CACB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACB2_MOUSE
• UniProt AC: Q8CC27
• Protein Name: Voltage-dependent L-type calcium channel subunit beta-2
• Gene Name: Cacnb2
• Organism: Mus musculus (Mouse).
• Sequence Length: 655
• Subcellular Localization: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting..
• Protein Sequence: MVQSDTSKSPPVAAVAQESQMELLESAAPAGALGAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVRYSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPQESFDVILDENQLEDACEHLADYLEAYWKATHPPSGNLPNPLLSRTLASSTLPLSPTLASNSQGSQGDQRPDRSAPRSASQAEEEPCLEPVKKSQHRSSSATHQNHRSGTGRGLSRQETFDSETQESRDSAYVEPKEDYSHEHVDRYVPHREHNHREETHSSNGHRHRESRHRSRDMGRDQDHNECIKQRSRHKSKDRYCDKEGEVISKRRNEAGEWNRDVYIRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	SQMELLESAAPAGAL HHHHHHHHHCCHHHH	29.69	29109428
37	Phosphorylation	AGALGAQSYGKGARR HHHHCHHHCCCCCCC	35.01	29109428
54	Phosphorylation	RFKGSDGSTSSDTTS CCCCCCCCCCCCCCC	30.06	24899341
55	Phosphorylation	FKGSDGSTSSDTTSN CCCCCCCCCCCCCCC	37.47	29899451
57	Phosphorylation	GSDGSTSSDTTSNSF CCCCCCCCCCCCCCC	38.78	24899341
59	Phosphorylation	DGSTSSDTTSNSFVR CCCCCCCCCCCCCCC	33.79	29899451
63	Phosphorylation	SSDTTSNSFVRQGSA CCCCCCCCCCCCCCC	25.53	19060867
69	Phosphorylation	NSFVRQGSADSYTSR CCCCCCCCCCCCCCC	22.14	27841257
73	Phosphorylation	RQGSADSYTSRPSDS CCCCCCCCCCCCCCC	14.85	-
78	Phosphorylation	DSYTSRPSDSDVSLE CCCCCCCCCCCCCHH	48.95	19060867
80	Phosphorylation	YTSRPSDSDVSLEED CCCCCCCCCCCHHHH	44.22	21183079
83	Phosphorylation	RPSDSDVSLEEDREA CCCCCCCCHHHHHHH	34.75	22817900
196	Phosphorylation	GKFYSSKSGGNSSSS CCCCCCCCCCCCCCC	54.61	23737553
200	Phosphorylation	SSKSGGNSSSSLGDI CCCCCCCCCCCCCCC	34.57	23737553
201	Phosphorylation	SKSGGNSSSSLGDIV CCCCCCCCCCCCCCC	28.13	23737553
202	Phosphorylation	KSGGNSSSSLGDIVP CCCCCCCCCCCCCCC	29.42	23737553
203	Phosphorylation	SGGNSSSSLGDIVPS CCCCCCCCCCCCCCC	38.02	25521595
210	Phosphorylation	SLGDIVPSSRKSTPP CCCCCCCCCCCCCCC	31.70	29899451
211	Phosphorylation	LGDIVPSSRKSTPPS CCCCCCCCCCCCCCC	37.34	22817900
214	Phosphorylation	IVPSSRKSTPPSSAI CCCCCCCCCCCCCCC	45.06	27742792
215	Phosphorylation	VPSSRKSTPPSSAID CCCCCCCCCCCCCCE	42.10	25521595
218	Phosphorylation	SRKSTPPSSAIDIDA CCCCCCCCCCCEECC	33.34	23737553
219	Phosphorylation	RKSTPPSSAIDIDAT CCCCCCCCCCEECCC	34.71	23737553
226	Phosphorylation	SAIDIDATGLDAEEN CCCEECCCCCCHHHC	34.23	27742792
250	Phosphorylation	KPSANSVTSPHSKEK CCCCCCCCCCCCCCC	36.04	29899451
251	Phosphorylation	PSANSVTSPHSKEKR CCCCCCCCCCCCCCC	20.61	29899451
286	Phosphorylation	PVVLVGPSLKGYEVT CEEEECCCCCCCCHH	36.46	-
341	Phosphorylation	KHAIIERSNTRSSLA CCEEEECCCCCHHHH	29.75	29899451
343	Phosphorylation	AIIERSNTRSSLAEV EEEECCCCCHHHHHH	32.92	21082442
346	Phosphorylation	ERSNTRSSLAEVQSE ECCCCCHHHHHHHHH	28.45	25521595
479	Phosphorylation	LLSRTLASSTLPLSP HHHHHHHCCCCCCCC	27.28	23737553
480	Phosphorylation	LSRTLASSTLPLSPT HHHHHHCCCCCCCCC	28.49	23737553
481	Phosphorylation	SRTLASSTLPLSPTL HHHHHCCCCCCCCCC	29.87	23737553
485	Phosphorylation	ASSTLPLSPTLASNS HCCCCCCCCCCCCCC	17.56	26745281
487	Phosphorylation	STLPLSPTLASNSQG CCCCCCCCCCCCCCC	31.42	27742792
490	Phosphorylation	PLSPTLASNSQGSQG CCCCCCCCCCCCCCC	39.88	27742792
492	Phosphorylation	SPTLASNSQGSQGDQ CCCCCCCCCCCCCCC	33.16	26745281
495	Phosphorylation	LASNSQGSQGDQRPD CCCCCCCCCCCCCCC	24.29	27742792
508	Phosphorylation	PDRSAPRSASQAEEE CCCCCCCCHHHCCCC	31.08	25521595
510	Phosphorylation	RSAPRSASQAEEEPC CCCCCCHHHCCCCCC	31.04	25521595
529	Phosphorylation	KKSQHRSSSATHQNH CCCCCCCCCCCCCCC	24.77	22589548
530	Phosphorylation	KSQHRSSSATHQNHR CCCCCCCCCCCCCCC	38.13	27841257
545	Phosphorylation	SGTGRGLSRQETFDS CCCCCCCCCCCCCCC	34.44	22817900
549	Phosphorylation	RGLSRQETFDSETQE CCCCCCCCCCCCCHH	25.14	25521595
552	Phosphorylation	SRQETFDSETQESRD CCCCCCCCCCHHHHH	38.05	25521595
554	Phosphorylation	QETFDSETQESRDSA CCCCCCCCHHHHHCC	41.40	23737553
625	Phosphorylation	KQRSRHKSKDRYCDK HHHHHHCCCCCCCCC	33.39	22589548

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CACB2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
549	T	Phosphorylation	Regulated through phosphorylation at Thr-549 by CaMK2D.	21183079

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAC1A_MOUSE	Cacna1a	physical	16787652
CAC1B_MOUSE	Cacna1b	physical	16787652

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.