ARBK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARBK2_MOUSE
• UniProt AC: Q3UYH7
• Protein Name: Beta-adrenergic receptor kinase 2
• Gene Name: Adrbk2
• Organism: Mus musculus (Mouse).
• Sequence Length: 688
• Protein Description: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors..
• Protein Sequence: MADLEAVLADVSYLMAMEKSKTAPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFNQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLRRSRQMYDAYIMRELLSSTHQFSKQAVEHVQSHLSKKQVTATLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCGGGGARELKEHIFFKGIDWQHVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLVISERWQQEVVETIYDAVNADTDKIEARRKAKNKQLGQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQSLLTMEQIMSVEETQIKDRKCILLRIKGGKQFVLQCESDPEFAQWLKELTCTFNEAQRLLRRAPKFLNKPRAAILEFSKPPLCHRNSSGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	AVLADVSYLMAMEKS HHHHHHHHHHHHHHC	10.59	22817900
41	O-linked_Glycosylation	LPEPSIRSVMQRYLA CCCHHHHHHHHHHHH	21.92	30059200
344	Ubiquitination	GLACDFSKKKPHASV CEECCCCCCCCCCCC	65.88	-
356	Phosphorylation	ASVGTHGYMAPEVLQ CCCCCCCCCCHHHHH	5.19	-
389	Phosphorylation	FKLLRGHSPFRQHKT HHHHHCCCHHHHCCC	28.67	-
487	Phosphorylation	ADAFDIGSFDEEDTK HHCCCCCCCCHHHCC	29.83	22817900
493	Phosphorylation	GSFDEEDTKGIKLLD CCCCHHHCCCEEEEE	34.15	30635358
676	Phosphorylation	RAAILEFSKPPLCHR CEEHHHCCCCCCCCC	34.57	22324799
685	Phosphorylation	PPLCHRNSSGL---- CCCCCCCCCCC----	26.24	22324799
686	Phosphorylation	PLCHRNSSGL----- CCCCCCCCCC-----	47.89	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARBK2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARBK2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARBK2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARBK2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.