OPA1_MOUSE - dbPTM
OPA1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPA1_MOUSE
UniProt AC P58281
Protein Name Dynamin-like 120 kDa protein, mitochondrial
Gene Name Opa1 {ECO:0000303|PubMed:28746876, ECO:0000312|MGI:MGI:1921393}
Organism Mus musculus (Mouse).
Sequence Length 960
Subcellular Localization Mitochondrion inner membrane
Single-pass membrane protein . Mitochondrion . Mitochondrion membrane . Detected at contact sites between endoplamic reticulum and mitochondrion membranes.
Protein Description Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. [PubMed: 11847212]
Protein Sequence MWRAGRAAVACEVCQSLVKHSSGIQRNVPLQKLHLVSRSIYRSHHPALKLQRPQLRTPFQQFSSLTHLSLHKLKLSPIKYGYQPRRNFWPARLAARLLKLRYIILGSAVGGGYTAKKTFDEWKDMIPDLSDYKWIVPDFIWEIDEYIDLEKIRKALPSSEDLASLAPDLDKITESLSLLKDFFTAGSPGETAFRATDHGSESDKHYRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQGRLKDTENAIENMIGPDWKKRWMYWKNRTQEQCVHNETKNELEKMLKVNDEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFIDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKVKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
228AcetylationELLHTQLKYQRILER
HHHHHHHHHHHHHHH		29.5323201123
228MalonylationELLHTQLKYQRILER
HHHHHHHHHHHHHHH		29.5326320211
243 (in isoform 2)Ubiquitination-6.63-
265 (in isoform 2)Acetylation-3.55-
318PhosphorylationARIFPRGSGEMMTRS
CCCCCCCCCCCCCCC		32.6220139300
323PhosphorylationRGSGEMMTRSPVKVT
CCCCCCCCCCCEEEE		27.0420139300
342AcetylationPHHVALFKDSSREFD
CCEEEEECCCCCCCC		58.5123954790
344PhosphorylationHVALFKDSSREFDLT
EEEEECCCCCCCCCC		31.7020495213
345PhosphorylationVALFKDSSREFDLTK
EEEECCCCCCCCCCH		46.0620495213
375S-nitrosylationRKNVKEGCTVSPETI
HCCCCCCCEECCCCE		3.4021278135
375S-nitrosocysteineRKNVKEGCTVSPETI
HCCCCCCCEECCCCE		3.40-
383PhosphorylationTVSPETISLNVKGPG
EECCCCEEEECCCCC		22.7028464351
474MalonylationTKVDLAEKNVASPSR
EEHHHHHCCCCCHHH		51.6326320211
508PhosphorylationVVTGKGNSSESIEAI
EEECCCCCHHHHHHH		44.1229899451
531PhosphorylationQNSKLLKTSMLKAHQ
HCCCHHHHHHHHHHC		21.24-
532PhosphorylationNSKLLKTSMLKAHQV
CCCHHHHHHHHHHCC		22.11-
549PhosphorylationRNLSLAVSDCFWKMV
CCHHHHHHHHHHHHH		24.0528285833
551S-nitrosocysteineLSLAVSDCFWKMVRE
HHHHHHHHHHHHHHH		3.23-
551S-nitrosylationLSLAVSDCFWKMVRE
HHHHHHHHHHHHHHH		3.2321278135
582PhosphorylationETEWKNNYPRLRELD
CHHHHHCCHHHHHCC		10.10-
596AcetylationDRNELFEKAKNEILD
CHHHHHHHHHHHHHH		58.2823201123
612PhosphorylationVISLSQVTPKHWEEI
HHHHHHCCHHHHHHH		20.9829899451
633 (in isoform 2)Acetylation-2.32-
652PhosphorylationNSGTFNTTVDIKLKQ
CCCCCEEEEEEEHHH		19.7917203969
658MalonylationTTVDIKLKQWTDKQL
EEEEEEHHHCCCCCC		38.4926320211
663AcetylationKLKQWTDKQLPNKAV
EHHHCCCCCCCCHHH		46.4923954790
699AcetylationEHDDIFDKLKEAVKE
CCCCHHHHHHHHHHH		51.1923954790
705AcetylationDKLKEAVKEESIKRH
HHHHHHHHHHHHHHH		63.917623909
710AcetylationAVKEESIKRHKWNDF
HHHHHHHHHHCCCCH		58.707623921
786S-nitrosylationKNRTQEQCVHNETKN
CCCCHHHHHCHHCHH		3.1121278135
786S-nitrosocysteineKNRTQEQCVHNETKN
CCCCHHHHHCHHCHH		3.11-
808PhosphorylationVNDEHPAYLASDEIT
CCCCCHHHHCCCHHH		13.78-
808NitrationVNDEHPAYLASDEIT
CCCCCHHHHCCCHHH		13.78-
811PhosphorylationEHPAYLASDEITTVR
CCHHHHCCCHHHHHH		32.9327742792
815PhosphorylationYLASDEITTVRKNLE
HHCCCHHHHHHHHHH		19.7229899451
834AcetylationEVDPSLIKDTWHQVY
CCCHHHHHHHHHHHH		55.1623201123
871 (in isoform 2)Acetylation-44.85-
923AcetylationDFAEDGEKKVKLLTG
HHHHHCHHHEHHHHC		69.2823864654
929PhosphorylationEKKVKLLTGKRVQLA
HHHEHHHHCCHHHHH		51.6019854140
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OPA1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPA1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPA1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of OPA1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPA1_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-652, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory