TSNAX_MOUSE - dbPTM
TSNAX_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSNAX_MOUSE
UniProt AC Q9QZE7
Protein Name Translin-associated protein X
Gene Name Tsnax
Organism Mus musculus (Mouse).
Sequence Length 290
Subcellular Localization Cytoplasm, perinuclear region. Golgi apparatus . Nucleus. Expressed in the cytoplasm in the presence of TSN (By similarity). Accumulate in the Golgi complex of mid-late pachytene spermatocytes..
Protein Description Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity)..
Protein Sequence MNGKEGPGGFRKRKHDTFPHNQRREGKDASLSSPVMLAFKSFQQELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEEILTESESKLDGVRQKILQVAQELSGEDMHQFHRAVTTGLQEYVEAVSFQHFIKTRSLISMEEINKQLTFTAEDSGKESKTPPAEGQEKQLVTWRLKLTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVFSVKTDMIDQEESIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationFRKRKHDTFPHNQRR
CCCCCCCCCCCCCCC		38.4927841257
30PhosphorylationRREGKDASLSSPVML
CCCCCCCCCCCHHHH		38.6328833060
32PhosphorylationEGKDASLSSPVMLAF
CCCCCCCCCHHHHHH		30.0525521595
33PhosphorylationGKDASLSSPVMLAFK
CCCCCCCCHHHHHHH		27.1426824392
60PhosphorylationYERLVKLSRDITVES
HHHHHHHHCCCCCCC		23.3823737553
64PhosphorylationVKLSRDITVESKRTI
HHHHCCCCCCCCCHH		23.6223737553
67PhosphorylationSRDITVESKRTIFLL
HCCCCCCCCCHHHHH		24.0923737553
68UbiquitinationRDITVESKRTIFLLH
CCCCCCCCCHHHHHE		39.8022790023
78PhosphorylationIFLLHRITSAPDMEE
HHHHEECCCCCCHHH		20.8428066266
79PhosphorylationFLLHRITSAPDMEEI
HHHEECCCCCCHHHH		35.1228066266
93UbiquitinationILTESESKLDGVRQK
HHHHCHHHHHHHHHH		46.6922790023
155PhosphorylationINKQLTFTAEDSGKE
HHHHHEEEECCCCCC		24.7326160508
159PhosphorylationLTFTAEDSGKESKTP
HEEEECCCCCCCCCC		43.1826525534
163PhosphorylationAEDSGKESKTPPAEG
ECCCCCCCCCCCCCC		45.3630352176
165PhosphorylationDSGKESKTPPAEGQE
CCCCCCCCCCCCCCC		43.7325521595
173UbiquitinationPPAEGQEKQLVTWRL
CCCCCCCCEEEEEEE		40.8327667366
237PhosphorylationFIGNTGPYEVSKKLY
CCCCCCCHHHHHHHH		30.2417203969
241UbiquitinationTGPYEVSKKLYTLKQ
CCCHHHHHHHHHHHH		52.5622790023
241AcetylationTGPYEVSKKLYTLKQ
CCCHHHHHHHHHHHH		52.5623236377
242UbiquitinationGPYEVSKKLYTLKQS
CCHHHHHHHHHHHHH		38.94-
244PhosphorylationYEVSKKLYTLKQSLA
HHHHHHHHHHHHHHH		20.93-
245PhosphorylationEVSKKLYTLKQSLAK
HHHHHHHHHHHHHHH		37.60-
249PhosphorylationKLYTLKQSLAKVENA
HHHHHHHHHHHHHHH		28.8030635358
252AcetylationTLKQSLAKVENACYA
HHHHHHHHHHHHHHH		56.2122826441
252MalonylationTLKQSLAKVENACYA
HHHHHHHHHHHHHHH		56.2126320211
258PhosphorylationAKVENACYALKVRGS
HHHHHHHHHHHCCCC		16.7430635358
288PhosphorylationDMIDQEESIS-----
CCCCCHHHCC-----		27.6430482847
290PhosphorylationIDQEESIS-------
CCCHHHCC-------		43.3730635358
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSNAX_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSNAX_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSNAX_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TSN_MOUSETsnphysical
12036294
GOGA3_MOUSEGolga3physical
12036294
TXIP1_MOUSETsnaxip1physical
12036294
SUN1_MOUSESun1physical
12036294
AKAP9_MOUSEAkap9physical
12036294
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSNAX_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-237, AND MASSSPECTROMETRY.

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