NSE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSE1_MOUSE
• UniProt AC: Q9D720
• Protein Name: Non-structural maintenance of chromosomes element 1 homolog
• Gene Name: Nsmce1
• Organism: Mus musculus (Mouse).
• Sequence Length: 266
• Subcellular Localization: Nucleus . Chromosome, telomere .
• Protein Description: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair..
• Protein Sequence: MQGSTRRAGAMTDVHRRFLQLLMTHGVLEEWEVRRLQNHCYQVHDRNATVDKLEDFINNINSVLESLYIEIKKGVTEDDGRPIYALVNLATTSVSKMATDFAENELDLFRKALELIVDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQSKWLIEKEGEFTLHGRAILEMEQFIRESYPDSVKMCNICHGLLIQGQSCETCGIRMHLPCVAKYFQSIPEPHCPHCNDYWPHDIPEVYNPEKEREAGISKSSRKSLRTRQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MQGSTRRAGAMT ---CCCCCCCCCCCH	30.88	28576409
7	Phosphorylation	-MQGSTRRAGAMTDV -CCCCCCCCCCCHHH	37.14	-
13	Phosphorylation	RRAGAMTDVHRRFLQ CCCCCCHHHHHHHHH	22.57	-
62	Phosphorylation	DFINNINSVLESLYI HHHHHHHHHHHHHHH	25.04	26060331
66	Phosphorylation	NINSVLESLYIEIKK HHHHHHHHHHHHHCC	23.47	26060331
68	Phosphorylation	NSVLESLYIEIKKGV HHHHHHHHHHHCCCC	13.04	26060331

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSE1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSE1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NSE1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.