SHSA6_MOUSE - dbPTM
SHSA6_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SHSA6_MOUSE
UniProt AC Q3UH99
Protein Name Protein shisa-6 {ECO:0000305}
Gene Name Shisa6 {ECO:0000303|PubMed:26623514, ECO:0000303|PubMed:26931375, ECO:0000312|MGI:MGI:2685725}
Organism Mus musculus (Mouse).
Sequence Length 525
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
Single-pass type I membrane protein .
Protein Description Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. [PubMed: 26931375 May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway]
Protein Sequence MALRRLLLPPLLLSLLLSLASLHLPPGADAARGRSGNRTLNAGAVGGRRAGGALARGGRELNSTARASGVPEAGSRRGQSAAAAAAAAAAASATVTYETCWGYYDVSGQYDKEFECNNSESGYLYCCGTCYYRFCCKKRHEKLDQRQCTNYQSPVWVQTPSTKVVSPGPENKYDPEKDKTNFTVYITCGVIAFVIVAGVFAKVSYDKAHRPPREMNIHRALADILRQQGPIPIAHCERETISAIDTSPKENTPVRSTSKNHYTPVRTAKQTPGDRQYNHPILSSATQTPTHEKPRMNNILTSATEPYDLSFSRSYQNLAHLPPSYESAVKTNPSKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPRRGLPDEFGMPYDRILSDEQLLSTERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMTKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHHTCYTASKTEVTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37N-linked_GlycosylationAARGRSGNRTLNAGA
CCCCCCCCCEECCCC		34.70-
62N-linked_GlycosylationARGGRELNSTARASG
HCCCCCCCCCHHHCC		32.34-
153PhosphorylationRQCTNYQSPVWVQTP
HHCCCCCCCEEEECC		15.8528285833
159PhosphorylationQSPVWVQTPSTKVVS
CCCEEEECCCCEEEC		15.0228285833
207UbiquitinationFAKVSYDKAHRPPRE
HHHCCCCCCCCCCCH		37.55-
240PhosphorylationIAHCERETISAIDTS
EEECEECEEECCCCC		26.8429899451
242PhosphorylationHCERETISAIDTSPK
ECEECEEECCCCCCC		26.9622324799
246PhosphorylationETISAIDTSPKENTP
CEEECCCCCCCCCCC		40.5925521595
247PhosphorylationTISAIDTSPKENTPV
EEECCCCCCCCCCCC		30.1725521595
249UbiquitinationSAIDTSPKENTPVRS
ECCCCCCCCCCCCCC		64.4627667366
252PhosphorylationDTSPKENTPVRSTSK
CCCCCCCCCCCCCCC		25.0122324799
263PhosphorylationSTSKNHYTPVRTAKQ
CCCCCCCCCCCCCCC		14.0429899451
269UbiquitinationYTPVRTAKQTPGDRQ
CCCCCCCCCCCCCCC		54.8427667366
277PhosphorylationQTPGDRQYNHPILSS
CCCCCCCCCCCCCCC		19.1425159016
283PhosphorylationQYNHPILSSATQTPT
CCCCCCCCCCCCCCC		20.7429899451
284PhosphorylationYNHPILSSATQTPTH
CCCCCCCCCCCCCCC		31.7125159016
286PhosphorylationHPILSSATQTPTHEK
CCCCCCCCCCCCCCC		34.6225159016
288PhosphorylationILSSATQTPTHEKPR
CCCCCCCCCCCCCCC		26.2925159016
290PhosphorylationSSATQTPTHEKPRMN
CCCCCCCCCCCCCHH		46.1629899451
310PhosphorylationATEPYDLSFSRSYQN
CCCCCCCCCCCCCCC		20.4829899451
314PhosphorylationYDLSFSRSYQNLAHL
CCCCCCCCCCCHHCC		29.8529899451
334PhosphorylationSAVKTNPSKYSSLKR
HHHHCCHHHHHHHHH		46.4228059163
336PhosphorylationVKTNPSKYSSLKRLT
HHCCHHHHHHHHHCC		14.0828059163
350PhosphorylationTDKEADEYYMRRRHL
CHHHHHHHHHHHHCC		11.78-
365PhosphorylationPDLAARGTLPLNVIQ
CCHHHCCCCCCCCEE		21.4625777480
374PhosphorylationPLNVIQMSQQKPLPR
CCCCEEHHHCCCCCC		17.0625777480
392PhosphorylationRRPIRAMSQDRVLSP
CCCCHHHCCCCCCCC		28.1322324799
398PhosphorylationMSQDRVLSPRRGLPD
HCCCCCCCCCCCCCC		17.3222324799
411PhosphorylationPDEFGMPYDRILSDE
CCCCCCCHHHHCCHH		14.6829899451
416PhosphorylationMPYDRILSDEQLLST
CCHHHHCCHHHHHCC		36.4124925903
422PhosphorylationLSDEQLLSTERLHSQ
CCHHHHHCCCHHHCC		36.4924925903
423PhosphorylationSDEQLLSTERLHSQD
CHHHHHCCCHHHCCC		25.7022324799
428PhosphorylationLSTERLHSQDPLLSP
HCCCHHHCCCCCCCC		40.6524925903
434PhosphorylationHSQDPLLSPERTAFP
HCCCCCCCCCCCCCC		32.1925521595
438PhosphorylationPLLSPERTAFPEQSL
CCCCCCCCCCCHHHH		30.8722817900
444PhosphorylationRTAFPEQSLSRAISH
CCCCCHHHHHHHHHC		27.0129899451
446PhosphorylationAFPEQSLSRAISHTD
CCCHHHHHHHHHCCC		25.5529899451
450PhosphorylationQSLSRAISHTDVFVS
HHHHHHHHCCCEEEE		21.2522817900
452PhosphorylationLSRAISHTDVFVSTP
HHHHHHCCCEEEECH		27.3719060867
457PhosphorylationSHTDVFVSTPVLDRY
HCCCEEEECHHHHHH		18.6122807455
458PhosphorylationHTDVFVSTPVLDRYR
CCCEEEECHHHHHHH		16.4722817900
502PhosphorylationFASRRHNTVEQLHYI
HHHHCCCCHHHCEEC		21.2122817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SHSA6_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SHSA6_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SHSA6_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SHSA6_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SHSA6_MOUSE

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Related Literatures of Post-Translational Modification

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