LRP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRP5_MOUSE
• UniProt AC: Q91VN0
• Protein Name: Low-density lipoprotein receptor-related protein 5
• Gene Name: Lrp5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1614
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Endoplasmic reticulum . Chaperoned to the plasma membrane by MESD..
• Protein Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (By similarity). Appears be required for postnatal control of vascular regression in the eye. [PubMed: 11956231 Required for posterior patterning of the epiblast during gastrulation]
• Protein Sequence: METAPTRAPPPPPPPLLLLVLYCSLVPAAASPLLLFANRRDVRLVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEQRKEILSALYSPMDIQVLSQERQPPFHTPCEEDNGGCSHLCLLSPREPFYSCACPTGVQLQDNGKTCKTGAEEVLLLARRTDLRRISLDTPDFTDIVLQVGDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIVLHPVMGLMYWTDWGENPKIECANLDGRDRHVLVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVINIDGTKRKTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADGNGGCSHLCFFTPRATKCGCPIGLELLSDMKTCIIPEAFLVFTSRATIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPDLVLPLHGLRNVKAINYDPLDKFIYWVDGRQNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGDRDKPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVEKTTGDKRTRVQGRVTHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACTTGEIDCIPGAWRCDGFPECADQSDEEGCPVCSASQFPCARGQCVDLRLRCDGEADCQDRSDEANCDAVCLPNQFRCTSGQCVLIKQQCDSFPDCADGSDELMCEINKPPSDDIPAHSSAIGPVIGIILSLFVMGGVYFVCQRVMCQRYTGASGPFPHEYVGGAPHVPLNFIAPGGSQHGPFPGIPCSKSVMSSMSLVGGRGSVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNVDVFYSSGIPATARPYRPYVIRGMAPPTTPCSTDVCDSDYSTSRWKSSKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPGTERSYCHLFPPPPSPCTDSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	N-linked_Glycosylation	AIKQTYLNQTGAAAQ HHHHHHHCCCCCCCC	27.27	-
137	N-linked_Glycosylation	RIEVANLNGTSRKVL EEEEEECCCCCCEEE	52.05	-
177	Methylation	GEAPRIERAGMDGST CCCCCCEECCCCCCC	33.79	30988041
445	N-linked_Glycosylation	RIEVTRLNGTSRKIL EEEEEEECCCCCEEE	48.70	-
498	N-linked_Glycosylation	RDRHVLVNTSLGWPN CCCEEEEECCCCCCC	21.57	-
535	Acetylation	VINIDGTKRKTLLED EEECCCCCCEEHHHH	58.38	7611915
704	N-linked_Glycosylation	TISRAFMNGSSVEHV HHHHHHHCCCCHHEE	40.52	-
773	Phosphorylation	ALDPTKGYIYWTEWG CCCCCCCEEEEEECC	7.75	25777480
775	Phosphorylation	DPTKGYIYWTEWGGK CCCCCEEEEEECCCC	9.59	25777480
777	Phosphorylation	TKGYIYWTEWGGKPR CCCEEEEEECCCCCC	12.61	25777480
877	N-linked_Glycosylation	ADKTSGRNRTLIQGH CHHCCCCCCEECCHH	44.83	-
941	Phosphorylation	DPSSRNCSPPSTFLL CCCCCCCCCCCCEEE	43.31	29233185
1608	Phosphorylation	HLFPPPPSPCTDSS- EECCCCCCCCCCCC-	38.08	26643407
1611	Phosphorylation	PPPPSPCTDSS---- CCCCCCCCCCC----	42.15	26643407
1613	Phosphorylation	PPSPCTDSS------ CCCCCCCCC------	21.57	26643407
1614	Phosphorylation	PSPCTDSS------- CCCCCCCC-------	47.23	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRP5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRP5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRP5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CADH2_MOUSE	Cdh2	physical	19075000
FZD1_MOUSE	Fzd1	genetic	15923619
FZD10_MOUSE	Fzd10	genetic	15923619
WNT7B_MOUSE	Wnt7b	genetic	16163358
AXIN1_MOUSE	Axin1	physical	11336703
MESD_MOUSE	Mesdc2	physical	12581525

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.