FBX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX2_MOUSE
• UniProt AC: Q80UW2
• Protein Name: F-box only protein 2
• Gene Name: Fbxo2
• Organism: Mus musculus (Mouse).
• Sequence Length: 297
• Subcellular Localization: Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type..
• Protein Sequence: MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQLREAEEEEEAEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWSDVEHGGDGWRVEELPGDNGVEFTQDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSENEDVLAEFATGQVAVPEDGSWMEISHTFIDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	DGDGDPESVSHPEEA CCCCCHHHCCCCCCC	34.02	25293948
11	Phosphorylation	DGDPESVSHPEEASP CCCHHHCCCCCCCCC	42.47	25293948
17	Phosphorylation	VSHPEEASPEEQPEE CCCCCCCCCCCCHHH	35.80	21149613
30	Phosphorylation	EEAGAEASAEEEQLR HHHCCCCCHHHHHHH	27.93	21149613
75	S-nitrosylation	ATELVQACRLVCLRW HHHHHHHHHHHHHHH	1.61	22588120
83	Ubiquitination	RLVCLRWKELVDGAP HHHHHHHHHHHCCCE	34.43	-
106	Phosphorylation	EGLVPEGSADEERDH CCCCCCCCCCHHCHH	30.77	14990996
141	Phosphorylation	EEDLEGWSDVEHGGD CCCCCCCCCCCCCCC	42.51	25521595
180	S-palmitoylation	FASSFEWCRKAQVID HHHHHHHHHHCCEEE	2.23	28680068

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_MOUSE	Vcp	physical	15723043
CUL1_MOUSE	Cul1	physical	17215248
SKP1_MOUSE	Skp1a	physical	17215248
SKP1_MOUSE	Skp1a	physical	17494702
FBX2_MOUSE	Fbxo2	physical	27487926
SHPS1_MOUSE	Sirpa	physical	14701835

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.