NSE3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSE3_MOUSE
• UniProt AC: Q9CPR8
• Protein Name: Non-structural maintenance of chromosomes element 3 homolog
• Gene Name: Nsmce3
• Organism: Mus musculus (Mouse).
• Sequence Length: 279
• Subcellular Localization: Cytoplasm . Nucleus . Chromosome, telomere.
• Protein Description: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. [PubMed: 14593116]
• Protein Sequence: MLQKPRGRGRPSTQADPERDWGGAGEEGPSTSRAAGGSSQGSRASLSAPTVGPRTQKQLELKVAELVQFLLIKDQKKIPIKRTDILKHVVGDYRDVYPNLLKLAAERLQYVFGYKLVELEPKSHSYILINMLEPVEADAEMRGDQGTPISGLLMIVLGLIFMKGNTITETEVWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPHTDPVDYELQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPTQYCEALADEESRARPATASAPATSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	TSRAAGGSSQGSRAS CCCCCCCCCCCCCCC		25619855
39	Phosphorylation	SRAAGGSSQGSRASL CCCCCCCCCCCCCCC		25619855
42	Phosphorylation	AGGSSQGSRASLSAP CCCCCCCCCCCCCCC		25619855
45	Phosphorylation	SSQGSRASLSAPTVG CCCCCCCCCCCCCCC		25619855
47	Phosphorylation	QGSRASLSAPTVGPR CCCCCCCCCCCCCCC		28066266
194	Acetylation	HLIFGDPKKLITEDF EEECCCHHHHCCHHH		23864654
277	Phosphorylation	ATASAPATSS----- CCCCCCCCCC-----		28066266
278	Phosphorylation	TASAPATSS------ CCCCCCCCC------		19060867
279	Phosphorylation	ASAPATSS------- CCCCCCCC-------		19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSE3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSE3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSE3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NSE1_MOUSE	Nsmce1	physical	24911587

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.