CCNA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCNA2_MOUSE
• UniProt AC: P51943
• Protein Name: Cyclin-A2 {ECO:0000303|PubMed:8575639}
• Gene Name: Ccna2 {ECO:0000312|MGI:MGI:108069}
• Organism: Mus musculus (Mouse).
• Sequence Length: 422
• Subcellular Localization: Nucleus . Cytoplasm . Exclusively nuclear during interphase. Detected in the nucleus and the cytoplasm at prophase. Cytoplasmic when associated with SCAPER.
• Protein Description: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle..
• Protein Sequence: MPGTSRHSGRDAGSALLSLHQEDQENVNPEKLAPAQQPRAQAVLKAGNVRGPAPQQKLKTRRVAPLKDLPINDEHVTAGPSWKAVSKQPAFTIHVDEAEETQKRPAELKETECEDALAFNAAVSLPGARKPLTPLDYPMDGSFESPHAMDMSIVLEDKPVNVNEVPDYQEDIHTYLREMEVKCKPKVGYMKRQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYSKKQVLRMEHLVLKVLAFDLAAPTVNQFLTQYFLHLQPANCKVESLAMFLGELSLIDADPYLKYLPSLIAGAAFHLALYTVTGQSWPESLAQQTGYTLESLKPCLVDLHQTYLKAPQHAQQSIREKYKHSKYHSVSLLNPPETLSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MPGTSRHS -------CCCCCCCC	6.61	-
5	Phosphorylation	---MPGTSRHSGRDA ---CCCCCCCCCCHH	33.63	-
14	Phosphorylation	HSGRDAGSALLSLHQ CCCCHHHHHHHHHCH	19.91	22817900
45	Ubiquitination	PRAQAVLKAGNVRGP HHHHHHHHHCCCCCC	47.88	-
67	Acetylation	TRRVAPLKDLPINDE CCCCCCCCCCCCCCC	57.04	23806337
421	Phosphorylation	LNPPETLSV------ CCCCCCCCC------	32.95	19233286

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCNA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCNA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCNA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDK2_MOUSE	Cdk2	physical	10068472
CDN1B_MOUSE	Cdkn1b	physical	8547220
CDK2_MOUSE	Cdk2	physical	8547220
CDK1_MOUSE	Cdk1	physical	8226784
CDK2_MOUSE	Cdk2	physical	8226784
E2F3_MOUSE	E2f3	physical	11980909
CDK2_MOUSE	Cdk2	physical	22898779
CDK2_HUMAN	CDK2	physical	18667424
CDK2_MOUSE	Cdk2	physical	18635963
CDK2_MOUSE	Cdk2	physical	16627785

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.