FZD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD1_MOUSE
• UniProt AC: O70421
• Protein Name: Frizzled-1
• Gene Name: Fzd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 642
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for Wnt proteins. [PubMed: 15923619 Activated by WNT7B]
• Protein Sequence: MAEEAAPSESRAAGRLSLELCAEALPGRREEVGHEDTASHRRPRADPRRWASGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQSGQQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
125	N-linked_Glycosylation	LCTDIAYNQTIMPNL EECCCCCCCCCCHHH	24.40	-
226	N-linked_Glycosylation	GELCVGQNTSDKGTP CCEECCCCCCCCCCC	35.30	-
398	Phosphorylation	GTKKEGCTILFMMLY CCCCCCHHHHHHHHH	31.41	26060331
405	Phosphorylation	TILFMMLYFFSMASS HHHHHHHHHHHHHHH	5.67	26060331
408	Phosphorylation	FMMLYFFSMASSIWW HHHHHHHHHHHHHHH	11.98	26060331
411	Phosphorylation	LYFFSMASSIWWVIL HHHHHHHHHHHHHHH	17.45	26060331
412	Phosphorylation	YFFSMASSIWWVILS HHHHHHHHHHHHHHH	16.82	26060331
419	Phosphorylation	SIWWVILSLTWFLAA HHHHHHHHHHHHHHC	16.78	26060331
421	Phosphorylation	WWVILSLTWFLAAGM HHHHHHHHHHHHCCC	15.70	26060331
602	Phosphorylation	FTVFMIKYLMTLIVG HHHHHHHHHHHHHHH	7.26	28978645
605	Phosphorylation	FMIKYLMTLIVGITS HHHHHHHHHHHHHHC	15.67	29899451
611	Phosphorylation	MTLIVGITSGFWIWS HHHHHHHHCCCEECC	19.50	29899451
612	Phosphorylation	TLIVGITSGFWIWSG HHHHHHHCCCEECCC	30.03	28978645
641	Phosphorylation	NSKQGETTV------ CCCCCCCCC------	21.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FZD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WNT7B_MOUSE	Wnt7b	physical	15923619

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.