E2F3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E2F3_MOUSE
• UniProt AC: O35261
• Protein Name: Transcription factor E2F3
• Gene Name: E2f3
• Organism: Mus musculus (Mouse).
• Sequence Length: 457
• Subcellular Localization: Nucleus.
• Protein Description: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters. [PubMed: 20176812]
• Protein Sequence: MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAPGTYIQILTTNPSTTSCATSLQSGALTAGPLLPSVPGTEPAASSLYTTPQGPSSRVGLLQQPPAPGRGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYDTSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVTYQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHRPMKTNNQDHNGNIPKPTSKDLASNNSGHSDCSVSTANLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
144	Phosphorylation	YLSDGLKTPKGKGRA HHCCCCCCCCCCCCC	34.96	30482847
155	Phosphorylation	KGRAALRSPDSPKTP CCCCCCCCCCCCCCC	33.63	25266776
158	Phosphorylation	AALRSPDSPKTPKSP CCCCCCCCCCCCCCC	31.51	25266776
164	Phosphorylation	DSPKTPKSPSEKTRY CCCCCCCCCCHHHCC	34.56	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E2F3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E2F3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E2F3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
USF1_MOUSE	Usf1	physical	15014447
CCNA2_MOUSE	Ccna2	physical	11980909

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.