CDK7_MOUSE - dbPTM
CDK7_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDK7_MOUSE
UniProt AC Q03147
Protein Name Cyclin-dependent kinase 7
Gene Name Cdk7
Organism Mus musculus (Mouse).
Sequence Length 346
Subcellular Localization Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides (By similarity)..
Protein Description Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition..
Protein Sequence MAVDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGVPLQHIFIAAGDDLLELIQGLFLFNPCTRTTASQALKTKYFSNRPGPTPGCQLPRPNCPVEALKEPANPTVATKRKRAEALEQGILPKKLIF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAVDVKSRA
------CCCCHHHHH
13.25-
7Phosphorylation-MAVDVKSRAKRYEK
-CCCCHHHHHHHHHH
37.00-
49PhosphorylationKIKLGHRSEAKDGIN
EEECCCCHHHCCCCC
35.9122871156
161PhosphorylationADFGLAKSFGSPNRA
HHHHHHHHHCCCCCC
29.2725521595
164PhosphorylationGLAKSFGSPNRAYTH
HHHHHHCCCCCCCCH
19.5927087446
169PhosphorylationFGSPNRAYTHQVVTR
HCCCCCCCCHHHHHH
11.0827149854
170PhosphorylationGSPNRAYTHQVVTRW
CCCCCCCCHHHHHHH
12.5926824392
175PhosphorylationAYTHQVVTRWYRAPE
CCCHHHHHHHHCCHH
19.3428833060
324PhosphorylationLKEPANPTVATKRKR
HCCCCCCCCCCHHHH
23.6824759943
327PhosphorylationPANPTVATKRKRAEA
CCCCCCCCHHHHHHH
27.3524759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
164SPhosphorylationKinaseCDK1P11440
Uniprot
164SPhosphorylationKinaseCDK2P97377
Uniprot
170TPhosphorylationKinaseCDK2P97377
Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
164SPhosphorylation

-
164SPhosphorylation

-
170TPhosphorylation

-
170TPhosphorylation

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDK7_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CCNH_MOUSECcnhphysical
11319144
PRGC1_MOUSEPpargc1aphysical
17276355

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDK7_MOUSE

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Related Literatures of Post-Translational Modification

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