CCNH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCNH_MOUSE
• UniProt AC: Q61458
• Protein Name: Cyclin-H
• Gene Name: Ccnh
• Organism: Mus musculus (Mouse).
• Sequence Length: 323
• Subcellular Localization: Nucleus.
• Protein Description: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle..
• Protein Sequence: MYHSSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPNDPVFLEPHEELTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQERALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDIKTRYPMLENPEILRKTADDFLSRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSDEVAVLKQKLERCHSSDLALNAVTKKRKGYEDDDYVSKKPKQEEEEWTDDDLVDSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MYHSSSQKRHWT ---CCCCCCCCCCCC	24.39	15851034
132	Phosphorylation	FVGNLRESPLGQERA HHCCCCCCCCCHHHH	20.99	26824392
189	Ubiquitination	ENPEILRKTADDFLS CCHHHHHHHHHHHHH	44.62	-
261	Acetylation	SMRNLVKKYEPPRSD HHHHHHHHHCCCCCC	47.57	7744217
302	Phosphorylation	KGYEDDDYVSKKPKQ CCCCCCCCCCCCCCH	17.39	25159016
304	Phosphorylation	YEDDDYVSKKPKQEE CCCCCCCCCCCCHHH	28.82	25159016
315	Phosphorylation	KQEEEEWTDDDLVDS CHHHCCCCCCHHHHC	32.60	27087446
322	Phosphorylation	TDDDLVDSL------ CCCHHHHCC------	28.62	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	S	Phosphorylation	Kinase	CDK8	Q8R3L8	Uniprot
304	S	Phosphorylation	Kinase	CDK8	Q8R3L8	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCNH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCNH_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDK7_MOUSE	Cdk7	physical	11319144

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.