RAB1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB1A_MOUSE
• UniProt AC: P62821
• Protein Name: Ras-related protein Rab-1A
• Gene Name: Rab1A
• Organism: Mus musculus (Mouse).
• Sequence Length: 205
• Subcellular Localization: Golgi apparatus . Endoplasmic reticulum . Early endosome . Cytoplasm, cytosol . Membrane . Melanosome . Alternates between membrane-associated and cytosolic forms.
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport..
• Protein Sequence: MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSMNPEYD ------CCCCCHHHH	37.99	26643407
2	Acetylation	------MSSMNPEYD ------CCCCCHHHH	37.99	-
3	Phosphorylation	-----MSSMNPEYDY -----CCCCCHHHHH	22.68	29472430
8	Phosphorylation	MSSMNPEYDYLFKLL CCCCCHHHHHHHHHH	15.90	22499769
10	Phosphorylation	SMNPEYDYLFKLLLI CCCHHHHHHHHHHHH	17.09	22499769
20	Phosphorylation	KLLLIGDSGVGKSCL HHHHHCCCCCCCCCE	30.11	22817900
24	Acetylation	IGDSGVGKSCLLLRF HCCCCCCCCCEEEEE	35.27	22826441
26	S-nitrosocysteine	DSGVGKSCLLLRFAD CCCCCCCCEEEEECC	3.37	-
26	S-nitrosylation	DSGVGKSCLLLRFAD CCCCCCCCEEEEECC	3.37	21278135
39	Phosphorylation	ADDTYTESYISTIGV CCCCCCHHHHHEEEC	21.70	25159016
40	Phosphorylation	DDTYTESYISTIGVD CCCCCHHHHHEEECC	7.83	25159016
42	Phosphorylation	TYTESYISTIGVDFK CCCHHHHHEEECCEE	13.02	25159016
58	Ubiquitination	RTIELDGKTIKLQIW EEEEECCEEEEEEEE	46.90	-
58	Malonylation	RTIELDGKTIKLQIW EEEEECCEEEEEEEE	46.90	26320211
58	Acetylation	RTIELDGKTIKLQIW EEEEECCEEEEEEEE	46.90	23236377
61	Ubiquitination	ELDGKTIKLQIWDTA EECCEEEEEEEECCC	39.30	-
61	Malonylation	ELDGKTIKLQIWDTA EECCEEEEEEEECCC	39.30	26320211
61	Acetylation	ELDGKTIKLQIWDTA EECCEEEEEEEECCC	39.30	23806337
75	Phosphorylation	AGQERFRTITSSYYR CCHHHHHHHHHHHHC	26.37	26239621
77	Phosphorylation	QERFRTITSSYYRGA HHHHHHHHHHHHCCC	15.82	26745281
78	Phosphorylation	ERFRTITSSYYRGAH HHHHHHHHHHHCCCC	16.70	24453211
79	O-(2-cholinephosphoryl)serine	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	-
79	Other	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	-
79	Phosphorylation	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	26745281
80	Phosphorylation	FRTITSSYYRGAHGI HHHHHHHHHCCCCEE	9.28	29472430
103	Ubiquitination	QESFNNVKQWLQEID HHHHHHHHHHHHHHH	37.57	-
112	Phosphorylation	WLQEIDRYASENVNK HHHHHHHHHCCCHHH	15.67	22499769
114	Phosphorylation	QEIDRYASENVNKLL HHHHHHHCCCHHHHH	22.29	22499769
119	Acetylation	YASENVNKLLVGNKC HHCCCHHHHHCCCCC	38.63	22826441
119	Ubiquitination	YASENVNKLLVGNKC HHCCCHHHHHCCCCC	38.63	22790023
125	Ubiquitination	NKLLVGNKCDLTTKK HHHHCCCCCCCCCCC	24.17	22790023
126	S-nitrosylation	KLLVGNKCDLTTKKV HHHCCCCCCCCCCCC	6.34	20925432
126	S-nitrosocysteine	KLLVGNKCDLTTKKV HHHCCCCCCCCCCCC	6.34	-
126	Glutathionylation	KLLVGNKCDLTTKKV HHHCCCCCCCCCCCC	6.34	24333276
131	Ubiquitination	NKCDLTTKKVVDYTT CCCCCCCCCCCCHHH	38.03	22790023
136	Phosphorylation	TTKKVVDYTTAKEFA CCCCCCCHHHHHHHH	8.38	25195567
137	Phosphorylation	TKKVVDYTTAKEFAD CCCCCCHHHHHHHHH	18.80	25367039
138	Phosphorylation	KKVVDYTTAKEFADS CCCCCHHHHHHHHHH	29.51	25367039
145	Phosphorylation	TAKEFADSLGIPFLE HHHHHHHHHCCCCCC	25.68	23984901
187	Succinylation	ATAGGAEKSNVKIQS CCCCCCCCCCCEEEC	46.96	-
187	Malonylation	ATAGGAEKSNVKIQS CCCCCCCCCCCEEEC	46.96	26320211
187	Acetylation	ATAGGAEKSNVKIQS CCCCCCCCCCCEEEC	46.96	23806337
187	Ubiquitination	ATAGGAEKSNVKIQS CCCCCCCCCCCEEEC	46.96	-
191	Malonylation	GAEKSNVKIQSTPVK CCCCCCCEEECCCCC	39.00	26320211
191	Ubiquitination	GAEKSNVKIQSTPVK CCCCCCCEEECCCCC	39.00	-
194	Phosphorylation	KSNVKIQSTPVKQSG CCCCEEECCCCCCCC	37.85	25521595
195	Phosphorylation	SNVKIQSTPVKQSGG CCCEEECCCCCCCCC	18.74	25521595
204	Geranylgeranylation	VKQSGGGCC------ CCCCCCCCC------	2.55	-
205	Geranylgeranylation	KQSGGGCC------- CCCCCCCC-------	7.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
194	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB1A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB1A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.