NTRK3_MOUSE - dbPTM
NTRK3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NTRK3_MOUSE
UniProt AC Q6VNS1
Protein Name NT-3 growth factor receptor
Gene Name Ntrk3
Organism Mus musculus (Mouse).
Sequence Length 825
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation..
Protein Sequence MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEARLDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLHWLYNGQPLRESKIIHMDYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNALGTANQTINGHFLKEPFPESTDFFDFESDASPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
68N-linked_GlycosylationDSGNSNGNASINITD
CCCCCCCCEEEEEEE		34.46-
72N-linked_GlycosylationSNGNASINITDISRN
CCCCEEEEEEECCCC		28.72-
79N-linked_GlycosylationNITDISRNITSIHIE
EEEECCCCCEEEEEE		34.79-
133N-linked_GlycosylationNPHLRYINLSSNRLT
CCCEEEEECCCCCCH		25.57-
141PhosphorylationLSSNRLTTLSWQLFQ
CCCCCCHHHHHHHHH		24.32-
151PhosphorylationWQLFQTLSLRELRLE
HHHHHHCCHHHHHHH		28.86-
163N-linked_GlycosylationRLEQNFFNCSCDIRW
HHHHCCCCCCEEEEH		16.80-
203N-linked_GlycosylationQLPLFRMNISQCDLP
CCCEEEEEHHHCCCC		26.89-
218N-linked_GlycosylationEISVSHVNLTVREGD
CCEEEEEEEEEEECC		25.27-
232N-linked_GlycosylationDNAVITCNGSGSPLP
CCEEEEECCCCCCCC		38.73-
259N-linked_GlycosylationNTHQTNLNWTNVHAI
CCCCCCCCCEEEEEE		45.67-
267N-linked_GlycosylationWTNVHAINLTLVNVT
CEEEEEEEEEEEEEE		27.96-
272N-linked_GlycosylationAINLTLVNVTSEDNG
EEEEEEEEEECCCCC		34.17-
294N-linked_GlycosylationENVVGMSNASVALTV
ECCCCCCCCEEEEEE		27.61-
375N-linked_GlycosylationPTHYNNGNYTLIAKN
CCCCCCCCEEEEEEC		28.83-
388N-linked_GlycosylationKNALGTANQTINGHF
ECCCCCCCCEECCCC		39.09-
477PhosphorylationVISGEEDSASPLHHI
EEECCCCCCCCCCCC		33.6519060867
479PhosphorylationSGEEDSASPLHHINH
ECCCCCCCCCCCCCC		31.7619060867
489PhosphorylationHHINHGITTPSSLDA
CCCCCCCCCHHHCCC		36.9322807455
490PhosphorylationHINHGITTPSSLDAG
CCCCCCCCHHHCCCC		21.1821082442
492PhosphorylationNHGITTPSSLDAGPD
CCCCCCHHHCCCCCC		41.2521082442
493PhosphorylationHGITTPSSLDAGPDT
CCCCCHHHCCCCCCE		31.3221183079
516PhosphorylationPVIENPQYFRQGHNC
CCCCCHHHHCCCCCC		11.2822817900
552PhosphorylationGEGAFGKVFLAECYN
CCCCCHHEEEEHHHC		4.9424719451
555PhosphorylationAFGKVFLAECYNLSP
CCHHEEEEHHHCCCC		8.0524719451
558PhosphorylationKVFLAECYNLSPTKD
HEEEEHHHCCCCCCC		15.6224925903
561PhosphorylationLAECYNLSPTKDKML
EEHHHCCCCCCCCCH		27.2125521595
563PhosphorylationECYNLSPTKDKMLVA
HHHCCCCCCCCCHHH		48.8024925903
682PhosphorylationFVHRDLATRNCLVGA
HHCCHHHCCCCCCCC		29.7022345495
701PhosphorylationKIGDFGMSRDVYSTD
EECCCCCCCCCEECC		26.2122345495
705PhosphorylationFGMSRDVYSTDYYRV
CCCCCCCEECCEEEE		15.339582017
706PhosphorylationGMSRDVYSTDYYRVG
CCCCCCEECCEEEEC		18.0422817900
707PhosphorylationMSRDVYSTDYYRVGG
CCCCCEECCEEEECC		15.4428066266
709PhosphorylationRDVYSTDYYRVGGHT
CCCEECCEEEECCEE		8.029582017
710PhosphorylationDVYSTDYYRVGGHTM
CCEECCEEEECCEEE		11.139582017
716PhosphorylationYYRVGGHTMLPIRWM
EEEECCEEEEEEECC		24.5522807455
730PhosphorylationMPPESIMYRKFTTES
CCCHHEEEEEECCHH		14.69-
820PhosphorylationLGKATPIYLDILG--
HHCCCCEEHHCCC--		10.26-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NTRK3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NTRK3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NTRK3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NTRK3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NTRK3_MOUSE

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Related Literatures of Post-Translational Modification

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