E2F1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E2F1_MOUSE
• UniProt AC: Q61501
• Protein Name: Transcription factor E2F1
• Gene Name: E2f1
• Organism: Mus musculus (Mouse).
• Sequence Length: 430
• Subcellular Localization: Nucleus .
• Protein Description: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. [PubMed: 11672531]
• Protein Sequence: MAVAPAGGQHAPALEALLGAGALRLLDSSQIVIISTAPDVGAPQLPAAPPTGPRDSDVLLFATPQAPRPAPSAPRPALGRPPVKRRLDLETDHQYLAGSSGPFRGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSRSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTMVGIGKRLEGLTQDLQQLQESEQQLDHLMHICTTQLQLLSEDSDTQRLAYVTCQDLRSIADPAEQMVIVIKAPPETQLQAVDSSETFQISLKSKQGPIDVFLCPEESADGISPGKTSCQETSSGEDRTADSGPAGPPPSPPSTSPALDPSQSLLGLEQEAVLPRMGHLRVPMEEDQLSPLVAADSLLEHVKEDFSGLLPGEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	Acetylation	GRGRHPGKGVKSPGE CCCCCCCCCCCCCCC	66.05	-
115	Acetylation	RHPGKGVKSPGEKSR CCCCCCCCCCCCCHH	60.65	-
116	Phosphorylation	HPGKGVKSPGEKSRY CCCCCCCCCCCCHHC	35.41	-
120	Acetylation	GVKSPGEKSRYETSL CCCCCCCCHHCCHHC	46.26	-
318	Phosphorylation	TSSGEDRTADSGPAG CCCCCCCCCCCCCCC	47.33	25777480
321	Phosphorylation	GEDRTADSGPAGPPP CCCCCCCCCCCCCCC	44.18	25777480
329	Phosphorylation	GPAGPPPSPPSTSPA CCCCCCCCCCCCCCC	56.04	25777480
332	Phosphorylation	GPPPSPPSTSPALDP CCCCCCCCCCCCCCH	44.92	25777480
333	Phosphorylation	PPPSPPSTSPALDPS CCCCCCCCCCCCCHH	44.49	25777480
334	Phosphorylation	PPSPPSTSPALDPSQ CCCCCCCCCCCCHHH	16.71	25777480
340	Phosphorylation	TSPALDPSQSLLGLE CCCCCCHHHHHHCCC	31.87	25777480
342	Phosphorylation	PALDPSQSLLGLEQE CCCCHHHHHHCCCHH	29.87	25777480
368	Phosphorylation	PMEEDQLSPLVAADS CCCHHCCHHHHHHHH	15.56	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Mdm2	P23804	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E2F1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E2F1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SP1_MOUSE	Sp1	physical	10547281
NECD_MOUSE	Ndn	physical	12198120
NECD_MOUSE	Ndn	genetic	12198120
SP1_MOUSE	Sp1	physical	8657141
PURA_MOUSE	Pura	physical	10597240
NSE3_MOUSE	Ndnl2	physical	20211142
HDAC1_MOUSE	Hdac1	physical	16484221
RB_MOUSE	Rb1	physical	12799438
HDAC1_MOUSE	Hdac1	physical	12799438
TOPB1_MOUSE	Topbp1	physical	17006541
TFDP1_MOUSE	Tfdp1	physical	14739777
SRTD2_HUMAN	SERTAD2	physical	11331592
KAT2A_MOUSE	Kat2a	physical	23868976
SMCA4_MOUSE	Smarca4	physical	23868976

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.