USF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USF1_MOUSE
• UniProt AC: Q61069
• Protein Name: Upstream stimulatory factor 1
• Gene Name: Usf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 310
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters..
• Protein Sequence: MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGSGAISGYPATQSMTQAVIQGAFTSDDAVDTEGAAAETHYTYFPSTAVGDGSGGTTSGSTTAVVTTQGSEALLGQATPPSTGQFFVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGLEVVIKNDSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
177	Phosphorylation	LQGGSQRSIAPRTHP HCCCCCCCCCCCCCC	18.57	24719451
185	Phosphorylation	IAPRTHPYSPKSEAP CCCCCCCCCCCCCCC	29.96	28833060
186	Phosphorylation	APRTHPYSPKSEAPR CCCCCCCCCCCCCCC	30.24	28542873
189	Phosphorylation	THPYSPKSEAPRTTR CCCCCCCCCCCCCCH	42.23	30635358
214	Ubiquitination	VERRRRDKINNWIVQ HHHHHHHHHHHHHHH	45.59	-
214	Acetylation	VERRRRDKINNWIVQ HHHHHHHHHHHHHHH	45.59	23806337
235	Acetylation	DCSMESTKSGQSKGG CCCCCCCCCCCCCCH	62.96	14756211
262	Phosphorylation	RQSNHRLSEELQGLD HHCCHHHHHHHCCCH	29.05	22817900
309	Phosphorylation	EVVIKNDSN------ EEEEECCCC------	54.56	25168779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
262	S	Phosphorylation	Kinase	PRKDC	P78527	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USF1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F3_MOUSE	E2f3	physical	15014447
HDAC9_MOUSE	Hdac9	physical	21680747
EP300_MOUSE	Ep300	physical	21680747
KAT2B_MOUSE	Kat2b	physical	21680747

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.