SRGP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRGP2_MOUSE
• UniProt AC: Q91Z67
• Protein Name: SLIT-ROBO Rho GTPase-activating protein 2
• Gene Name: Srgap2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1071
• Subcellular Localization: Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, postsynaptic cell membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome. Nucleus. Cytopla
• Protein Description: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. May play a role for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia..
• Protein Sequence: MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDIIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLIACVTMDNLQERAVHIRKVLLVLPKPTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPNPRELEGPIYSRGGSMEDYCDSTHGETTSAEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVMSEPPEEKVTARTGASCPSGGHVADIYLANINKQRKRPESGSIRKAFRSDSHGLGSSLTDSSSLGVGASCRPSSQPIMSQNLPKEGPDKCSISGHGSLNSISRHSSLKNRMDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELQELERQSSAKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSASPQATDKSCTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
170	Phosphorylation	VMKTYHMYNADSISA HHHHHHCCCHHHCCH		-
176	Phosphorylation	MYNADSISAQSKLKE CCCHHHCCHHHHHHH		-
203	Phosphorylation	VKQEDRQTPRSPDST HCHHHCCCCCCCCCC		25521595
206	Phosphorylation	EDRQTPRSPDSTANV HHCCCCCCCCCCCCC		25521595
209	Phosphorylation	QTPRSPDSTANVRIE CCCCCCCCCCCCCEE		24925903
210	Phosphorylation	TPRSPDSTANVRIEE CCCCCCCCCCCCEEE		23970565
224	Phosphorylation	EKHVRRSSVKKIEKM EHHHHHHHHHHHHHH		-
378	Phosphorylation	QQLQSRLSTLKIENE HHHHHHHHHCCCCCH		23737553
379	Phosphorylation	QLQSRLSTLKIENEE HHHHHHHHCCCCCHH		23737553
424	Phosphorylation	NSMESVKSTVSETFM CCHHHHHHHHHHHHH		26643407
425	Phosphorylation	SMESVKSTVSETFMS CHHHHHHHHHHHHHC		26643407
427	Phosphorylation	ESVKSTVSETFMSKP HHHHHHHHHHHHCCH		23684622
429	Phosphorylation	VKSTVSETFMSKPSI HHHHHHHHHHCCHHH		26745281
432	Phosphorylation	TVSETFMSKPSIAKR HHHHHHHCCHHHHHH		23984901
435	Phosphorylation	ETFMSKPSIAKRRAN HHHHCCHHHHHHHCC		29514104
492	Phosphorylation	DCSLARRSSTVRKQD HHHHHHCCCCCCCCC		29899451
493	Phosphorylation	CSLARRSSTVRKQDS HHHHHCCCCCCCCCH		29899451
500	Phosphorylation	STVRKQDSSQAIPLV CCCCCCCHHCHHHHH		19060867
501	Phosphorylation	TVRKQDSSQAIPLVV CCCCCCHHCHHHHHH		19060867
529	Phosphorylation	HEGIFRVSGSQVEVN CCCEEEEECCEEEHH		20415495
531	Phosphorylation	GIFRVSGSQVEVNDI CEEEEECCEEEHHHH		20415495
690	Phosphorylation	RELEGPIYSRGGSME HHCCCCCCCCCCCHH		18779572
691	Phosphorylation	ELEGPIYSRGGSMED HCCCCCCCCCCCHHH		21082442
695	Phosphorylation	PIYSRGGSMEDYCDS CCCCCCCCHHHHCCC		25521595
699	Phosphorylation	RGGSMEDYCDSTHGE CCCCHHHHCCCCCCC		25521595
702	Phosphorylation	SMEDYCDSTHGETTS CHHHHCCCCCCCCCC		23984901
703	Phosphorylation	MEDYCDSTHGETTSA HHHHCCCCCCCCCCC		25521595
707	Phosphorylation	CDSTHGETTSAEDST CCCCCCCCCCCCCCC		25521595
708	Phosphorylation	DSTHGETTSAEDSTQ CCCCCCCCCCCCCCC		25521595
709	Phosphorylation	STHGETTSAEDSTQD CCCCCCCCCCCCCCC		23984901
713	Phosphorylation	ETTSAEDSTQDVTAE CCCCCCCCCCCCCCC		25777480
714	Phosphorylation	TTSAEDSTQDVTAEH CCCCCCCCCCCCCCC		23984901
718	Phosphorylation	EDSTQDVTAEHHTSD CCCCCCCCCCCCCCC		23684622
723	Phosphorylation	DVTAEHHTSDDECEP CCCCCCCCCCCCCCC		21183079
724	Phosphorylation	VTAEHHTSDDECEPI CCCCCCCCCCCCCCH		21183079
748	Phosphorylation	GRTARELSFKKGASL CCCHHHHCCCCCCEE		-
787	Phosphorylation	QYIVVQDTEDGVVER EEEEEEECCCCEEEC		28285833
795	Phosphorylation	EDGVVERSSPKSEIE CCCEEECCCCCCCEE		25521595
796	Phosphorylation	DGVVERSSPKSEIEV CCEEECCCCCCCEEE		25521595
799	Phosphorylation	VERSSPKSEIEVMSE EECCCCCCCEEECCC		25521595
805	Phosphorylation	KSEIEVMSEPPEEKV CCCEEECCCCCCCCC		28833060
822	Phosphorylation	RTGASCPSGGHVADI CCCCCCCCCCCCEEE		22807455
830	Phosphorylation	GGHVADIYLANINKQ CCCCEEEEEEECCCC		26026062
843	Phosphorylation	KQRKRPESGSIRKAF CCCCCCCCCCHHHHH		28066266
845	Phosphorylation	RKRPESGSIRKAFRS CCCCCCCCHHHHHCC		22324799
852	Phosphorylation	SIRKAFRSDSHGLGS CHHHHHCCCCCCCCC		26643407
854	Phosphorylation	RKAFRSDSHGLGSSL HHHHCCCCCCCCCCC		26643407
859	Phosphorylation	SDSHGLGSSLTDSSS CCCCCCCCCCCCCCC		26643407
860	Phosphorylation	DSHGLGSSLTDSSSL CCCCCCCCCCCCCCC		26643407
862	Phosphorylation	HGLGSSLTDSSSLGV CCCCCCCCCCCCCCC		26643407
864	Phosphorylation	LGSSLTDSSSLGVGA CCCCCCCCCCCCCCC		26643407
865	Phosphorylation	GSSLTDSSSLGVGAS CCCCCCCCCCCCCCC		26643407
876	Phosphorylation	VGASCRPSSQPIMSQ CCCCCCCCCCCCCCC		28066266
877	Phosphorylation	GASCRPSSQPIMSQN CCCCCCCCCCCCCCC		28066266
882	Phosphorylation	PSSQPIMSQNLPKEG CCCCCCCCCCCCCCC		28066266
896	Phosphorylation	GPDKCSISGHGSLNS CCCCCCCCCCCCCCH		28066266
900	Phosphorylation	CSISGHGSLNSISRH CCCCCCCCCCHHHCC		21743459
903	Phosphorylation	SGHGSLNSISRHSSL CCCCCCCHHHCCHHH		21743459
905	Phosphorylation	HGSLNSISRHSSLKN CCCCCHHHCCHHHHC		28066266
909	Phosphorylation	NSISRHSSLKNRMDS CHHHCCHHHHCCCCC		28382018
916	Phosphorylation	SLKNRMDSPQIRKTA HHHCCCCCHHHHHHH		23527152
927	Methylation	RKTATAGRSKSFNNH HHHHCCCCCCCCCCC		-
928	Phosphorylation	KTATAGRSKSFNNHR HHHCCCCCCCCCCCC		26643407
930	Phosphorylation	ATAGRSKSFNNHRPM HCCCCCCCCCCCCCC		26824392
949	Phosphorylation	IAQDIEATMNSALNE HHHHHHHHHHHHHHH		26643407
952	Phosphorylation	DIEATMNSALNELQE HHHHHHHHHHHHHHH		23984901
964	Phosphorylation	LQELERQSSAKHTPD HHHHHHHHHCCCCCC		30635358
965	Phosphorylation	QELERQSSAKHTPDV HHHHHHHHCCCCCCE		30635358
969	Phosphorylation	RQSSAKHTPDVVLDT HHHHCCCCCCEEECC		26239621
976	Phosphorylation	TPDVVLDTLEPLKTS CCCEEECCCCCCCCC		26239621
982	Phosphorylation	DTLEPLKTSPVVAPT CCCCCCCCCCCCCCC		25521595
983	Phosphorylation	TLEPLKTSPVVAPTS CCCCCCCCCCCCCCC		24925903
989	Phosphorylation	TSPVVAPTSEPSSPL CCCCCCCCCCCCCCH		25521595
990	O-linked_Glycosylation	SPVVAPTSEPSSPLH CCCCCCCCCCCCCHH		28528544
990	Phosphorylation	SPVVAPTSEPSSPLH CCCCCCCCCCCCCHH		25521595
993	Phosphorylation	VAPTSEPSSPLHTQL CCCCCCCCCCHHHHH		25521595
994	Phosphorylation	APTSEPSSPLHTQLL CCCCCCCCCHHHHHH		25521595
998	Phosphorylation	EPSSPLHTQLLKDPE CCCCCHHHHHHCCCC		24925903
1011	Phosphorylation	PEPAFQRSASTAGDI CCHHHHCCCCCHHHH		25521595
1013	Phosphorylation	PAFQRSASTAGDIAC HHHHCCCCCHHHHHH		26824392
1014	Phosphorylation	AFQRSASTAGDIACA HHHCCCCCHHHHHHE		25521595
1027	Phosphorylation	CAFRPVKSVKMAAPV HEEEECCEEEECCCC		25266776
1049	Phosphorylation	KPTVFPKTNATSPGV CCCCCCCCCCCCCCC		25619855
1052	Phosphorylation	VFPKTNATSPGVNSS CCCCCCCCCCCCCCC		25619855
1053	Phosphorylation	FPKTNATSPGVNSSA CCCCCCCCCCCCCCC		25619855
1058	Phosphorylation	ATSPGVNSSASPQAT CCCCCCCCCCCCCCC		25619855
1059	Phosphorylation	TSPGVNSSASPQATD CCCCCCCCCCCCCCC		25619855
1061	Phosphorylation	PGVNSSASPQATDKS CCCCCCCCCCCCCCC		25619855
1065	Phosphorylation	SSASPQATDKSCTV- CCCCCCCCCCCCCC-		25619855
1068	Phosphorylation	SPQATDKSCTV---- CCCCCCCCCCC----		24759943
1070	Phosphorylation	QATDKSCTV------ CCCCCCCCC------		24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRGP2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
927	R	Methylation	Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma membrane protrusions.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRGP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SRGP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.