dbPTM

WDR7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WDR7_MOUSE
UniProt AC	Q920I9
Protein Name	WD repeat-containing protein 7
Gene Name	Wdr7
Organism	Mus musculus (Mouse).
Sequence Length	1489
Subcellular Localization
Protein Description
Protein Sequence	MAGNSLVLPIVLWGRKAPTHCISSILLTDDGGTIVTGCHDGQICLWDVSVELEVNPRALLFGHTASITCLSKACASGDKRYTVSASANGEMCLWDVNDGRCIEFTKLACTHTGIQFYQFSVGNQQEGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSQRTQEDTVVALSVTGILKVWIVTSEMSGMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSADKVIIWTENGQSYIYKLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDQKDKELVICPPVTRFFYGCKEYLHKLLIQGDSSGRLNIWNIADIAEKQEADEGLKMTTCISLQEAFDKLKPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIIIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVYVWQMDTGALDRCAMGITAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENLQKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDEEEDEEEARRQSREDSDPEYRASKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQAAGKLLHAKAEVGRKLPAAEGVGKGTYTVSRAVTTQHLLSIISLANTLMSMTNATFIGDHMKKGPTRPPRPGTPDLSKARDSPPPSSNIVQGQIKQAAAPVVSARSDADHSGSDSASPALPTCFLVNEGWSQLAAMHCVMLPDLLGLERFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKETIDTWAPYLPQYMDHVISPGVTAEAMQTMAAAPDASGPEAKVQEEEHDLVDDDITAGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTYLLLQPPSPKLPPHSTIRRTATDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQSIHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERSHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVSFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQLRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
319	Ubiquitination	QHSLLDQKDKELVIC CHHHCCCCCCCEEEC	71.13	22790023
337	Ubiquitination	TRFFYGCKEYLHKLL HHHHHCHHHHHHHHH	45.06	22790023
364	Ubiquitination	NIADIAEKQEADEGL EHHHHHHHHHHCCCC	44.40	22790023
412	Phosphorylation	EPLKVTASVYIPAHG CCCEEEEEEEECCCC	13.19	29899451
557	Phosphorylation	KKCIMLASRHLFPIQ HHHHEEECCCCCEEE	19.10	-
636	Phosphorylation	KQAMTRRSLAALKNM HHHHHHHHHHHHHHH	21.04	29899451
650	Phosphorylation	MAHHKLQTLATNLLA HHHHHHHHHHHHHHH	28.88	29899451
658	Phosphorylation	LATNLLASEASDKGN HHHHHHHHHHCCCCC	33.39	29899451
661	Phosphorylation	NLLASEASDKGNLPK HHHHHHHCCCCCCCC	35.48	29899451
663	Ubiquitination	LASEASDKGNLPKYS HHHHHCCCCCCCCCC	47.40	22790023
716	Phosphorylation	RPNTALISPENLQKA CCCEEEECHHHHHHH	27.32	22817900
729	Ubiquitination	KASGSSDKGGSFLTG HHCCCCCCCCCCCCH	68.09	22790023
737	Ubiquitination	GGSFLTGKRAAVLFQ CCCCCCHHHHHHHHH	33.36	27667366
751	Ubiquitination	QQVKETIKENIKEHL HHHHHHHHHHHHHHC	52.72	27667366
772	Phosphorylation	EEEARRQSREDSDPE HHHHHHHHHHCCCHH	35.51	29899451
776	Phosphorylation	RRQSREDSDPEYRAS HHHHHHCCCHHHHHC	50.76	25521595
780	Phosphorylation	REDSDPEYRASKSKP HHCCCHHHHHCCCCC	19.50	29899451
919	Phosphorylation	DHMKKGPTRPPRPGT HHHCCCCCCCCCCCC	65.56	26643407
926	Phosphorylation	TRPPRPGTPDLSKAR CCCCCCCCCCHHHCC	19.13	24899341
930	Phosphorylation	RPGTPDLSKARDSPP CCCCCCHHHCCCCCC	31.48	21454597
935	Phosphorylation	DLSKARDSPPPSSNI CHHHCCCCCCCCCCC	33.48	25521595
939	Phosphorylation	ARDSPPPSSNIVQGQ CCCCCCCCCCCCHHH	41.62	25619855
940	Phosphorylation	RDSPPPSSNIVQGQI CCCCCCCCCCCHHHH	36.03	25619855
1056	Phosphorylation	WAPYLPQYMDHVISP CHHCHHHHHHHCCCC	11.54	29899451
1062	Phosphorylation	QYMDHVISPGVTAEA HHHHHCCCCCCCHHH	17.95	29899451
1115	Phosphorylation	QMKKISTSYEERRKQ HHHHCCCCHHHHHHH	24.61	25521595
1116	Phosphorylation	MKKISTSYEERRKQA HHHCCCCHHHHHHHH	23.15	25521595
1147	Phosphorylation	IEPPKLLTRPRSSSQ CCCCCCCCCCCCCCC	49.41	-
1151	Phosphorylation	KLLTRPRSSSQIPEG CCCCCCCCCCCCCCC	36.70	24925903
1152	Phosphorylation	LLTRPRSSSQIPEGF CCCCCCCCCCCCCCC	27.78	24925903
1153	Phosphorylation	LTRPRSSSQIPEGFG CCCCCCCCCCCCCCC	33.12	25521595
1162	Phosphorylation	IPEGFGLTSGGSNYS CCCCCCCCCCCCCHH	26.21	24925903
1163	Phosphorylation	PEGFGLTSGGSNYSL CCCCCCCCCCCCHHH	46.31	24925903
1166	Phosphorylation	FGLTSGGSNYSLARH CCCCCCCCCHHHHHH	35.80	24925903
1168	Phosphorylation	LTSGGSNYSLARHTC CCCCCCCHHHHHHHH	13.52	25777480
1169	Phosphorylation	TSGGSNYSLARHTCK CCCCCCHHHHHHHHH	21.58	25777480
1179	Phosphorylation	RHTCKALTYLLLQPP HHHHHHHHHHHHCCC	19.58	26239621
1180	Phosphorylation	HTCKALTYLLLQPPS HHHHHHHHHHHCCCC	9.01	26239621
1187	Phosphorylation	YLLLQPPSPKLPPHS HHHHCCCCCCCCCCC	41.15	26239621
1194	Phosphorylation	SPKLPPHSTIRRTAT CCCCCCCCHHHHHHH	31.16	29899451
1195	Phosphorylation	PKLPPHSTIRRTATD CCCCCCCHHHHHHHH	18.57	29899451
1253	Phosphorylation	PAADSARSARHALSL HHHHHHHHHHHHHHH	29.39	-
1455	Phosphorylation	VPPVQPASPGSHNAL CCCCCCCCCCCCHHH	36.16	25521595
1458	Phosphorylation	VQPASPGSHNALKLA CCCCCCCCCHHHHHH	19.56	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WDR7_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WDR7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WDR7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of WDR7_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WDR7_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-935, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1151, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1151; SER-1153 ANDSER-1455, AND MASS SPECTROMETRY.	17114649 [Abstract]