCCCCCCCCCCCC	24.62	22324799
882 (in isoform 14)	Phosphorylation	-	4.38	25521595
884 (in isoform 14)	Phosphorylation	-	50.72	25521595
885 (in isoform 14)	Phosphorylation	-	7.42	25521595
887 (in isoform 14)	Phosphorylation	-	82.21	20415495
918 (in isoform 14)	Phosphorylation	-		21183079
926 (in isoform 11)	Phosphorylation	-		21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADA22_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADA22_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADA22_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ADA22_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832; SER-864 ANDSER-866, AND MASS SPECTROMETRY.
PubMed: 17114649