AGAP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGAP1_MOUSE
• UniProt AC: Q8BXK8
• Protein Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
• Gene Name: Agap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 857
• Subcellular Localization: Cytoplasm. Associates with the endocytic compartment..
• Protein Description: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system (By similarity)..
• Protein Sequence: MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSTNPRVIDDVRARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLAKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSDATVIANSAISSDTGLGDSVCSSPSISSSTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENLEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCDTQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPMELIKVMSSIGNELANSVWEEGSQGRTKPSLDSTREEKERWIRAKYEQKLFLAPLPCTEFSLGQQLLRATAEEDLRTVILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLSRKSNSRNNSSGRAPSVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNYQQQLA -------CCHHHHHH	10.72	-
101	Phosphorylation	GTYVQEESPEGGRFK CCEEEEECCCCCCCE	27.74	26239621
300	Phosphorylation	LRIDVPPTANTPTPV ECCCCCCCCCCCCCC	26.86	28066266
303	Phosphorylation	DVPPTANTPTPVRKQ CCCCCCCCCCCCCCC	26.52	26824392
305	Phosphorylation	PPTANTPTPVRKQSK CCCCCCCCCCCCCCH	32.17	28066266
311	Phosphorylation	PTPVRKQSKRRSNLF CCCCCCCCHHHHCCC	31.03	29514104
315	Phosphorylation	RKQSKRRSNLFTSRK CCCCHHHHCCCCCCC	41.75	27180971
320	Phosphorylation	RRSNLFTSRKGSDPD HHHCCCCCCCCCCCH	25.35	24759943
335	Phosphorylation	KEKKGLESRADSIGS HHHHCHHHHHHHCCC	37.50	29899451
339	Phosphorylation	GLESRADSIGSGRAI CHHHHHHHCCCCCCE	28.06	25521595
342	Phosphorylation	SRADSIGSGRAIPIK HHHHHCCCCCCEECH	24.36	26643407
414	Phosphorylation	GKRPPRATSACAPIS CCCCCCCCCCCCCCC	20.38	25777480
415	Phosphorylation	KRPPRATSACAPISS CCCCCCCCCCCCCCC	21.99	20415495
421	Phosphorylation	TSACAPISSPKTNGL CCCCCCCCCCCCCCC	39.26	22324799
422	Phosphorylation	SACAPISSPKTNGLA CCCCCCCCCCCCCCC	31.00	25521595
425	Phosphorylation	APISSPKTNGLAKDM CCCCCCCCCCCCCCC	37.59	24759943
512	Phosphorylation	SPSISSSTSPKLDPP CCCCCCCCCCCCCCC	51.50	27149854
521	Phosphorylation	PKLDPPPSPHANRKK CCCCCCCCCCCCCHH	34.78	25521595
534	Phosphorylation	KKHRRKKSTSNFKAD HHHCCCCCCCCCCCC	39.85	27841257
601	Phosphorylation	CESSKNKSRLTSQSE HHHCCCHHHCCCHHH	41.75	23984901
604	Phosphorylation	SKNKSRLTSQSEAMA CCCHHHCCCHHHHHH	24.49	26060331
605	Phosphorylation	KNKSRLTSQSEAMAL CCHHHCCCHHHHHHH	35.98	29899451
607	Phosphorylation	KSRLTSQSEAMALQS HHHCCCHHHHHHHHH	27.39	26026062
656	Phosphorylation	GIHRNLGTHLSRVRS HHHHHHCHHHHHHHC	23.86	-
663	Phosphorylation	THLSRVRSLDLDDWP HHHHHHHCCCCCCCC	24.31	19060867
836	Phosphorylation	ERFVLMATPNLSRKS HHEEEEECCCCCCCC	9.95	26824392
840	Phosphorylation	LMATPNLSRKSNSRN EEECCCCCCCCCCCC	44.28	24453211
843	Phosphorylation	TPNLSRKSNSRNNSS CCCCCCCCCCCCCCC	38.64	23375375
845	Phosphorylation	NLSRKSNSRNNSSGR CCCCCCCCCCCCCCC	43.40	23375375
849	Phosphorylation	KSNSRNNSSGRAPSV CCCCCCCCCCCCCCC	37.41	22817900
850	Phosphorylation	SNSRNNSSGRAPSVI CCCCCCCCCCCCCCC	34.13	24759943
855	Phosphorylation	NSSGRAPSVI----- CCCCCCCCCC-----	31.31	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGAP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGAP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGAP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AGAP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.