dbPTM

GRIN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRIN1_MOUSE
UniProt AC	Q3UNH4
Protein Name	G protein-regulated inducer of neurite outgrowth 1
Gene Name	Gprin1
Organism	Mus musculus (Mouse).
Sequence Length	932
Subcellular Localization	Cell membrane Lipid-anchor. Cell projection, growth cone. Highly enriched in growth cone.
Protein Description	May be involved in neurite outgrowth..
Protein Sequence	MRDCCSSPKAIPAPPRHALDQSLGMDPRHTSSSGAAEGASCSERPAGSLACPSPNCSPLPETPRAHGALTSDNSGTTLFGKPEPMSSAEATPTASEIRNPVFSGKMDGNSLKQADSTSTRKEEAGSLRNEESMLKGKAEPMIYGKGEPGTVGRVDCTASGAENSGSLGKVDMPCSSKVDIVSPGGDNAGSLRKVETISSGKMDPKTENVMHSRRERPGSTGEGDLVSLRENDMKPPDNTDSASTKKTDPEFSGKLTPGSSGKTELVSSVTVAPVTSENVNPVCSGGAGPAAVGNSETLSSVKKDPQLLGKKEAVSSGEGGSVSVRMAETVSARQPEGMFPAKTDSTSSNSTGPSGRADPVSLRNSELVSPVKPERLSSGQAERVSLVKTETLSSGKEDPRSSRRVDHTTVTGNMQTSQKGNPESSGKTDLGSSSSGDTRSLGTWGSLSAAKAEVTEGKGDPQPWKKASLPASEKTDPLASSKAGSASQGKAETVSPGEVDAMTLGKTVPTSSGKTALVSPGKVDLMTSERAEGIPELQASEKGNPVNSTRVDTGATGSTEPKSGVKVITQIPGATSPGKVETPSLQKEQPQLSEKTDPSRKVDPPTTVEPVSLGKADSASPSPRKAESQTSAKTVPQAPDKATSSLRQSDGTPYSSAQPQRDTRSIGSLPEREPSASTSQKDLAAAAAQKSPSAEAAAPPPGPRTRDNFTKAPSWDAGAPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGPAFSFQAAPRAPSPAPRPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAVPPVFPEVRVRPGSVLAAALAPQEATEPVRDVSWDEKGMTWEVYGASMEVEVLGMAIQKHLERQIEEHGRQGAPAPAPPPAVRAGPGRAGSVRTAPAEGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRDCCSSPKAIPA --CCCCCCCCCCCCC	56.88	29899451
22	Phosphorylation	PRHALDQSLGMDPRH CCCHHHHHCCCCCCC	26.93	-
33	Phosphorylation	DPRHTSSSGAAEGAS CCCCCCCCCCCCCCC	32.02	-
42	Phosphorylation	AAEGASCSERPAGSL CCCCCCCCCCCCCCC	33.86	29899451
53	Phosphorylation	AGSLACPSPNCSPLP CCCCCCCCCCCCCCC	28.73	29899451
57	Phosphorylation	ACPSPNCSPLPETPR CCCCCCCCCCCCCCC	35.79	29899451
62	Phosphorylation	NCSPLPETPRAHGAL CCCCCCCCCCCCCCC	19.01	-
164	Phosphorylation	TASGAENSGSLGKVD CCCCCCCCCCCCCCC	22.67	29899451
166	Phosphorylation	SGAENSGSLGKVDMP CCCCCCCCCCCCCCC	33.50	25521595
175	Phosphorylation	GKVDMPCSSKVDIVS CCCCCCCCCCEEEEC	27.59	29899451
182	Phosphorylation	SSKVDIVSPGGDNAG CCCEEEECCCCCCCC	20.40	25521595
190	Phosphorylation	PGGDNAGSLRKVETI CCCCCCCCCEEEEEE	23.69	25521595
196	Phosphorylation	GSLRKVETISSGKMD CCCEEEEEECCCCCC	29.19	-
198	Phosphorylation	LRKVETISSGKMDPK CEEEEEECCCCCCCC	40.22	29899451
199	Phosphorylation	RKVETISSGKMDPKT EEEEEECCCCCCCCC	38.28	23684622
206	Phosphorylation	SGKMDPKTENVMHSR CCCCCCCCCCCCCCC	37.87	23684622
212	Phosphorylation	KTENVMHSRRERPGS CCCCCCCCCCCCCCC	18.22	29899451
219	Phosphorylation	SRRERPGSTGEGDLV CCCCCCCCCCCCCEE	35.60	25521595
220	Phosphorylation	RRERPGSTGEGDLVS CCCCCCCCCCCCEEE	45.21	24925903
227	Phosphorylation	TGEGDLVSLRENDMK CCCCCEEECCCCCCC	29.07	24925903
256	Phosphorylation	PEFSGKLTPGSSGKT HHHCCCCCCCCCCCE	29.14	30372032
316	Phosphorylation	GKKEAVSSGEGGSVS CCCEEECCCCCCCEE	33.97	29899451
343	O-linked_Glycosylation	EGMFPAKTDSTSSNS CCCCCCCCCCCCCCC	36.97	55412153
347	Phosphorylation	PAKTDSTSSNSTGPS CCCCCCCCCCCCCCC	31.32	29899451
348	Phosphorylation	AKTDSTSSNSTGPSG CCCCCCCCCCCCCCC	34.58	29899451
365	Phosphorylation	DPVSLRNSELVSPVK CCCCCCCCCCCCCCC	26.35	20415495
369	Phosphorylation	LRNSELVSPVKPERL CCCCCCCCCCCHHHC	36.28	25521595
377	Phosphorylation	PVKPERLSSGQAERV CCCHHHCCCCCCEEE	38.35	27841257
378	Phosphorylation	VKPERLSSGQAERVS CCHHHCCCCCCEEEE	39.24	27841257
393	Phosphorylation	LVKTETLSSGKEDPR EEEEEECCCCCCCCC	44.45	27841257
394	Phosphorylation	VKTETLSSGKEDPRS EEEEECCCCCCCCCC	57.93	27841257
411	Phosphorylation	RVDHTTVTGNMQTSQ CCEEEEEECCCCCCC	22.27	29899451
416	Phosphorylation	TVTGNMQTSQKGNPE EEECCCCCCCCCCCC	23.51	29899451
417	Phosphorylation	VTGNMQTSQKGNPES EECCCCCCCCCCCCC	17.01	27841257
432	Phosphorylation	SGKTDLGSSSSGDTR CCCCCCCCCCCCCCC	34.05	29899451
433	Phosphorylation	GKTDLGSSSSGDTRS CCCCCCCCCCCCCCC	27.07	29899451
435	Phosphorylation	TDLGSSSSGDTRSLG CCCCCCCCCCCCCCC	42.51	27841257
443	Phosphorylation	GDTRSLGTWGSLSAA CCCCCCCCCCCHHHH	31.76	22324799
446	Phosphorylation	RSLGTWGSLSAAKAE CCCCCCCCHHHHEEE	15.65	25521595
448	Phosphorylation	LGTWGSLSAAKAEVT CCCCCCHHHHEEEEC	28.07	25521595
468	Phosphorylation	PQPWKKASLPASEKT CCCCHHCCCCCCCCC	43.71	22817900
493	Phosphorylation	ASQGKAETVSPGEVD CCCCCCEECCCCCCC	31.01	24925903
495	Phosphorylation	QGKAETVSPGEVDAM CCCCEECCCCCCCEE	34.31	25521595
515	Phosphorylation	VPTSSGKTALVSPGK EECCCCCEEEECCCE	28.84	25177544
519	Phosphorylation	SGKTALVSPGKVDLM CCCEEEECCCEEEEC	28.87	25521595
540	Phosphorylation	GIPELQASEKGNPVN CCCCCCHHCCCCCCC	27.21	29899451
569	Phosphorylation	KSGVKVITQIPGATS CCCCEEEEECCCCCC	24.35	30372032
575	Phosphorylation	ITQIPGATSPGKVET EEECCCCCCCCCCCC	41.17	25521595
576	Phosphorylation	TQIPGATSPGKVETP EECCCCCCCCCCCCC	30.99	25521595
582	Phosphorylation	TSPGKVETPSLQKEQ CCCCCCCCCCCCCCC	22.59	24925903
584	Phosphorylation	PGKVETPSLQKEQPQ CCCCCCCCCCCCCCC	51.34	29899451
606	Phosphorylation	SRKVDPPTTVEPVSL CCCCCCCCCCCCCCC	49.19	-
607	Phosphorylation	RKVDPPTTVEPVSLG CCCCCCCCCCCCCCC	28.75	29899451
612	Phosphorylation	PTTVEPVSLGKADSA CCCCCCCCCCCCCCC	41.96	22807455
618	Phosphorylation	VSLGKADSASPSPRK CCCCCCCCCCCCCCC	35.19	28382018
620	Phosphorylation	LGKADSASPSPRKAE CCCCCCCCCCCCCCC	29.84	25521595
622	Phosphorylation	KADSASPSPRKAESQ CCCCCCCCCCCCCCC	34.54	25521595
645	Phosphorylation	APDKATSSLRQSDGT CCCCHHHHHCCCCCC	24.18	29899451
649	Phosphorylation	ATSSLRQSDGTPYSS HHHHHCCCCCCCCCC	31.41	29899451
652	Phosphorylation	SLRQSDGTPYSSAQP HHCCCCCCCCCCCCC	24.84	29899451
654	Phosphorylation	RQSDGTPYSSAQPQR CCCCCCCCCCCCCCC	18.33	29899451
656	Phosphorylation	SDGTPYSSAQPQRDT CCCCCCCCCCCCCCC	25.69	29899451
665	Phosphorylation	QPQRDTRSIGSLPER CCCCCCCCCCCCCCC	33.13	28066266
668	Phosphorylation	RDTRSIGSLPEREPS CCCCCCCCCCCCCCC	38.80	27841257
675	Phosphorylation	SLPEREPSASTSQKD CCCCCCCCCCCCHHH	30.05	21183079
677	Phosphorylation	PEREPSASTSQKDLA CCCCCCCCCCHHHHH	32.69	30372032
678	Phosphorylation	EREPSASTSQKDLAA CCCCCCCCCHHHHHH	34.59	25521595
679	Phosphorylation	REPSASTSQKDLAAA CCCCCCCCHHHHHHH	32.51	30372032
691	Phosphorylation	AAAAAQKSPSAEAAA HHHHHHHCCCHHHCC	16.41	25521595
693	Phosphorylation	AAAQKSPSAEAAAPP HHHHHCCCHHHCCCC	45.92	25521595
714	Phosphorylation	DNFTKAPSWDAGAPP CCCCCCCCCCCCCCC	42.31	25521595
728	Phosphorylation	PPREDAGTQAGAQAC CCCHHCCCHHHHCEE	19.57	20415495
737	Phosphorylation	AGAQACVSVAVSPMS HHHCEEEEEEECCCC	12.30	20415495
741	Phosphorylation	ACVSVAVSPMSPQDG EEEEEEECCCCCCCC	12.73	20415495
744	Phosphorylation	SVAVSPMSPQDGAGG EEEECCCCCCCCCCC	23.85	20415495
755	Phosphorylation	GAGGPAFSFQAAPRA CCCCCCCCCCCCCCC	20.68	20415495
764	Phosphorylation	QAAPRAPSPAPRPPS CCCCCCCCCCCCCCC	32.48	25521595
771	Phosphorylation	SPAPRPPSRRDAGLQ CCCCCCCCHHCCCCE	42.50	25521595
780	Phosphorylation	RDAGLQVSLGAAETR HCCCCEEEECCCCCC	14.23	22817900
786	Phosphorylation	VSLGAAETRSVATGP EEECCCCCCCCCCCC	24.42	22817900
788	Phosphorylation	LGAAETRSVATGPMT ECCCCCCCCCCCCCC	24.43	24925903
791	Phosphorylation	AETRSVATGPMTPQA CCCCCCCCCCCCCCC	39.40	24925903
795	Phosphorylation	SVATGPMTPQAAAPP CCCCCCCCCCCCCCC	18.51	25521595
817	Phosphorylation	EVRVRPGSVLAAALA CCEECCCCHHHHHHC	19.35	22817900
836	Phosphorylation	TEPVRDVSWDEKGMT CCCCCCCCCCCCCCE	32.85	22817900
894	Phosphorylation	AGPGRAGSVRTAPAE CCCCCCCCCCCCCCC	13.87	29899451
905	Ubiquitination	APAEGAAKRPPGLFR CCCCCHHHCCCCHHH	65.97	22790023
917	Phosphorylation	LFRALLQSVRRPRCC HHHHHHHHHCCCCHH	19.98	22817900
923	S-palmitoylation	QSVRRPRCCSRAGPT HHHCCCCHHCCCCCC	2.47	15585744
924	S-palmitoylation	SVRRPRCCSRAGPTA HHCCCCHHCCCCCCC	3.05	15585744

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GRIN1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
923	C	Palmitoylation	15585744
Palmitoylation on Cys-923 and/or Cys-924 is required for membrane targeting.
924	C	Palmitoylation	15585744
Palmitoylation on Cys-923 and/or Cys-924 is required for membrane targeting.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRIN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GRIN1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GRIN1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182; SER-190; SER-495;THR-575; SER-691; SER-693; SER-714 AND THR-795, AND MASS SPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-795, AND MASSSPECTROMETRY.	16452087 [Abstract]

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