CAC1A_MOUSE - dbPTM
CAC1A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAC1A_MOUSE
UniProt AC P97445
Protein Name Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Gene Name Cacna1a
Organism Mus musculus (Mouse).
Sequence Length 2368
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA)..
Protein Sequence MARFGDEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYGDAAERWPTPYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHEGGMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPLVSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDWC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
38PhosphorylationGGRGAGGSRQGGQPG
CCCCCCCCCCCCCCH		22.1029899451
39MethylationGRGAGGSRQGGQPGA
CCCCCCCCCCCCCHH		42.30-
53PhosphorylationAQRMYKQSMAQRART
HHHHHHHHHHHHHHH		16.37-
73S-palmitoylationPIPVRQNCLTVNRSL
CCCCCCCCEEECCHH		2.2628680068
285N-linked_GlycosylationEPARTCPNGTKCQPY
CCCCCCCCCCCCCCC		73.28-
411PhosphorylationVILAEDETDVEQRHP
EEECCCCCCHHHHCC		58.6325521595
427PhosphorylationDGALRRATLKKSKTD
CHHHHHHHHCCCHHC		36.98-
431PhosphorylationRRATLKKSKTDLLNP
HHHHHCCCHHCCCCH		38.9219060867
433PhosphorylationATLKKSKTDLLNPEE
HHHCCCHHCCCCHHH		38.6819060867
450PhosphorylationDQLADIASVGSPFAR
HHHHHHHHCCCHHHH		27.6119060867
453PhosphorylationADIASVGSPFARASI
HHHHHCCCHHHHHHH		18.0619060867
459PhosphorylationGSPFARASIKSAKLE
CCHHHHHHHHHCCCC		25.6229899451
462PhosphorylationFARASIKSAKLENST
HHHHHHHHCCCCCCC		29.0329899451
468PhosphorylationKSAKLENSTFFHKKE
HHCCCCCCCCCCHHH		19.7420415495
469PhosphorylationSAKLENSTFFHKKER
HCCCCCCCCCCHHHH		41.7320415495
598PhosphorylationRIFKVTKYWASLRNL
HHHHHHHHHHHHHHH		9.2428576409
752PhosphorylationAKEVAEVSPLSAANM
HHHHHHHCCCCHHHH		16.1925521595
755PhosphorylationVAEVSPLSAANMSIA
HHHHCCCCHHHHHHH		28.8122324799
760PhosphorylationPLSAANMSIAVKEQQ
CCCHHHHHHHHHHHH		13.7525521595
792PhosphorylationRKQNLLASREALYGD
HHHHHHHHHHHHHHC		30.5325521595
797PhosphorylationLASREALYGDAAERW
HHHHHHHHHCHHHHC		21.7324925903
836PhosphorylationQENRNNNTNKSRAPE
CCCCCCCCCCCCCCH		46.2627180971
839PhosphorylationRNNNTNKSRAPEALR
CCCCCCCCCCCHHHC		35.4327180971
867PhosphorylationARRAWPGSPERAPGR
HHHHCCCCCCCCCCC		21.3622324799
915PhosphorylationGDAPRRHTHRPVAEG
CCCCCCCCCCCCCCC		20.1229899451
982MethylationPAHDDRERRHRRRKE
CCCCHHHHHHHHHHH		40.37-
998O-linked_GlycosylationQGSGVPVSGPNLSTT
CCCCCCCCCCCCCCC		60.3055411439
1033PhosphorylationMKNNKLATGEPASPH
HHCCCCCCCCCCCCC		53.1429899451
1038PhosphorylationLATGEPASPHDSLGH
CCCCCCCCCCCCCCC		33.2222817900
1042PhosphorylationEPASPHDSLGHSGLP
CCCCCCCCCCCCCCC		32.9619060867
1046PhosphorylationPHDSLGHSGLPPSPA
CCCCCCCCCCCCCCC		39.9821183079
1051PhosphorylationGHSGLPPSPAKIGNS
CCCCCCCCCCCCCCC		35.2319060867
1077PhosphorylationQNAASRRTPNNPGNP
CCHHHCCCCCCCCCC		29.2929899451
1092PhosphorylationSNPGPPKTPENSLIV
CCCCCCCCCCCCEEE		41.42-
1096PhosphorylationPPKTPENSLIVTNPS
CCCCCCCCEEECCCC		20.15-
1172PhosphorylationGPKPMPPYSSMFILS
CCCCCCCCCCEEEEE		13.9123140645
1173PhosphorylationPKPMPPYSSMFILST
CCCCCCCCCEEEEEC		22.5423140645
1174PhosphorylationKPMPPYSSMFILSTT
CCCCCCCCEEEEECC		16.3323140645
1179PhosphorylationYSSMFILSTTNPLRR
CCCEEEEECCCHHHH		28.5023140645
1180PhosphorylationSSMFILSTTNPLRRL
CCEEEEECCCHHHHH		27.4423140645
1181PhosphorylationSMFILSTTNPLRRLC
CEEEEECCCHHHHHH		31.3123140645
1190PhosphorylationPLRRLCHYILNLRYF
HHHHHHHHHHHHHHH		13.2023140645
1476PhosphorylationGDKMMEEYSLEKNER
HHHHHHHHCCCCCHH		12.7828576409
1491PhosphorylationACIDFAISAKPLTRH
HHHHHHHHCCCCCCC		27.15-
1493UbiquitinationIDFAISAKPLTRHMP
HHHHHHCCCCCCCCC		33.50-
1607N-linked_GlycosylationEFGNNFINLSFLRLF
ECCCCCCCHHHHHHH		26.04-
1898UbiquitinationDLLVTPHKSTDLTVG
CEEECCCCCCCCHHH		57.1422790023
1935PhosphorylationMREEQNRTPLMFQRM
HHHHHCCCCCCCEEC		28.4625521595
1946PhosphorylationFQRMEPPSPTQEGGP
CEECCCCCCCCCCCC		51.8225521595
1948PhosphorylationRMEPPSPTQEGGPSQ
ECCCCCCCCCCCCCC		43.5224925903
1954PhosphorylationPTQEGGPSQNALPST
CCCCCCCCCCCCCCC		39.0624925903
1960PhosphorylationPSQNALPSTQLDPGG
CCCCCCCCCCCCCCC		29.6324925903
1961PhosphorylationSQNALPSTQLDPGGG
CCCCCCCCCCCCCCC		31.0724925903
1979PhosphorylationHEGGMKESPSWVTQR
CCCCCCCCCHHHHHH		20.7925521595
1981PhosphorylationGGMKESPSWVTQRAQ
CCCCCCCHHHHHHHH		43.3825521595
1984PhosphorylationKESPSWVTQRAQEMF
CCCCHHHHHHHHHHH		13.1822807455
1994PhosphorylationAQEMFQKTGTWSPER
HHHHHHHHCCCCCCC		29.1229899451
1996PhosphorylationEMFQKTGTWSPERGP
HHHHHHCCCCCCCCC		28.1824925903
1998PhosphorylationFQKTGTWSPERGPPI
HHHHCCCCCCCCCCC		19.4024925903
2014PhosphorylationMPNSQPNSQSVEMRE
CCCCCCCCCCCCHHH		30.4324925903
2016PhosphorylationNSQPNSQSVEMREMG
CCCCCCCCCCHHHCC		21.6224925903
2024PhosphorylationVEMREMGTDGYSDSE
CCHHHCCCCCCCCCC		25.5824925903
2027PhosphorylationREMGTDGYSDSEHYL
HHCCCCCCCCCCCCC		16.4724925903
2028PhosphorylationEMGTDGYSDSEHYLP
HCCCCCCCCCCCCCC		39.9425521595
2030PhosphorylationGTDGYSDSEHYLPME
CCCCCCCCCCCCCCC		21.9724925903
2033PhosphorylationGYSDSEHYLPMEGQT
CCCCCCCCCCCCCCC		14.4024925903
2040PhosphorylationYLPMEGQTRAASMPR
CCCCCCCCCCCCCCC		32.8824925903
2044PhosphorylationEGQTRAASMPRLPAE
CCCCCCCCCCCCCHH		28.4724719451
2066PhosphorylationPRGNDLSTISDTSPM
CCCCCCCCCCCCCCC		31.6224925903
2068PhosphorylationGNDLSTISDTSPMKR
CCCCCCCCCCCCCCC		34.6224925903
2070PhosphorylationDLSTISDTSPMKRSA
CCCCCCCCCCCCCCH		28.1224925903
2071PhosphorylationLSTISDTSPMKRSAS
CCCCCCCCCCCCCHH		28.1725521595
2076PhosphorylationDTSPMKRSASVLGPK
CCCCCCCCHHHHCCC		21.2729899451
2078PhosphorylationSPMKRSASVLGPKAR
CCCCCCHHHHCCCCC		21.0822324799
2091PhosphorylationARRLDDYSLERVPPE
CCCCCCCCCCCCCCH		30.6522817900
2198PhosphorylationRAREQRWSRSPSEGR
HHHHHHHCCCCCCCC		25.6822324799
2200PhosphorylationREQRWSRSPSEGREH
HHHHHCCCCCCCCCC		27.5422324799
2202PhosphorylationQRWSRSPSEGREHTT
HHHCCCCCCCCCCCC		54.6623684622
2208PhosphorylationPSEGREHTTHRQGSS
CCCCCCCCCCCCCCC		21.3922324799
2209PhosphorylationSEGREHTTHRQGSSS
CCCCCCCCCCCCCCC		19.5722324799
2214PhosphorylationHTTHRQGSSSVSGSP
CCCCCCCCCCCCCCC		15.8826160508
2215PhosphorylationTTHRQGSSSVSGSPA
CCCCCCCCCCCCCCC		41.4026160508
2216PhosphorylationTHRQGSSSVSGSPAP
CCCCCCCCCCCCCCC		23.2326160508
2218PhosphorylationRQGSSSVSGSPAPST
CCCCCCCCCCCCCCC		35.1926160508
2220PhosphorylationGSSSVSGSPAPSTSG
CCCCCCCCCCCCCCC		15.4726824392
2224PhosphorylationVSGSPAPSTSGTSTP
CCCCCCCCCCCCCCC		36.9926160508
2225PhosphorylationSGSPAPSTSGTSTPR
CCCCCCCCCCCCCCC		30.0726160508
2226PhosphorylationGSPAPSTSGTSTPRR
CCCCCCCCCCCCCCC		44.4026160508
2228PhosphorylationPAPSTSGTSTPRRGR
CCCCCCCCCCCCCCC		29.2425777480
2230PhosphorylationPSTSGTSTPRRGRRQ
CCCCCCCCCCCCCCC		22.2025777480
2241PhosphorylationGRRQLPQTPCTPRPL
CCCCCCCCCCCCCCC		20.5626160508
2244PhosphorylationQLPQTPCTPRPLVSY
CCCCCCCCCCCCCCC		24.4426160508
2250PhosphorylationCTPRPLVSYSPAPRR
CCCCCCCCCCCCCCC		27.8126160508
2251PhosphorylationTPRPLVSYSPAPRRP
CCCCCCCCCCCCCCC		15.9326160508
2252PhosphorylationPRPLVSYSPAPRRPA
CCCCCCCCCCCCCCH		13.6926824392
2273PhosphorylationPAAPPGGSPRGCRRA
CCCCCCCCCCCCCCC		19.8325521595
2298PhosphorylationPRPRGADYTEPDSPR
CCCCCCCCCCCCCCC		16.6925777480
2299PhosphorylationRPRGADYTEPDSPRE
CCCCCCCCCCCCCCC		41.4026160508
2303PhosphorylationADYTEPDSPREPPGG
CCCCCCCCCCCCCCC		36.2525521595
2318PhosphorylationAHDPAPRSPRTPRAA
CCCCCCCCCCCCCCC		20.0626824392
2321PhosphorylationPAPRSPRTPRAAGCA
CCCCCCCCCCCCCCC		22.1029899451
2329PhosphorylationPRAAGCASPRHGRRL
CCCCCCCCCCCCCCC		26.9222324799
2360PhosphorylationRRGAHDAYSESEDDW
CCCCCCCCCCCCCCC		21.0129899451
2361PhosphorylationRGAHDAYSESEDDWC
CCCCCCCCCCCCCCC		36.0525521595
2363PhosphorylationAHDAYSESEDDWC--
CCCCCCCCCCCCC--		40.1425521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAC1A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAC1A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAC1A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CACB1_MOUSECacnb1physical
10328888
CACB3_MOUSECacnb3physical
10328888
CACB4_MOUSECacnb4physical
10328888
CACB2_MOUSECacnb2physical
16787652
CACB3_MOUSECacnb3physical
16787652
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAC1A_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752; SER-1981; TYR-2027;SER-2220 AND SER-2273, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory