| UniProt ID | AGRB2_MOUSE | |
|---|---|---|
| UniProt AC | Q8CGM1 | |
| Protein Name | Adhesion G protein-coupled receptor B2 | |
| Gene Name | Adgrb2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1561 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition. [PubMed: 12218411] | |
| Protein Sequence | MTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCTHFAPRLLPLDHYLVNFTCLRPGPEEATARAESEVGRPEEEEEEAAAAASGLELCGGSGPFTFLHFDKNFVQLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGEAGANPATTTSPGPPVAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSSSCANGTQQRSRKCSVAGPAWATCAGALTDTRECSNLDCPATDGKWGPWNAWSLCSKTCDTGWQRRFRMCQASGTQGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKRAAAGEIIYNKCPPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDSENKDKWDDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPISAVSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATPGAATAGSPGRGRGPGTVPPGPGHAHQRLLPADPEESSSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVELSYIINGTTDPHCASWDYSRADTNSGDWNTESCQTLETQAAHTRCQCQHLSTFAVLAQPPKDLTLELAGAPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGVSDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGGLSFSPLPGNILVPMAASPGLGEPPPPQETNPVYMCGEGGLRQLDLTWIRQSEPGSEGDYMVLPRRTLSLQPGGGGTAGEEAPRARPEGTPRRAAKTVAHTEGYPSFLSVEHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKLGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSSAKEKPSPPGGRPGLSQHRRHQSWSTFKSMTLGSLPPKPRERLALHRTAAWEPTEPPDGDFQTEV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 94 | N-linked_Glycosylation | PLDHYLVNFTCLRPG CCCEEEEEEEEECCC | - | ||
| 182 | N-linked_Glycosylation | EVLLINNNNSSQFTC EEEEECCCCCCCEEE | - | ||
| 183 | N-linked_Glycosylation | VLLINNNNSSQFTCG EEEECCCCCCCEEEE | - | ||
| 347 | N-linked_Glycosylation | LRETRPCNNSATCPV CCCCCCCCCCCCCCC | - | ||
| 381 | Phosphorylation | GSRSRMRTCVPPQHG CCCCCCCCCCCCCCC | 21659604 | ||
| 428 | N-linked_Glycosylation | PCSSSCANGTQQRSR CCCHHHCCCCCCCCC | - | ||
| 551 | N-linked_Glycosylation | IYNKCPPNASGSASR EEECCCCCCCCCHHH | - | ||
| 623 | Phosphorylation | LLARRTYYSGDLLFS HHHHCCCCCCCEEEE | - | ||
| 636 | N-linked_Glycosylation | FSVDILRNVTDTFKR EEEEEHHHCCHHHHH | - | ||
| 645 | Phosphorylation | TDTFKRATYVPSADD CHHHHHCCCCCCHHH | - | ||
| 646 | Phosphorylation | DTFKRATYVPSADDV HHHHHCCCCCCHHHH | - | ||
| 649 | Phosphorylation | KRATYVPSADDVQRF HHCCCCCCHHHHHHH | - | ||
| 861 | N-linked_Glycosylation | VELSYIINGTTDPHC EEEEEEECCCCCCCC | - | ||
| 1219 | Phosphorylation | GVCRADESEDSPDSC CCCCCCCCCCCCCCC | 29899451 | ||
| 1222 | Phosphorylation | RADESEDSPDSCKNG CCCCCCCCCCCCCCC | 19060867 | ||
| 1225 | Phosphorylation | ESEDSPDSCKNGQLQ CCCCCCCCCCCCCEE | 22324799 | ||
| 1255 | Phosphorylation | VLFKEVNTCNPSTIT EEEEECCCCCHHHCC | 29899451 | ||
| 1259 | Phosphorylation | EVNTCNPSTITGTLS ECCCCCHHHCCEEEE | 29899451 | ||
| 1260 | Phosphorylation | VNTCNPSTITGTLSR CCCCCHHHCCEEEEE | 20415495 | ||
| 1262 | Phosphorylation | TCNPSTITGTLSRLS CCCHHHCCEEEEECC | 29899451 | ||
| 1264 | Phosphorylation | NPSTITGTLSRLSLD CHHHCCEEEEECCCC | 20415495 | ||
| 1266 | Phosphorylation | STITGTLSRLSLDED HHCCEEEEECCCCCC | 20415495 | ||
| 1269 | Phosphorylation | TGTLSRLSLDEDEEP CEEEEECCCCCCCCC | 25521595 | ||
| 1341 | Phosphorylation | IRQSEPGSEGDYMVL EECCCCCCCCCEEEE | 29899451 | ||
| 1345 | Phosphorylation | EPGSEGDYMVLPRRT CCCCCCCEEEECCCE | 16141072 | ||
| 1354 | Phosphorylation | VLPRRTLSLQPGGGG EECCCEEECCCCCCC | 29899451 | ||
| 1440 | Phosphorylation | GERSRTMPRTVPGST CCCCCCCCCCCCCCC | 24719451 | ||
| 1452 | Phosphorylation | GSTMKLGSLERKKLR CCCCCCCCCCCCCCC | 22817900 | ||
| 1461 | Phosphorylation | ERKKLRYSDLDFEKV CCCCCCCCCCCHHHH | 29899451 | ||
| 1476 | Phosphorylation | MHTRKRHSELYHELN HHHHHHHHHHHHHHH | 29899451 | ||
| 1479 | Phosphorylation | RKRHSELYHELNQKF HHHHHHHHHHHHHHH | - | ||
| 1503 | Phosphorylation | SSAKEKPSPPGGRPG CCCCCCCCCCCCCCC | 29899451 | ||
| 1507 | Phosphorylation | EKPSPPGGRPGLSQH CCCCCCCCCCCHHHH | 24719451 | ||
| 1519 | Phosphorylation | SQHRRHQSWSTFKSM HHHHCCCCHHHHHHC | 29899451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AGRB2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AGRB2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AGRB2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AGRB2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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