AKAP9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKAP9_MOUSE
• UniProt AC: Q70FJ1
• Protein Name: A-kinase anchor protein 9
• Gene Name: Akap9
• Organism: Mus musculus (Mouse).
• Sequence Length: 3797
• Subcellular Localization: Golgi apparatus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasmic in parietal cells. Recruited to the Golgi apparatus by GM130/GOLGA2. Localization at the centrosome versus Golgi apparatus may be cell type
• Protein Description: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 2/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 2, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery..
• Protein Sequence: MEDEERQRKLAAGKAKLARFRQRKAQYDGDIPKKQKKKRTSSSKHDSSLHTDQQSGELCSESSQRVDLAGNPDCSGPERKHGQVFSAEPESEISTTADECSSEINGCNSVMKPRKPTDPLREEEFSLDDSSSEQGAQSSQTCLQMVEKELAEKQHDIEELTQELEEMRASFGTEGLKQLQEFEAAIKQRDGIITQLTANLQQARREKDDTMVEFLELTEQSQKLQIQFQHLQANETLQNSTLSRTATDLLQAKRQIFTQQQQLQDYQKKEEDLQAQISFLQEKLRAFEMEKDRKIENLNAKEIQEKQALIDELNTRVVEEEKKTVELKNKVTTADELLGGLHEQLTQRNQEIQSLKLELGNSQQNERKCSEEIKELMRTVEELQKRNLKDSWLETSAVRRVEQETQRKLSHLQAELDEMYGKQIVQMKQELINQHMSQIEELKSQHKREMENTLKSDTNAAISKEQVNLMNAAINELNVRLQETHAQKEELKGELGVVLGEKSALQSQSNDLLEEVRFLREQVQKARQTIAEQENRLSEARKSLSTVEDLKAEIVAASESRKELELKHEAEITNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQPLFSHEEELSKLKEDLEVEHRINIEKLKDNLGIHYKQQIDGLQNEMNRKMESMQCETDNLITQQNQLILENSKLRDLQECLVNSKSEEMNLQINELQKEIEILKQEEKEKGTLEQEVQELQLKTEQLEKQLKEKEDDLQEKCAQLDAENNILKEEKRVLEDKLKMYSPSEQEERSIAVDPSTSKLADSRWQKEVAMLRKETEDLQQQCLYLNEEIEKQRNTFAFAEKNFEVNYQELQREYTCLLKIRDDLEATQTKQALEYESKLRALEEELLSKRGNPXAPKGKSSGIFPSETLEIGEVVEKDTTELMEKLEVTKREKLELSEKVSGLSEQLKQTHCTINSLSAEXRALKQEKEQLLLRCGELELLANPSGTENAAVCPVQMSSYQAGLVMGKVGDSGGSISKISKDLAEESKPMIEDKIPFKESGREQLLLPTRAQEPSHATVEPCESEKLQQELHALKAEQDDLRLQMEAQRICLFVVYSTHADQVRAHMEKEREEALCSLKDELISAQQKKIDELHKMHQCQLQNVKIQETGDEPLQVLIERLQKAVSEKCFHISKTLNNVFDECYTPLKCEMNIEEKENSGVYTSQNQSPELQEYRYEVQDFQESMQVLLGKVTEECRKLSGLQTRLGKIHEQQTDGVALEFAEQNAAEEEAGLLSGCSQSALQSTDVSLESKVSSLPASEKNRECERQVQELQSPVAAGQLQLTETEASHRAEIECLQQRLEAASEAPVQPSLSIDSVVFKGSGAQKPVYCGSCLREYVDGTAKFSDRFEVRQETNMVNLMEKQYQERLEEEIAKVIVSMSIAFAQQTELSRLSEGKENTIQSEQAHTLCSQNKHQLNDITSQSQVGLQTFEATDKBFKEEFKPLSKELGEYRKAVPLSSHDDLDDILKSEEHGLAISEEIFSKDETFIVRKSMHDEVLVSSMDTSRQLILNEQLEDMRQELVRQYEEHQQATEMLRQAHMQQMERQREDQEQLQEEIKRLNEQLTQKSSIDTEHVVSERERVLLEELEALKQLPLAGRKELCCELRHSSTQTQDGHDDQEVEEQTLKDKTLERSPEDALLDRNLSNERYALKKANNRLLKILLEVVKTTSAAEETIGRHVLGILDRSSKGQTASSLLWRSEADASATTCAPEDCARAMDESIPSYPGTAIATHDSIWSKVTEEGAELSQRLVRSGFAGPVIDPENEELMLNISSRLQAAVEKLLEAISETNTQLEHAKVTQTELMRESFRQKQEATESLHCLEELRERLQEESRAREQLAEELNKAESVIDGYSDEKTLFERQIQEKTDIIEHLEQEVLCMNNRLQELESDQRRVEEERQLLCRQREAMRAEAGPVEQQFLQETEKLMKEKLEVQCQAEKVRGDLQKQVKALEIDVEEQVSRFIELEQEKNAELTDLRQQSQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEHQLKAAPRIQPVSEHQAREVEQLTNHLKEKTDRCSELLLSKEQLQRDIQERNEEIEKLECRVRELEQALLASAEPFPKVEDQKRSGAVAADPELSLEVQLQAERDATDRKQKEITNLEEQLEQFREELENKNDEVQELLMQLEIQRKESTTRLQELQQENRLFKDEIEKLGFAMKESDSVSTRDQPMLFGKFAQLIQEKEIEIDRLNEQFIKLQQQLKLTTDNKVIEEQKEQIQDLETQIERLMSEREHEKKQREEEVEQLTGVVEKLQQEVVSTEQQREGARTLPEDEESFKHQLDKVTAEKLVLEQQVETTNQVMTHMNNVLKEINFKMDQITQSLCNLNKECASNEELPSLPKESVHMTVHELGSDNLQPEDAPAQDVTKPLEKQTSLTRLQESPEASRTQEIESLASSVGAKDVELTQCREQTETIQEQAQSETDRLQKKLTDLQRSLEKFAAALVSQVQMEAAQEYVPFHQEKQPVSSAPGSTDIQNANGLTGASTESLIPTVTLRLAEVESRVAEVHSGTMSEKLVGIVGGNASETEKRVIELQKLLEEAEERPEEGGEQSSRDGEVRESYMTSLQKDLGQVKDPLTEAKEKLSYSLEKEKRTGEQESREAPIPEPPSVEVGGCSGLTERTDKVSSSGNQTLQILLRDAAIQTDLQSESSQEEVRDTINQLTKKMEHIQELHAAEILDMESRHILETESLKKEHYVAIQLLTKECETLKEMTQCLRCKEGSSIPELADSVAYQSREVYSSDSESDWGQSQGFDTAIEGREEGETSADLFPKKIKGLVKAVHSEGMQVLSLSSPLCDDGEDRSIQQLSESWLKERQAYLNTISSLKDLISKMQVRRETEVYDRCHLSDWRGELLLACQRVFIKERSVLLATFQTELTSLSTRDVDGLLNSLEQRIQEQGIEYHTAMDCLQKADRRSLLAEIEDLRAQINGGKMTLEREQGTEKSSQELLDCSMQQKQSLEMQLELSSLRDRAAELQEQLSSEKMVVAELKSELAQAKLELGTTLKAQHKRLKELEAFRSEVKEKTDEIHFLSDTLAREQKNSLELQWALEKEKARSGHHEEREKEELEDLKFSLEDQKRRNTQLNLLLEQQKQLLNESQQKIESQKMLHDAQLSEEQGRNLGLQALLESEQVRIQEMKSTLDKERELYAQLQSREDGGQPPPALPSEDLLKELQKQLEEKHSRIVELLSETEKYKLDSLQTRQQMEKDRQVHQKTLQTEQEANTQGQKKMQELQSKVEELQRQLQEKRQQVYKLDLEGKRLQGLMQEFQKQELEPEEKPGSRGLVDQNLNEPATWNFTDDRTRNWVLQQKMGEAKDRNFTKLIEINGGELDHNHDLEMIRQTLQHVASKLQHVAQKACSRLQFETAGDDAFIWIQENIDGIILQLQKLTGQPGDEHSLGPPSSSCGSLTESLMRQNTELTRLINQLTEEKNTLRSIVIKLEELNRCYWHTGASRDCCSRFSFIDPADIEAIIASEKEVWNREKLSLQKALKRAEAKVYKLKAELRNDALLRNLGPDTDHAALQKIYNKYLRASSFRKALIYQKKYLLLLLGGFQECEDVTLGVLARMGGHLALKDSKTITNHPKAFSRFRSAVRVSIAISRMKFLVRRWQQVTSTSSININRDGFGLSPGIEKTDPFYHSPGGLELYGEPRHTMYRSRFDLDYPRSLLPLQNRYPGTPGDLNSISMASSQLHQYNPDKSLTDYVTRLEALRRRLGAIQSGSTTQFHFGMRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	KKQKKKRTSSSKHDS HHHCCCCCCCCCCCC	41.67	30635358
41	Phosphorylation	KQKKKRTSSSKHDSS HHCCCCCCCCCCCCC	36.33	30635358
42	Phosphorylation	QKKKRTSSSKHDSSL HCCCCCCCCCCCCCC	42.67	30635358
43	Phosphorylation	KKKRTSSSKHDSSLH CCCCCCCCCCCCCCC	33.50	30635358
47	Phosphorylation	TSSSKHDSSLHTDQQ CCCCCCCCCCCCCHH	34.22	30635358
48	Phosphorylation	SSSKHDSSLHTDQQS CCCCCCCCCCCCHHH	30.17	30635358
51	Phosphorylation	KHDSSLHTDQQSGEL CCCCCCCCCHHHCCC	40.57	30635358
55	Phosphorylation	SLHTDQQSGELCSES CCCCCHHHCCCCCCC	28.71	30635358
139	Phosphorylation	SEQGAQSSQTCLQMV CCHHHHHHHHHHHHH	19.89	-
253	Ubiquitination	ATDLLQAKRQIFTQQ HHHHHHHHHHHHHHH	31.69	-
322	Acetylation	TRVVEEEKKTVELKN HHHHHHHHHHHHHHH	57.96	23806337
323	Acetylation	RVVEEEKKTVELKNK HHHHHHHHHHHHHHH	62.17	23806337
642	Phosphorylation	KDNLGIHYKQQIDGL HHHCCCCHHHHHHHH	14.47	65501
774	Phosphorylation	EDKLKMYSPSEQEER HHHHHCCCCCHHHHH	20.60	55027549
868	Phosphorylation	QTKQALEYESKLRAL HHHHHHHHHHHHHHH	26.76	59150135
876	Phosphorylation	ESKLRALEEELLSKR HHHHHHHHHHHHHCC	48.73	24719451
893	Phosphorylation	PXAPKGKSSGIFPSE CCCCCCCCCCCCCCC	42.33	23984901
894	Phosphorylation	XAPKGKSSGIFPSET CCCCCCCCCCCCCCC	39.12	24719451
895	Phosphorylation	APKGKSSGIFPSETL CCCCCCCCCCCCCCE	32.42	24719451
899	Phosphorylation	KSSGIFPSETLEIGE CCCCCCCCCCEEECC	32.25	23984901
901	Phosphorylation	SGIFPSETLEIGEVV CCCCCCCCEEECCEE	33.75	23984901
1005	Phosphorylation	VMGKVGDSGGSISKI EEEECCCCCCCHHHH	38.84	22817900
1011	Acetylation	DSGGSISKISKDLAE CCCCCHHHHCHHHHH	49.70	19857819
1014	Acetylation	GSISKISKDLAEESK CCHHHHCHHHHHHCC	61.30	19857825
1288	Phosphorylation	SLESKVSSLPASEKN CHHHHHHCCCHHHHH	41.16	-
1307	Phosphorylation	RQVQELQSPVAAGQL HHHHHHCCHHHHCCC	33.69	63808601
1492	Phosphorylation	YRKAVPLSSHDDLDD HHHCCCCCCCCCHHH	21.40	28066266
1493	Phosphorylation	RKAVPLSSHDDLDDI HHCCCCCCCCCHHHH	38.32	26824392
1535	Phosphorylation	HDEVLVSSMDTSRQL CCCEEECCCCHHHHH	17.13	25338131
1664	Phosphorylation	EQTLKDKTLERSPED HHHHHHHCCCCCHHH	43.94	26643407
1668	Phosphorylation	KDKTLERSPEDALLD HHHCCCCCHHHHHHC	24.22	24899341
1769	Phosphorylation	TAIATHDSIWSKVTE CEEECCCCHHHHCCH	20.53	28285833
1772	Phosphorylation	ATHDSIWSKVTEEGA ECCCCHHHHCCHHHH	18.64	28285833
2024	Succinylation	ALEKQLEKMRKFLDE HHHHHHHHHHHHHHH	53.23	26388266
2136	Phosphorylation	KVEDQKRSGAVAADP CHHHCCCCCCCCCCC	37.83	-
2146	Phosphorylation	VAADPELSLEVQLQA CCCCCCCCCEEHHHH	22.33	22817900
2441	Phosphorylation	KPLEKQTSLTRLQES CCHHHCCCHHHHHCC	25.83	29514104
2448	Phosphorylation	SLTRLQESPEASRTQ CHHHHHCCCCHHHHH	18.32	26745281
2452	Phosphorylation	LQESPEASRTQEIES HHCCCCHHHHHHHHH	33.91	28066266
2454	Phosphorylation	ESPEASRTQEIESLA CCCCHHHHHHHHHHH	28.23	26643407
2459	Phosphorylation	SRTQEIESLASSVGA HHHHHHHHHHHHCCC	34.59	26745281
2463	Phosphorylation	EIESLASSVGAKDVE HHHHHHHHCCCCHHH	20.97	22006019
2501	Dimethylation	KKLTDLQRSLEKFAA HHHHHHHHHHHHHHH	50.97	-
2533	Phosphorylation	HQEKQPVSSAPGSTD CCCCCCCCCCCCCCC	27.71	25777480
2534	Phosphorylation	QEKQPVSSAPGSTDI CCCCCCCCCCCCCCC	38.42	25777480
2538	Phosphorylation	PVSSAPGSTDIQNAN CCCCCCCCCCCCCCC	23.11	25777480
2539	Phosphorylation	VSSAPGSTDIQNANG CCCCCCCCCCCCCCC	42.93	25777480
2548	Phosphorylation	IQNANGLTGASTESL CCCCCCCCCCCHHHH	31.91	25777480
2551	Phosphorylation	ANGLTGASTESLIPT CCCCCCCCHHHHCCC	33.77	25777480
2552	Phosphorylation	NGLTGASTESLIPTV CCCCCCCHHHHCCCH	29.12	25777480
2554	Phosphorylation	LTGASTESLIPTVTL CCCCCHHHHCCCHHH	31.52	25777480
2558	Phosphorylation	STESLIPTVTLRLAE CHHHHCCCHHHHHHH	21.09	25777480
2560	Phosphorylation	ESLIPTVTLRLAEVE HHHCCCHHHHHHHHH	14.51	25777480
2568	Phosphorylation	LRLAEVESRVAEVHS HHHHHHHHHHHHCCC	36.91	25777480
2618	Phosphorylation	PEEGGEQSSRDGEVR CCCCCCCCCCCHHHH	24.04	30352176
2619	Phosphorylation	EEGGEQSSRDGEVRE CCCCCCCCCCHHHHH	33.80	30352176
2652	Phosphorylation	EAKEKLSYSLEKEKR HHHHHHHHHHHHHCC	27.93	28725479
2653	Phosphorylation	AKEKLSYSLEKEKRT HHHHHHHHHHHHCCC	27.03	28725479
2665	Phosphorylation	KRTGEQESREAPIPE CCCCCCCCCCCCCCC	34.81	29514104
2675	Phosphorylation	APIPEPPSVEVGGCS CCCCCCCCEECCCCC	41.44	29514104
2754	Phosphorylation	ESRHILETESLKKEH HHCHHHCCHHHHHHH	27.68	23737553
2756	Phosphorylation	RHILETESLKKEHYV CHHHCCHHHHHHHHH	53.56	23737553
2788	Phosphorylation	CLRCKEGSSIPELAD HHHCCCCCCCHHHHH	26.62	30352176
2789	Phosphorylation	LRCKEGSSIPELADS HHCCCCCCCHHHHHH	53.68	29514104
2806	Phosphorylation	YQSREVYSSDSESDW HHCCCCCCCCCCCCC	32.61	25195567
2807	Phosphorylation	QSREVYSSDSESDWG HCCCCCCCCCCCCCH	27.71	25195567
2856	Phosphorylation	SEGMQVLSLSSPLCD CCCCEEEEECCCCCC	27.61	26745281
2858	Phosphorylation	GMQVLSLSSPLCDDG CCEEEEECCCCCCCC	26.91	26745281
2859	Phosphorylation	MQVLSLSSPLCDDGE CEEEEECCCCCCCCC	27.47	29514104
2869	Phosphorylation	CDDGEDRSIQQLSES CCCCCCCHHHHHHHH	36.75	27357545
2874	Phosphorylation	DRSIQQLSESWLKER CCHHHHHHHHHHHHH	25.83	26745281
2876	Phosphorylation	SIQQLSESWLKERQA HHHHHHHHHHHHHHH	34.04	27357545
2956	Phosphorylation	DVDGLLNSLEQRIQE CHHHHHHHHHHHHHH	33.00	28066266
2982	Phosphorylation	LQKADRRSLLAEIED HHHHHHHHHHHHHHH	28.73	29139169
3000	Phosphorylation	QINGGKMTLEREQGT HHCCCCCEEEECCCC	29.02	25367039
3007	Phosphorylation	TLEREQGTEKSSQEL EEEECCCCCHHHHHH	39.68	54886691
3010	Phosphorylation	REQGTEKSSQELLDC ECCCCCHHHHHHHHC	30.90	25521595
3011	Phosphorylation	EQGTEKSSQELLDCS CCCCCHHHHHHHHCH	38.45	25521595
3032	Phosphorylation	LEMQLELSSLRDRAA HHHHHHHHHHHHHHH	20.25	25159016
3033	Phosphorylation	EMQLELSSLRDRAAE HHHHHHHHHHHHHHH	39.80	25159016
3139	Phosphorylation	ELEDLKFSLEDQKRR HHHHHCCCHHHHHHH	29.30	23737553
3347	Phosphorylation	EPEEKPGSRGLVDQN CCCCCCCCCCCCCCC	31.53	30352176
3463	Phosphorylation	GQPGDEHSLGPPSSS CCCCCCCCCCCCCCC	32.73	22817900
3533	Phosphorylation	FSFIDPADIEAIIAS CCCCCHHHHHHHHHC	44.65	24719451
3540	Phosphorylation	DIEAIIASEKEVWNR HHHHHHHCHHHHHCH	38.50	22817900
3642	Phosphorylation	GHLALKDSKTITNHP CEEEECCCCCCCCCH	30.06	25338131
3679	Phosphorylation	VRRWQQVTSTSSINI HHHHHCCCCCCCEEE	23.19	22871156
3694	Phosphorylation	NRDGFGLSPGIEKTD CCCCCCCCCCCCCCC	22.81	25521595
3699	Ubiquitination	GLSPGIEKTDPFYHS CCCCCCCCCCCCCCC	57.20	-
3700	Phosphorylation	LSPGIEKTDPFYHSP CCCCCCCCCCCCCCC	35.79	25777480
3704	Phosphorylation	IEKTDPFYHSPGGLE CCCCCCCCCCCCCCC	13.53	25777480
3706	Phosphorylation	KTDPFYHSPGGLELY CCCCCCCCCCCCCCC	17.54	25777480
3713	Phosphorylation	SPGGLELYGEPRHTM CCCCCCCCCCCCCCC	15.29	25777480
3723	Phosphorylation	PRHTMYRSRFDLDYP CCCCCCCCCCCCCCC	21.58	22817900
3729	Phosphorylation	RSRFDLDYPRSLLPL CCCCCCCCCHHHCCC	14.08	51361
3732	Phosphorylation	FDLDYPRSLLPLQNR CCCCCCHHHCCCCCC	29.74	-
3755	Phosphorylation	NSISMASSQLHQYNP HHHHHHHHHHHHHCC	27.50	-
3787	Phosphorylation	LGAIQSGSTTQFHFG HCCCCCCCCCEEECC	33.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKAP9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKAP9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKAP9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSNAX_MOUSE	Tsnax	physical	12036294

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.