PURA_MOUSE - dbPTM
PURA_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PURA_MOUSE
UniProt AC P42669
Protein Name Transcriptional activator protein Pur-alpha
Gene Name Pura
Organism Mus musculus (Mouse).
Sequence Length 321
Subcellular Localization Nucleus.
Protein Description This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the c-Myc gene. May play a role in the initiation of DNA replication and in recombination..
Protein Sequence MADRDSGSEQGGAALGSGGSLGHPGSGSGSGGGGGGGGGGGGSGGGGGAPGGLQHETQELASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGNKSRLTLSMSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQAQDEPRRALKSEFLVRENRKYYMDLKENQRGRFLRIRQTVNRGPGLGSTQGQTIALPAQGLIEFRDALAKLIDDYGVEEEPAELPEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKYSEEMKKIQEKQREKRAACEQLHQQQQQQQEETTAATLLLQGEEEGEED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MADRDSGSE
------CCCCCCCCC		22.1217242355
6Phosphorylation--MADRDSGSEQGGA
--CCCCCCCCCCCCC		45.1523429704
8PhosphorylationMADRDSGSEQGGAAL
CCCCCCCCCCCCCCC		30.6023429704
17PhosphorylationQGGAALGSGGSLGHP
CCCCCCCCCCCCCCC		40.6120531401
20PhosphorylationAALGSGGSLGHPGSG
CCCCCCCCCCCCCCC		34.4023429704
26PhosphorylationGSLGHPGSGSGSGGG
CCCCCCCCCCCCCCC		33.9523429704
28PhosphorylationLGHPGSGSGSGGGGG
CCCCCCCCCCCCCCC		31.3323429704
30PhosphorylationHPGSGSGSGGGGGGG
CCCCCCCCCCCCCCC		35.6423140645
43PhosphorylationGGGGGGGSGGGGGAP
CCCCCCCCCCCCCCC		37.2223429704
57PhosphorylationPGGLQHETQELASKR
CCCHHHHHHHHHHCC		25.8123429704
62PhosphorylationHETQELASKRVDIQN
HHHHHHHHCCCCCCC		33.3523429704
70MalonylationKRVDIQNKRFYLDVK
CCCCCCCCEEEEECH		27.7526320211
77UbiquitinationKRFYLDVKQNAKGRF
CEEEEECHHHCCCCE		37.1922790023
77MalonylationKRFYLDVKQNAKGRF
CEEEEECHHHCCCCE		37.1926320211
86UbiquitinationNAKGRFLKIAEVGAG
HCCCCEEEEEEECCC		36.8427667366
86AcetylationNAKGRFLKIAEVGAG
HCCCCEEEEEEECCC		36.84-
86MalonylationNAKGRFLKIAEVGAG
HCCCCEEEEEEECCC		36.8426320211
96AcetylationEVGAGGNKSRLTLSM
EECCCCCCCCEEEEE		39.9823806337
96SuccinylationEVGAGGNKSRLTLSM
EECCCCCCCCEEEEE		39.9823806337
96UbiquitinationEVGAGGNKSRLTLSM
EECCCCCCCCEEEEE		39.9827667366
97PhosphorylationVGAGGNKSRLTLSMS
ECCCCCCCCEEEEEE		36.20-
159AcetylationRKYYMDLKENQRGRF
CCEECCCCCCCCCCE		50.8123954790
159UbiquitinationRKYYMDLKENQRGRF
CCEECCCCCCCCCCE		50.8127667366
159SuccinylationRKYYMDLKENQRGRF
CCEECCCCCCCCCCE		50.8123954790
172PhosphorylationRFLRIRQTVNRGPGL
CEEEEEEEHHCCCCC		15.2023984901
181PhosphorylationNRGPGLGSTQGQTIA
HCCCCCCCCCCCEEE		23.7025521595
182PhosphorylationRGPGLGSTQGQTIAL
CCCCCCCCCCCEEEE		34.6125521595
186PhosphorylationLGSTQGQTIALPAQG
CCCCCCCEEEEECCH		18.2925521595
203AcetylationEFRDALAKLIDDYGV
HHHHHHHHHHHHCCC		46.9923954790
221PhosphorylationPAELPEGTSLTVDNK
CCCCCCCCEEEECCE		20.9229899451
228SuccinylationTSLTVDNKRFFFDVG
CEEEECCEEEEEECC		46.2323954790
228AcetylationTSLTVDNKRFFFDVG
CEEEECCEEEEEECC		46.2323954790
238UbiquitinationFFDVGSNKYGVFMRV
EEECCCCCEEEEEEE		45.1122790023
246PhosphorylationYGVFMRVSEVKPTYR
EEEEEEEEECCCCCC		26.7223984901
249SuccinylationFMRVSEVKPTYRNSI
EEEEEECCCCCCCCC		27.8223954790
249MalonylationFMRVSEVKPTYRNSI
EEEEEECCCCCCCCC		27.8226320211
249AcetylationFMRVSEVKPTYRNSI
EEEEEECCCCCCCCC		27.8223954790
251PhosphorylationRVSEVKPTYRNSITV
EEEECCCCCCCCCCC		29.4222817900
252PhosphorylationVSEVKPTYRNSITVP
EEECCCCCCCCCCCC		19.1429899451
255PhosphorylationVKPTYRNSITVPYKV
CCCCCCCCCCCCHHH		15.6123684622
257PhosphorylationPTYRNSITVPYKVWA
CCCCCCCCCCHHHHH		18.4321743459
260PhosphorylationRNSITVPYKVWAKFG
CCCCCCCHHHHHHHC		17.5323984901
261MalonylationNSITVPYKVWAKFGH
CCCCCCHHHHHHHCC		25.8226320211
261AcetylationNSITVPYKVWAKFGH
CCCCCCHHHHHHHCC		25.8223954790
261UbiquitinationNSITVPYKVWAKFGH
CCCCCCHHHHHHHCC		25.8227667366
265MalonylationVPYKVWAKFGHTFCK
CCHHHHHHHCCHHHH		35.8526320211
265AcetylationVPYKVWAKFGHTFCK
CCHHHHHHHCCHHHH		35.8523201123
271GlutathionylationAKFGHTFCKYSEEMK
HHHCCHHHHHHHHHH		4.2024333276
272MalonylationKFGHTFCKYSEEMKK
HHCCHHHHHHHHHHH		47.8526320211
272AcetylationKFGHTFCKYSEEMKK
HHCCHHHHHHHHHHH		47.8523864654
278AcetylationCKYSEEMKKIQEKQR
HHHHHHHHHHHHHHH		50.432372995
291S-palmitoylationQREKRAACEQLHQQQ
HHHHHHHHHHHHHHH		3.1428680068
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PURA_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PURA_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PURA_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
E2F1_MOUSEE2f1physical
10597240
CCNA2_MOUSECcna2physical
15707957
CCNE1_MOUSECcne1physical
15707957
CCNB1_MOUSECcnb1physical
15707957
CCND1_MOUSECcnd1physical
15707957
CCNH_MOUSECcnhphysical
15707957
CDK1_MOUSECdk1physical
15707957
CDK4_MOUSECdk4physical
15707957
H11_MOUSEHist1h1aphysical
15707957
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PURA_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-252, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory