| UniProt ID | TSN_MOUSE | |
|---|---|---|
| UniProt AC | Q62348 | |
| Protein Name | Translin | |
| Gene Name | Tsn | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 228 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.; Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.. | |
| Protein Sequence | MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGTGFQDIPKRCLKAREHFSTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACGEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 56 | Ubiquitination | TGFQDIPKRCLKARE CCCCHHHHHHHHHHH | 56.95 | - | |
| 187 | Acetylation | GFRLLNLKNDSLRKR CCCHHCCCCHHHHHH | 58.60 | - | |
| 187 | Ubiquitination | GFRLLNLKNDSLRKR CCCHHCCCCHHHHHH | 58.60 | - | |
| 187 | Malonylation | GFRLLNLKNDSLRKR CCCHHCCCCHHHHHH | 58.60 | 26320211 | |
| 190 | Phosphorylation | LLNLKNDSLRKRYDG HHCCCCHHHHHHCCC | 39.19 | 29514104 | |
| 199 | Acetylation | RKRYDGLKYDVKKVE HHHCCCCCCCHHHHH | 44.96 | 23954790 | |
| 210 | Phosphorylation | KKVEEVVYDLSIRGF HHHHHHHHHHHHCCC | 19.15 | 22817900 | |
| 219 | Acetylation | LSIRGFNKETAAACG HHHCCCCHHHHHHHC | 54.93 | 22826441 | |
| 225 | Glutathionylation | NKETAAACGEK---- CHHHHHHHCCC---- | 6.57 | 24333276 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TSN_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TSN_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TSN_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TSN_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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