AP2A_MOUSE - dbPTM
AP2A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP2A_MOUSE
UniProt AC P34056
Protein Name Transcription factor AP-2-alpha
Gene Name Tfap2a
Organism Mus musculus (Mouse).
Sequence Length 437
Subcellular Localization Nucleus.
Protein Description Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region..
Protein Sequence MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALGSGLGDLPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
119PhosphorylationRGLPHQLSGLDPRRD
CCCCHHHCCCCCCCC
30.64101546439
185PhosphorylationGPVSLSKSNSNAVSA
CCCCCCCCCCCCCEE
41.9623375375
187PhosphorylationVSLSKSNSNAVSAIP
CCCCCCCCCCCEEEE
33.006371355
219PhosphorylationCSVPGRLSLLSSTSK
EECCCCCHHCCCCCC
26.3851163007
223PhosphorylationGRLSLLSSTSKYKVT
CCCHHCCCCCCEEEE
36.3522006019
225PhosphorylationLSLLSSTSKYKVTVA
CHHCCCCCCEEEEHH
35.6229514104
230PhosphorylationSTSKYKVTVAEVQRR
CCCCEEEEHHHHHHH
15.17-
239PhosphorylationAEVQRRLSPPECLNA
HHHHHHCCCHHHHCH
36.2822817900
258PhosphorylationGVLRRAKSKNGGRSL
HHHHHHHHCCCCHHH
30.3010049257
263MethylationAKSKNGGRSLREKLD
HHHCCCCHHHHHHHH
33.64-
287PhosphorylationRRKAANVTLLTSLVE
CHHHCCEEEEEHHHH
18.8327180971
290PhosphorylationAANVTLLTSLVEGEA
HCCEEEEEHHHHCCH
24.1127180971
291PhosphorylationANVTLLTSLVEGEAV
CCEEEEEHHHHCCHH
30.3227180971
420PhosphorylationYLSNNPNSHTDNSAK
HHHCCCCCCCCCCCC
29.0829514104
425PhosphorylationPNSHTDNSAKSSDKE
CCCCCCCCCCCCCHH
39.6228576409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
219SPhosphorylationKinaseAMPKA2Q8BRK8
PSP
239SPhosphorylationKinasePKA-Uniprot
258SPhosphorylationKinasePRKD1Q15139
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
10KSumoylation

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP2A_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP2D_MOUSETfap2dphysical
20211142
CITE2_MOUSECited2physical
11694877
BRE1A_MOUSERnf20physical
24374663

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP2A_MOUSE

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Related Literatures of Post-Translational Modification

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